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Top Romantic Southeast Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic bed & breakfast, featuring a garden and a terrace for couples to enjoy.

10/10 Exceptional! (364 reviews)

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Reviewed on Dec 8, 2025

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

If you and your special someone are ready for a getaway, you're sure to love the spa and garden at this historic hotel. You'll also appreciate the luxury bedding, ...

9.2/10 Wonderful! (1,002 reviews)

Couples like: full-service spa, bar

Travelers say...

Lovely room, great restaurant on site, free parking, nice staff.

Reviewed on Dec 7, 2025

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic hotel, featuring a hot tub and a lobby fireplace for couples to enjoy.

8.8/10 Excellent! (717 reviews)

Friendly staff, clean room. Definitely would recommend.

Reviewed on Dec 15, 2025

See all 934 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.