Florida Keys Spa Vacations

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    Save up to ₩1,660,000 when you book a flight and hotel together*
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Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

Cheeca Lodge & Spa

5 out of 5
81801 Overseas Highway, Mile Marker 82 Islamorada FL
  • 3 hours drive from Florida Keys Beaches
Book a stay at this luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff ...
9.2/10 Wonderful! (1,329 reviews)

Travelers like: full-service spa, sauna, steam room, massage

Travelers say...
"The decor was updated a bit but then dated in other areas. The balcony cushions had stains and the carpet needed to be replaced."

Reviewed on Jun 23, 2026

Cheeca Lodge & Spa
Pier House Resort & Spa

Pier House Resort & Spa

4 out of 5
1 Duval St Key West FL
  • 37 min drive from Florida Keys Beaches
Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
9/10 Wonderful! (1,187 reviews)

Travelers like: full-service spa, massage, facials, manicures and pedicures

Travelers say...
"Not all the rooms that say have a roll in shower actually do. The swimming pool wheelchair lift does not work. The rooms that have roll in showers are nice but not Junior Suites."

Reviewed on Jun 24, 2026

Pier House Resort & Spa
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
  • 36 min drive from Florida Keys Beaches
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,402 reviews)

Travelers like: full-service spa, massage, facials, couples spa treatments

Travelers say...
"The room was very clean. The staff was helpful."

Reviewed on Jun 24, 2026

Southernmost Beach Resort and Guesthouses
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.