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Top Romantic Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic bed & breakfast, featuring a garden and a terrace for couples to enjoy.

10/10 Exceptional! (363 reviews)

Richard was amazing. The house was beautiful and the breakfast will leave you full for hours! If you need more than one bed, take the room with the kitchenette. Its cozy and has a private entrance.

Reviewed on Nov 10, 2025

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

If you and your special someone are ready for a getaway, you're sure to love the spa and garden at this historic hotel. You'll also appreciate the luxury bedding, ...

9.2/10 Wonderful! (1,007 reviews)

Couples like: full-service spa, bar

Travelers say...

Room was clean and roomy.

Reviewed on Nov 23, 2025

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic hotel, featuring a hot tub and a lobby fireplace for couples to enjoy.

8.8/10 Excellent! (713 reviews)

The room was nice and updated

Reviewed on Nov 19, 2025

See all 1,190 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.