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Top Luxury Northeast Missouri Hotels

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

6 min drive from St. Louis Union Station

Treat yourself to some luxurious accommodations at The Royal Sonesta Chase Park Plaza St. Louis, where you can enjoy amenities like pillowtop beds, designer ...

9/10 Wonderful! (1,013 reviews)

The room was amazing and the staff made our stay perfect! There is so much to do at the hotel from the movie theatre to dining and drinks you really don’t have to leave.

Reviewed on Jan 23, 2026

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

34 min drive from St. Louis Union Station

Stay in the lap of luxury at Ameristar Casino Resort and Spa, where you can enjoy amenities like plush bedding, HDTVs, and more. Notable amenities include a ...

8.4/10 Very Good! (1,003 reviews)

Excellent staff

Reviewed on Jan 23, 2026

The Ritz-Carlton, St. Louis

100 Carondelet Plaza St. Louis MO

13 min drive from St. Louis Union Station

Be treated to a luxury stay at The Ritz-Carlton, St. Louis, where you can enjoy amenities like plush bedding, designer toiletries, and more. The 3 bars, fitness ...

9.2/10 Wonderful! (556 reviews)

Very courteo

Reviewed on Jan 13, 2026

See all 2,823 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.