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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...

9.4/10 Exceptional! (1,001 reviews)

"Great location. Very friendly staff."

Reviewed on Jul 2, 2026

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...

8.8/10 Excellent! (1,001 reviews)

"Great hotel overall. The night we stayed they were booked to capacity and our AC wasn’t working below 75. After being in the heat for a concert, it was really inconvenient."

Reviewed on Jun 30, 2026

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.

8/10 Very Good! (1,001 reviews)

"Parking - not enough Room - clean but needs updating and there were drawings on the wall Did not get up in time for the breakfast. Did like that it was quiet."

Reviewed on Jun 29, 2026

See all 3,024 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.