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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...

9.2/10 Wonderful! (1,001 reviews)

Valet parking was much easier but significantly more expensive.

Reviewed on Mar 20, 2026

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...

8.8/10 Excellent! (1,002 reviews)

Check in was easy. Front desk staff was very friendly.

Reviewed on Mar 24, 2026

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.

8/10 Very Good! (1,000 reviews)

Room was clean although furniture was beat up. Outside of building had damage to a/c vents and trim; some windows were cloudy indicating they'd lost their seal. Breakfast experience was poor. Juice machine had off-flavored juice. Waffle mix was separated or not mixed properly. No brewed coffee, only ...

Reviewed on Mar 26, 2026

See all 2,955 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.