Photo by Nikki Benson

Plan, book, travel with confidence
Better together
Save up to ₩234,741 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Eastern Piedmont Hotels

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Pamper yourself with an extravagant stay at The Umstead Hotel and Spa, where you'll find deep soaking bathtubs and pillowtop beds. The spa, outdoor pool, and ...

9.6/10 Exceptional! (742 reviews)

Wonderful for a luxury spa getaway

Reviewed on Mar 14, 2026

The Carolina Inn, a Destination by Hyatt Hotel

211 Pittsboro Street Chapel Hill NC

16 min drive from Duke University

Go for a luxurious stay at The Carolina Inn, a Destination by Hyatt Hotel, where you can enjoy amenities like pillowtop beds, premium channels, and more. Notable ...

9.6/10 Exceptional! (1,000 reviews)

Wonderful place to stay while visiting UNC. The food at the restaurant was delicious. We enjoyed our stay very much.

Reviewed on Mar 14, 2026

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

The Mayton is one of the Cary luxury 4-star boutique properties where you can pamper yourself with Champagne service, pillowtop beds, and more. Notable amenities ...

9.4/10 Exceptional! (737 reviews)

Wonderful place walking distance to everything downtown, only complaint is no parking, you have to find a spot on street or around corner in a parking garage which may not work for everybody, we managed it fine.

Reviewed on Mar 17, 2026

See all 4,822 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.