Central Mississippi Luxury Vacations

Book a Luxury Hotel + Flight or Car together to unlock savings

Photo by Lancaster
  • Plan, book, travel with confidence

  • Better together

    Save up to ₩234,741 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Top Luxury Central Mississippi Hotels

Microtel Inn & Suites by Wyndham Meridian

Microtel Inn & Suites by Wyndham Meridian

2 out of 5
518 Bonita Lakes Dr Meridian MS
  • 3 hours drive from Mississippi State University
Microtel Inn & Suites by Wyndham Meridian provides luxe lodging where you'll enjoy premium channels and more.
6.2/10 (1,003 reviews)
Room was clean and tidy

Reviewed on Dec 29, 2025

Microtel Inn & Suites by Wyndham Meridian
Red Roof Inn Meridian

Red Roof Inn Meridian

2 out of 5
2219 S Frontage Rd Meridian MS
  • 3 hours drive from Mississippi State University
Treat yourself to some luxurious accommodations at Red Roof Inn Meridian, where you can enjoy amenities like premium channels, flat-screen TVs, and more.
6.4/10 (935 reviews)
Room is old and needs remodeling but was clean and acceptable to sleep in.

Reviewed on Dec 29, 2025

Red Roof Inn Meridian
Comfort Inn & Suites Columbus North

Comfort Inn & Suites Columbus North

2.5 out of 5
129 Brickerton St Columbus MS
  • 32 min drive from Mississippi State University
Discover luxurious lodging at Comfort Inn & Suites Columbus North, where you can enjoy amenities like plush bedding, premium channels, and more. Deluxe amenities ...
7.2/10 Good! (817 reviews)
Staff very nice, rooms and hotel clean, hot water. Breakfast decent (standard breakfast). The ONLY thing I could say is negative is that the indoor swimming pool was out of order. It wasn’t a deal breaker or anything like that BUT I think if the pool is not in working order that should be disclosed. ...

Reviewed on Jan 3, 2026

Comfort Inn & Suites Columbus North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.