Photo by RVLuckyorWhat

Plan, book, travel with confidence
Better together
Save up to ₩234,741 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Pet-friendly Upstate South Carolina Hotels

Aloft Greenville Downtown

5 North Laurens Street Greenville SC

1 hour drive from Clemson University

Dogs and cats are welcome (fees apply) at this city-center hotel offering pet-friendly amenities, like food and water bowls. While you're here, take a stroll ...

9/10 Wonderful! (1,001 reviews)

It is a really great location and we enjoyed our room.

Reviewed on Feb 7, 2026

La Quinta Inn & Suites by Wyndham Greenville Haywood

65 W Orchard Park Dr Greenville SC

1 hour drive from Clemson University

This pet-friendly hotel welcomes dogs and cats (fees apply).

7.2/10 Good! (1,122 reviews)

The Staff is Mostly friendly. The Room was Very Clean upon arrival. Breakfast is pretty good. Very Quiet here. Great views from the 7th floor

Reviewed on Jan 28, 2026

Best Western Greenville Airport Inn

5009 Pelham Road Greenville SC

2 hours drive from Clemson University

Dogs and cats will approve of the pet-friendly amenities, such as a dog park, during their stay at this hotel (fees apply for pets).

7.6/10 Good! (1,004 reviews)

The girl at the front desk was excellent eith information.

Reviewed on Feb 5, 2026

See all 2,945 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.