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Top Luxury Panhandle Plains Hotels

Studio 6 Amarillo, TX – West Medical Center

6801 W Interstate 40, Amarillo, TX

4 hours drive from Texas Tech University

Treat yourself to some luxurious accommodations at Studio 6 Amarillo, TX – West Medical Center, where you can enjoy amenities like pillowtop beds, designer toiletries, ...

7.4/10 Good! (1,010 reviews)

"Clean room, friendly environment!"

Reviewed on Oct 11, 2025

Spark by Hilton Amarillo East

2301 East I40, Amarillo, TX

4 hours drive from Texas Tech University

Indulge yourself with classy lodging with a stay at Spark by Hilton Amarillo East, where you'll enjoy amenities like premium bedding and more. Notable amenities ...

8.8/10 Excellent! (162 reviews)

Great hotel

"The hotel was very nice, very clean. The staff was very welcoming and friendly as well, at least upon check-in. No issues with our stay, we will definitely stay again if we are ever in the area."

Reviewed on Oct 11, 2025

Hawthorn Suites by Wyndham Lubbock

4435 Marsha Sharp Fwy, Lubbock, TX

25 min walk from Texas Tech University

Hawthorn Suites by Wyndham Lubbock provides luxe lodging where you'll enjoy pillowtop beds and more. The indoor pool, fitness center, and hot tub are just some ...

7.8/10 Good! (1,005 reviews)

"Clean room Just needed to have more lighted soace for parking…will definitely book here again"

Reviewed on Oct 10, 2025

See all 2,161 properties in Panhandle Plains

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.