Southern Minnesota Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ₩1,660,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top Luxury Southern Minnesota Hotels
Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
- 2 min walk from Mayo Clinic
Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...
AmericInn by Wyndham Blue Earth
1495 Domes Dr Blue Earth MN
- 5 hours drive from Mayo Clinic
Go for a luxurious stay at AmericInn by Wyndham Blue Earth, where you can enjoy amenities like 24-hour room service, premium channels, and more.
7.8/10 Good! (516 reviews)
"Our room smelled musty. There was no elevator. We both got some kind of bug bites. It was not clean"
Reviewed on Sep 21, 2026
Med City Inn & Suites - Mayo Clinic Area
435 16th Ave Nw Rochester MN
- 26 min walk from Mayo Clinic
Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...
7.8/10 Good! (1,020 reviews)
"Checked in to 2 rooms, one room the lock was not working properly. Tried to tell the front desk and they just gave us different key cards. Tried to tell them it was the lock itself but they just were not getting it! Finally after 3 tries they gave a different room. That room the TV wasn't working. ..."
Reviewed on Sep 25, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
