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Top Luxury Northeast Missouri Hotels

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

6 min drive from St. Louis Union Station

Treat yourself to some luxurious accommodations at The Royal Sonesta Chase Park Plaza St. Louis, where you can enjoy amenities like pillowtop beds, designer ...

9/10 Wonderful! (1,011 reviews)

"Loved our stay! We had a girls’ weekend and the pool was definitely the highlight of our stay with the good drinks and food!"

Reviewed on Jun 29, 2026

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

34 min drive from St. Louis Union Station

Stay in the lap of luxury at Ameristar Casino Resort and Spa, where you can enjoy amenities like plush bedding, HDTVs, and more. Notable amenities include a ...

8.6/10 Excellent! (1,006 reviews)

"Nice room! Double sinks came in handy. Loved the step down sitting room . Plenty of parking. Areas from garage to inside, could have been cleaner. Microwave for guests would have been nice. Overall, enjoyed the stay."

Reviewed on Jun 28, 2026

The Ritz-Carlton, St. Louis

100 Carondelet Plaza St. Louis MO

13 min drive from St. Louis Union Station

Be treated to a luxury stay at The Ritz-Carlton, St. Louis, where you can enjoy amenities like plush bedding, designer toiletries, and more. The 3 bars, fitness ...

9.2/10 Wonderful! (573 reviews)

"Very nice property to stay at and a nice walk to Shaw Park."

Reviewed on Jun 28, 2026

See all 2,953 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.