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Top Luxury Southern Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...

8.4/10 Very Good! (2,162 reviews)

"The Kahler is always an excellent choice…particularly if you are visiting the Mayo Clinic."

Reviewed on Jun 22, 2026

AmericInn by Wyndham Blue Earth

1495 Domes Dr Blue Earth MN

5 hours drive from Mayo Clinic

Go for a luxurious stay at AmericInn by Wyndham Blue Earth, where you can enjoy amenities like 24-hour room service, premium channels, and more. Deluxe amenities ...

7.8/10 Good! (493 reviews)

"Website says there is a hot tub and there is not! They were doing painting at the time of our stay so understandable things were moved around. Staff not very helpful or friendly esp when we asked why it was listed hot tub and there wasn’t one!"

Reviewed on Jun 22, 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...

8/10 Very Good! (1,004 reviews)

"Once hot breakfast was added it was a great improvement. The dining area is keep clean & isn’t crowded. Staff at front desk varied from nice to snarky. My Doctor cancelled my surgery for medical reasons & ordered me back in 2 weeks. No refunds or credits at given or allowed. Think carefully about ..."

Reviewed on Jun 22, 2026

See all 1,188 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.