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Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

3 hours drive from Florida Keys Beaches

Book a stay at this luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff ...

9.2/10 Wonderful! (1,329 reviews)

Travelers like: full-service spa, sauna, steam room, massage

Travelers say...

"The decor was updated a bit but then dated in other areas. The balcony cushions had stains and the carpet needed to be replaced."

Reviewed on Jun 23, 2026

Pier House Resort & Spa

1 Duval St Key West FL

37 min drive from Florida Keys Beaches

Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...

9/10 Wonderful! (1,187 reviews)

Travelers like: full-service spa, massage, facials, manicures and pedicures

Travelers say...

"Not all the rooms that say have a roll in shower actually do. The swimming pool wheelchair lift does not work. The rooms that have roll in showers are nice but not Junior Suites."

Reviewed on Jun 24, 2026

Southernmost Beach Resort and Guesthouses

1319 Duval Street Key West FL

36 min drive from Florida Keys Beaches

Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...

8.8/10 Excellent! (3,402 reviews)

Travelers like: full-service spa, massage, facials, couples spa treatments

Travelers say...

"The room was very clean. The staff was helpful."

Reviewed on Jun 24, 2026

See all 8,301 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.