Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Marker 82, Islamorada, FL

3 hours drive from Duval Street

Stay at this 5-star luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff ...

9/10 Wonderful! (1,149 reviews)

Travelers like: full-service spa, sauna, steam room, massage

Travelers say...

"Great place. Best way to relax and enjoy the keys."

Reviewed on Aug 17, 2025

Pier House Resort & Spa

1 Duval St, Key West, FL

11 min walk from Duval Street

Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach, and 2 bars/lounges. Our guests praise the pool and the bar in our reviews. ...

9/10 Wonderful! (1,005 reviews)

Travelers like: full-service spa, massage, facials, manicures and pedicures

Perfect Hotel for a getaway.

"We stayed at the pier house on the “off” season and just loved it. It was super cute, super clean rooms and grounds. The A/C was cold as was the fridge in our room. if I had to find something to complain about it would have to be the lighting in the bathroom was not the best- hard to do makeup in ..."

Reviewed on Aug 14, 2025

Southernmost Beach Resort and Guesthouses

1319 Duval Street, Key West, FL

11 min walk from Duval Street

Stay at this 4-star beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the bar in our reviews. ...

8.6/10 Excellent! (2,670 reviews)

Travelers like: full-service spa, massage, facials, couples spa treatments

Travelers say...

"Beautiful large resort! Loved all the pools and dining options. Try the fish tacos!!"

Reviewed on Aug 14, 2025

See all 8,285 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.