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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...

9.2/10 Wonderful! (1,001 reviews)

Very accomodating; catered to our needs and requests

Reviewed on Feb 1, 2026

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...

8.6/10 Excellent! (1,001 reviews)

The staff was great to us during the ice storm! Lots of places to hang out.

Reviewed on Jan 28, 2026

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.

7.8/10 Good! (1,003 reviews)

It was good just needed to update and remodel rooms

Reviewed on Feb 3, 2026

See all 2,945 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.