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Top Cheap Southeast Missouri Hotels

Super 8 by Wyndham Farmington

930 Valley Creek Dr Farmington MO

2 hours drive from Mark Twain National Forest

Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

8/10 Very Good! (612 reviews)

The room was excellent and the staff was extremely nice

Reviewed on Nov 25, 2025

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...

7.8/10 Good! (1,000 reviews)

Staff was amazing and super nice. Room was very clean.

Reviewed on Dec 11, 2025

Pear Tree Inn Sikeston

2602 E Malone Avenue Sikeston MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...

9.2/10 Wonderful! (1,000 reviews)

This is our go to when we visit relatives

Reviewed on Dec 5, 2025

See all 620 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.