The Best Resorts & Hotels with Spas in Southern Indiana from ₩116,818 in 2026

A modern glass building with a curved facade and a sign reading "The Kentucky Center".

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Our top choices for Southern Indiana hotels with a spa

A treatment room with a massage table, a desk with a computer, and a large mirror.

A luxurious bathroom with a large mirror, a bathtub, and a shower area.

A poolside area with lounge chairs and a towel with a monogram.

A golf course with a flag, a sand bunker, and a building in the background.

1. Belterra Casino Resort

Florence

Experience soothing river views and rejuvenating spa treatments at this hotel with indoor and outdoor pools.

₩179,895

₩217,978 total

includes taxes & fees

Sep 24 - Sep 25

A restaurant with round tables, chairs, chandeliers, and a bar area.

A hot tub with a pool, indoor seating area, and a view of the pool.

A large hotel with a prominent 'Caesars' sign, multiple floors, and a symmetrical facade.

A spacious lobby with a geometric chandelier, a reception desk, and a red accent wall.

2. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Elizabeth

Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.

₩81,097

₩116,818 total

includes taxes & fees

Oct 11 - Oct 12

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

An outdoor patio with black tables and chairs, surrounded by large windows and a row of arches.

A balcony with a view of a river, a bridge, and a cityscape.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

3. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville

Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.

₩218,784

₩257,420 total

includes taxes & fees

Oct 4 - Oct 5

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A modern bathroom with a shower, a sink, and a large mirror.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

4. 21c Museum Hotel Louisville

Downtown Louisville

Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness center in downtown Louisville.

₩226,648

₩273,374 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

A modern interior with a fireplace, bookshelves, and seating areas.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

5. Omni Louisville Hotel

Downtown Louisville

Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.

₩200,316

₩235,693 total

includes taxes & fees

Sep 11 - Sep 12

A rustic bar area with a wooden bar counter, stools, and a variety of bottles and glasses.

A porch with white rocking chairs and a table, a window with blinds, and a view of a green landscape.

A modern bathroom with a shower, a vanity with a sink, and a toilet. There are wooden shelves and a vase with flowers on the vanity.

A cozy room with a wooden wall, a sofa, and a dining table.

6. Pillow and Paddock B&B

La Grange

Relax in a cozy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.

₩407,547

₩449,279 total

includes taxes & fees

Sep 15 - Sep 16

A hotel lobby with a chandelier, wooden railings, a reception desk, and a large arched doorway.

An indoor swimming pool with clear water, surrounded by lounge chairs and a small seating area.

A spacious indoor area with a staircase, a vending machine, and a business center sign.

A hotel room with a bed, desk, chair, and a green accent wall.

7. Quality Inn Seymour I-65

Seymour

Revitalize your body and spirit in this tranquil hotel featuring a full-service daily spa, indoor pool, and 24-hour fitness center.

₩113,887

₩127,553 total

includes taxes & fees

Oct 10 - Oct 11

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Choose what matters most at spa hotels in Southern Indiana

Pool

Breakfast included

Hot tub

4 stars

5 stars

Top Southern Indiana Hotel Reviews

Drury Inn & Suites Evansville East

8/10 Good

"Always a reliable stay. Happy hour at check in is a total value and can absolutely replace going out for dinner if possible."

Big Splash Adventure Indoor Water Park & Resort

10/10 Excellent

"Todo muy bello, pasamos el cumpleaños de nuestro bebé muy bien lugar muy acogedor"

Hampton Inn New Albany Louisville West

10/10 Excellent

"Great location, nice area"

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Book Resorts & Hotels with Spas in Southern Indiana on Expedia.com

Find Resorts & Hotels with Spas in Southern Indiana

Change your mind

Treat yourself

Be picky

Check availability on Southern Indiana Resorts & Hotels with Spas

Our top choices for Southern Indiana hotels with a spa

1. Belterra Casino Resort

2. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

3. Galt House Hotel Trademark Collection by Wyndham

4. 21c Museum Hotel Louisville

5. Omni Louisville Hotel

6. Pillow and Paddock B&B

7. Quality Inn Seymour I-65

Choose what matters most at spa hotels in Southern Indiana

Top Southern Indiana Hotel Reviews

Drury Inn & Suites Evansville East

Big Splash Adventure Indoor Water Park & Resort

Hampton Inn New Albany Louisville West

Explore a world of travel with Expedia