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Top Pet-friendly Southern Minnesota Hotels

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

4353 Canal Pl SE Rochester MN

11 min drive from Mayo Clinic

Make it a pet-friendly trip and bring along your four-legged friend. Dogs are welcome (fees apply) at this suburban hotel.

7.2/10 Good! (1,040 reviews)

NICE

Reviewed on Feb 17, 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Dogs are welcome to join you (fees apply) for a pet-friendly getaway at this family-friendly, city-center motel.

7.8/10 Good! (1,007 reviews)

Great staff. Room was great and on the first floor as requested. It was also connected to Famous Dave’s restaurant to eat at. Pool was a good way to recover from a long trip in the car.

Reviewed on Feb 20, 2026

Spark by Hilton Rochester South

4165 Maine Ave SE Rochester MN

10 min drive from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

9.4/10 Exceptional! (379 reviews)

Staff were very friendly, entire space was exceptionally clean, and the pool and the hot tub were some of the best maintained that I have seen. 10-10 experience.

Reviewed on Feb 22, 2026

See all 1,208 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.