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Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

3 hours drive from Florida Keys Beaches

Book a stay at this luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff ...

Pier House Resort & Spa

1 Duval St Key West FL

37 min drive from Florida Keys Beaches

Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...

9/10 Wonderful! (1,244 reviews)

Travelers like: full-service spa, massage, facials, manicures and pedicures

Travelers say...

"5Star"

Reviewed on Jul 23, 2026

Southernmost Beach Resort and Guesthouses

1319 Duval Street Key West FL

36 min drive from Florida Keys Beaches

Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...

8.8/10 Excellent! (3,464 reviews)

Travelers like: full-service spa, massage, facials, couples spa treatments

Travelers say...

"Our room was very clean and all the staff was very friendly and helpful. We enjoyed our stay very much and will definitely go back!"

Reviewed on Jul 23, 2026

See all 8,262 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.