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Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

3 hours drive from Duval Street

Book a stay at this luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff ...

9.2/10 Wonderful! (1,327 reviews)

Travelers like: full-service spa, sauna, steam room, massage

Travelers say...

Beautiful!!!

Reviewed on May 7, 2026

Pier House Resort & Spa

1 Duval St Key West FL

11 min walk from Duval Street

Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...

9/10 Wonderful! (1,111 reviews)

Travelers like: full-service spa, massage, facials, manicures and pedicures

Travelers say...

The staff can't do anything about the seaweed onslaught, however they could have done a better job on clearing the small beach area of the nasty stuff. The one attendant there working on it could have used some help. Another let down was that we were on a second floor with no elevator. It would have ...

Reviewed on May 9, 2026

Southernmost Beach Resort and Guesthouses

1319 Duval Street Key West FL

10 min walk from Duval Street

Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...

8.8/10 Excellent! (3,290 reviews)

Travelers like: full-service spa, massage, facials, couples spa treatments

Travelers say...

Check in was a long line. Front desk gave me wrong information

Reviewed on May 7, 2026

See all 8,336 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.