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Top Adventure Southeast Missouri Hotels

Hampton Inn Farmington

850 Valley Creek Dr Farmington MO

2 hours drive from Mark Twain National Forest

Stay at this hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.8/10 Excellent! (518 reviews)

Staff was amazing, super clean

Reviewed on Nov 26, 2025

Crown Pointe Lodge, BW Signature Collection

4245 Hunt Rd Farmington MO

2 hours drive from Mark Twain National Forest

Book a stay at this golf hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (575 reviews)

Clean, friendly staff enjoyed the stay

Reviewed on Dec 3, 2025

Echo Bluff State Park

34489 Echo Bluff Dr Eminence MO

43 min drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Eminence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Echo Bluff State Park and ...

9.4/10 Exceptional! (217 reviews)

The property was nice and our stay was good. Off season and only one other couple there so we had the run of the place. Staff was great and helpful with local information. Things to improve on would be the noisy HVAC system, A light over the coffee station would be helpful as the only lights were ...

Reviewed on Dec 14, 2025

See all 620 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.