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Top Luxury Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...

8.2/10 Very Good! (1,828 reviews)

Room was clean, rooftop, pool, and sauna was a great spot to relax. The convenience of walking around underground in the winter to get to stores and restaurants is genius! Check out at noon too! Only issue was we have a large truck

Reviewed on Dec 11, 2025

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...

7.8/10 Good! (1,005 reviews)

A little out of date and outside lights were all working. But it was just we needed for a stay at Mayo so I was happy with the kitchenette and the lower nightly rate. They also let me cancel a night when we got discharged early

Reviewed on Dec 13, 2025

AmericInn by Wyndham Northfield

1320 Bollenbacher Dr Northfield MN

2 hours drive from Mayo Clinic

AmericInn by Wyndham Northfield offers a luxury stay. Popular amenities include an indoor pool and a hot tub.

8.2/10 Very Good! (621 reviews)

Staff was courteous.

Reviewed on Dec 6, 2025

See all 934 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.