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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...

9.2/10 Wonderful! (1,004 reviews)

"Wonderful room, view, amenities and customer service"

Reviewed on May 23, 2026

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...

8.8/10 Excellent! (1,008 reviews)

"The hotel is looking its age in the hallways and stairwells. Carpets stained and water damaged on our floor. The common areas on each floor level smelled bad and musty. The gave us an accessible room which didn’t suit us and the attached parking lot was full and we had to use valet parking at $33 ..."

Reviewed on May 25, 2026

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.

8/10 Very Good! (1,002 reviews)

"Older building and worn rooms"

Reviewed on May 20, 2026

See all 2,997 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.