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Top Honeymoon Southeast Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business center, and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (498 reviews)

n/a - the rooms do not have kitchens. The main kitchen is used by the owner to prepare breakfast.

Reviewed on Apr 13, 2026

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.4/10 Very Good! (206 reviews)

Great breakfast, friendly staff, subway level to Mayo was so helpful

Reviewed on Mar 19, 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Book a stay at this spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,005 reviews)

This was such a beautiful step back in history with luxury and romance. The beds were pillow top but not memory foam, which we appreciated. The little amenities of bath robes, kuerig machine, extremely soft sheets and even a make-up washcloth (not just wipes like other hotels) were wonderful! The ...

Reviewed on Apr 28, 2026

See all 945 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.