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Top Honeymoon Southeast Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business center, and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (493 reviews)

Great history, great service, worth more than what was paid.

Reviewed on Mar 8, 2026

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions ...

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Book a stay at this spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,002 reviews)

Absolutely beautiful! Our suite was huge and beautiful! Staff was friendly and superbly efficient. Location could not have been better for our stay. We will definitely be back!

Reviewed on Mar 6, 2026

See all 939 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.