Upstate South Carolina Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
Photo by South Carolina Department of Parks, Recreation & Tourism
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Save up to ₩234,741 when you book a flight and hotel together*
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Top Luxury Upstate South Carolina Hotels
The Westin Poinsett Greenville
120 South Main St, Greenville, SC
Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...
9.2/10 Wonderful! (1,000 reviews)
"Amazing. The staff was very attentive to our needs."
Reviewed on Jul 1, 2025
Hyatt Regency Greenville
220 N Main St, Greenville, SC
Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...
8.6/10 Excellent! (1,000 reviews)
"Great location."
Reviewed on Jun 29, 2025
Sleep Inn at Greenville Convention Cente
231 N Pleasantburg Dr, Greenville, SC
Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.
7.8/10 Good! (984 reviews)
"👍"
Reviewed on Jun 20, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.