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Top Luxury Central Iowa Hotels

Des Lux Hotel

800 Locust St Des Moines IA

1 hour drive from Iowa State University

Treat yourself to a luxury stay at Des Lux Hotel, where you can enjoy amenities like designer toiletries, flat-screen TVs, and more. Notable amenities include ...

9.8/10 Exceptional! (1,052 reviews)

Friendly staff, good location and within walking distance to several restaurants.

Reviewed on May 2, 2026

Sonesta Essential Des Moines

4755 Merle Hay Road Des Moines IA

1 hour drive from Iowa State University

Indulge yourself with upscale accommodations at Sonesta Essential Des Moines, where you'll enjoy amenities like premium channels and more.

7.4/10 Good! (1,003 reviews)

Staff were great- room was clean. Bed was comfy.

Reviewed on Apr 30, 2026

La Quinta Inn & Suites by Wyndham Des Moines West Clive

1390 Nw 118th St Clive IA

1 hour drive from Iowa State University

Treat yourself to a luxury stay at La Quinta Inn & Suites by Wyndham Des Moines West Clive, where you can enjoy amenities like plush bedding, HDTVs, and ...

8.8/10 Excellent! (1,002 reviews)

I really liked the Dove hair care products, breakfast was very good and the room was spacious & clean.

Reviewed on Apr 30, 2026

See all 1,615 properties in Central Iowa

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.