Find hotels near Mayo Clinic Florida, Jacksonville from ₩171,809

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 29 - Dec 30
Tomorrow
Dec 30 - Dec 31
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Mayo Clinic Florida hotels

Reception
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (447)
"Great facility to stay."
United States
Gary
The price is ₩243,641
₩276,532 total
includes taxes & fees
Dec 30 - Dec 31
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Lobby
Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
0.8 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (84)
"Great place to stay"
United States
Judy
The price is ₩204,716
₩232,352 total
includes taxes & fees
Dec 30 - Dec 31
Hilton Jacksonville At Mayo Clinic
Terrace/patio
TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (553)
"Very good hotel"
United States
Careli
The price is ₩164,349
₩186,536 total
includes taxes & fees
Jan 7 - Jan 8, 2026
TownePlace Suites by Marriott Jacksonville East
Terrace/patio
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1005)
"The room was super clean and the staff was excellent!"
United States
Angela
The price is ₩158,410
₩179,794 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
2.7 km from Mayo Clinic Florida
8.6 out of 10, Excellent, (1003)
"Good location for a family vacation "
United States
Angel
The price is ₩151,374
₩171,809 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Terrace/patio
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
0.3 km from Mayo Clinic Florida
8.4 out of 10, Very Good, (756)
"Great location "
United States
Josiah Christine
The price is ₩232,107
₩263,441 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
BBQ/picnic area
Salt Air Inn & Suites

Salt Air Inn & Suites

Salt Air Inn & Suites
2.5 star property
7.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (415)
"Great stay , convenient locations , friendly staff and well priced "
United States
Grant
Salt Air Inn & Suites
Exterior
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
Southside, 7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1005)
"Great hotel"
United States
Nima
The price is ₩188,857
₩214,353 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Property amenity
TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
3.0 star property
10.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (67)
"This was an awesome place to stay."
United States
Christine
The price is ₩167,233
₩189,809 total
includes taxes & fees
Jan 4 - Jan 5, 2026
TownePlace Suites by Marriott® Jacksonville Mayport
Exterior
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
4.2 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1006)
"Good location for exploring Ponte Vedra and Jacksonville Beach areas."
United States
Julianne
The price is ₩175,839
₩199,578 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Standard Room, 2 Queen Beds, Non Smoking | Down comforters, minibar, iron/ironing board, WiFi
The Hotel Palms

The Hotel Palms

The Hotel Palms
3.5 star property
7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (291)
"stayed here for an event and it was awesome"
United States
clayton
The price is ₩243,641
₩276,540 total
includes taxes & fees
Jan 1 - Jan 2, 2026
The Hotel Palms
On the beach, white sand, surfing, kayaking
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
5.9 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (3443)
"Nice stay!"
United States
Mark
The price is ₩193,326
₩219,426 total
includes taxes & fees
Dec 30 - Dec 31
Margaritaville Jacksonville Beach
Reception
Ponte Vedra Inn & Club

Ponte Vedra Inn & Club

Ponte Vedra Inn & Club
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (813)
"Wonderful place to visit to relax. Very clean, very friendly and courteous staff. Great view from the balcony."
United States
Greg
The price is ₩575,222
₩683,181 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Ponte Vedra Inn & Club
Beach/ocean view
The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (688)
"Clean room, excellent service and only steps from the ocean. The facility could use some TLC but, all in all, a wonderful place to stay. We’ll be back for sure. "
United States
Robert
The price is ₩575,222
₩683,181 total
includes taxes & fees
Jan 3 - Jan 4, 2026
The Lodge and Club at Ponte Vedra Beach
On the beach
Best Western Oceanfront

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
5.7 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1007)
"Great location, clean, comfortable bed, friendly staff"
United States
Jeff
The price is ₩177,598
₩201,573 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Best Western Oceanfront
On the beach, windsurfing
Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
5.8 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (623)
"The room was great and the staff was exceptional. Would stay here again in a heartbeat. "
United States
Michael
The price is ₩237,874
₩269,988 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Exterior
Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
5.6 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1000)
"Easy to walk to the beach and local restaurant"
United States
Allen D
The price is ₩256,615
₩291,257 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Four Points by Sheraton Jacksonville Beachfront
Free daily buffet breakfast
Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
4.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1001)
"Staff is terrific and the room was very clean and comfortable."
United States
Gerri
The price is ₩165,791
₩188,172 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Holiday Inn Express Jacksonville Beach by IHG
Sports facility
Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
Southside, 8.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1005)
"Breakfast was great. The selection was the best I have ever had in the US"
United States
Sandra
The price is ₩183,091
₩207,808 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Hyatt Place Jacksonville / St. Johns Town Center
2 outdoor pools, open 7:00 AM to 9:00 PM, pool umbrellas, sun loungers
Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
3.0 star property
6.3 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (2617)
"The room was clean, staff was friendly and we loved the location. "
United States
Diane
The price is ₩189,146
₩214,680 total
includes taxes & fees
Jan 22 - Jan 23, 2026
Hampton Inn Jacksonville Beach/Oceanfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mayo Clinic Florida Hotel Reviews

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

10/10 Excellent
"Most everything"
Robert 4-night trip
Posted 21 hours ago
Hilton Jacksonville At Mayo Clinic

Hotels near other Mayo Clinic Florida attractions

Adventure Landing

4.1/5 (157 reviews)
This amusement park east of Jacksonville is a fun daytrip for the whole family with thrilling rides, exciting attractions for kids and a shipwreck-themed waterpark.
See properties

Windsor Parke Golf Club

Enjoy a round of golf in Jacksonville at Windsor Parke Golf Club. Amble around the area's beautiful beaches or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 43 hotels and other accommodations you'll find within a mile.
What's the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville At Mayo Clinic and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels will I find near Mayo Clinic Florida?
Expedia has 43 hotels and other accommodations within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.
Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?
To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.
What can I see and do near Mayo Clinic Florida?
You can enjoy live performances at Players by the Sea and Wilson Center For the Arts. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.