Photo by JG Morris

Plan, book, travel with confidence
Better together
Save up to ₩234,741 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Adventure Southeast Missouri Hotels

Hampton Inn Farmington

850 Valley Creek Dr Farmington MO

2 hours drive from Mark Twain National Forest

Stay at this hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.8/10 Excellent! (539 reviews)

Just ok. Trouble getting in internet

Reviewed on Mar 26, 2026

Crown Pointe Lodge, BW Signature Collection

4245 Hunt Rd Farmington MO

2 hours drive from Mark Twain National Forest

Book a stay at this golf hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...

9/10 Wonderful! (600 reviews)

Overall it was okay, we’ve stayed here for years but it has changed owners and with that different management. Staff takes all the upfront parking including the manager. Parking in the handicap striped space that’s suppose to allow cars with handicap tags the ability to open their doors fully or ...

Reviewed on Mar 25, 2026

Echo Bluff State Park

34489 Echo Bluff Dr Eminence MO

43 min drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Eminence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Echo Bluff State Park and ...

9.6/10 Exceptional! (234 reviews)

The lodge was beautiful! Our room was good for our time there. We enjoyed being able to eat at the grille and relax for the weekend!

Reviewed on Mar 22, 2026

See all 630 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.