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Dec 12 - Dec 13
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Dec 13 - Dec 14
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Dec 12 - Dec 14
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Dec 19 - Dec 21

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Our top choices for Medical Center Area hotels

Exterior detail
The Inn at Longwood Medical

The Inn at Longwood Medical

The Inn at Longwood Medical
3.5 star property
Medical Center Area
8.4 out of 10, Very Good, (1004)
"Nice hotel in a good location. "
United States
Chrisann
The price is ₩297,664
₩389,283 total
includes taxes & fees
Jan 1 - Jan 2, 2026
The Inn at Longwood Medical
Indoor pool
Hampton Inn & Suites Boston/Waltham

Hampton Inn & Suites Boston/Waltham

Hampton Inn & Suites Boston/Waltham
2.5 star property
14.6 km from Medical Center Area
9.4 out of 10, Exceptional, (1571)
"Staff was friendly, place was clean, room was good. "
United States
Donald
The price is ₩126,082
₩140,833 total
includes taxes & fees
Dec 21 - Dec 22
Hampton Inn & Suites Boston/Waltham
Exterior
Nantasket Beach Resort

Nantasket Beach Resort

Nantasket Beach Resort
3.0 star property
21.1 km from Medical Center Area
8.6 out of 10, Excellent, (1000)
"Lovely place to stay!"
United States
Patrice
The price is ₩174,583
₩225,778 total
includes taxes & fees
Dec 29 - Dec 30
Nantasket Beach Resort
Exterior
The Cove At Salem

The Cove At Salem

The Cove At Salem
3.0 star property
28 km from Medical Center Area
9.4 out of 10, Exceptional, (843)
"Room was spotless and very accommodating for our visit. "
United States
Jessica
The price is ₩171,433
₩191,492 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Cove At Salem
Free daily buffet breakfast
HYATT house Boston/Waltham

HYATT house Boston/Waltham

HYATT house Boston/Waltham
3.0 star property
14.1 km from Medical Center Area
8.8 out of 10, Excellent, (1067)
"The Staff was great, the room was clean and comfortable and the breakfast was good! "
United States
Meridith
The price is ₩144,493
₩161,398 total
includes taxes & fees
Dec 20 - Dec 21
HYATT house Boston/Waltham
Terrace/patio
Sonesta Select Boston Danvers

Sonesta Select Boston Danvers

Sonesta Select Boston Danvers
3.0 star property
27.6 km from Medical Center Area
8.6 out of 10, Excellent, (1009)
"Great place to stay"
United States
Juanita Diaz
The price is ₩161,176
₩180,034 total
includes taxes & fees
Dec 18 - Dec 19
Sonesta Select Boston Danvers
2 restaurants, breakfast, lunch, dinner served; American cuisine
Hawthorne Hotel

Hawthorne Hotel

Hawthorne Hotel
3.5 star property
26.9 km from Medical Center Area
9.4 out of 10, Exceptional, (1512)
"Great customer service, very clean rooms and amazing food! Will definitely be staying here again! "
United States
Samantha
Hawthorne Hotel
Exterior
Holiday Inn Express & Suites Boston South - Randolph by IHG

Holiday Inn Express & Suites Boston South - Randolph by IHG

Holiday Inn Express & Suites Boston South - Randolph by IHG
2.5 star property
19.9 km from Medical Center Area
8.8 out of 10, Excellent, (1002)
"It was a great stay. Beautiful room. "
United States
Silvana
The price is ₩128,941
₩144,028 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express & Suites Boston South - Randolph by IHG
Terrace/patio
Hampton Inn Boston Woburn

Hampton Inn Boston Woburn

Hampton Inn Boston Woburn
2.5 star property
18.1 km from Medical Center Area
9.0 out of 10, Wonderful, (1340)
"Very good room and great breakfast!"
United States
Rodrigo
The price is ₩152,006
₩169,791 total
includes taxes & fees
Dec 19 - Dec 20
Hampton Inn Boston Woburn
Exterior
Seaport Hotel Boston

Seaport Hotel Boston

Seaport Hotel Boston
4.0 star property
Seaport District, 5.3 km from Medical Center Area
9.6 out of 10, Exceptional, (3785)
"Great weekend stay!"
United States
Amanda
The price is ₩247,845
₩295,934 total
includes taxes & fees
Dec 24 - Dec 25
Seaport Hotel Boston
Terrace/patio
Omni Boston Hotel at the Seaport

Omni Boston Hotel at the Seaport

Omni Boston Hotel at the Seaport
5.0 star property
Seaport District, 5.1 km from Medical Center Area
9.2 out of 10, Wonderful, (4283)
"Awesome stay. "
United States
Xavier
The price is ₩264,822
₩368,108 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Omni Boston Hotel at the Seaport
Meeting facility
Aloft by Marriott, Boston Seaport District

Aloft by Marriott, Boston Seaport District

Aloft by Marriott, Boston Seaport District
3.0 star property
Seaport District, 4.9 km from Medical Center Area
9.0 out of 10, Wonderful, (1372)
"Room was nice and clean reception staff was very friendly."
United States
Ede
The price is ₩151,711
₩219,545 total
includes taxes & fees
Dec 21 - Dec 22
Aloft by Marriott, Boston Seaport District
Exterior
The Westin Boston Seaport District

The Westin Boston Seaport District

The Westin Boston Seaport District
4.0 star property
Seaport District, 5 km from Medical Center Area
9.2 out of 10, Wonderful, (2320)
"Nice hotel and great location."
United States
James Earl
The price is ₩165,645
₩244,081 total
includes taxes & fees
Dec 24 - Dec 25
The Westin Boston Seaport District
Exterior
Holiday Inn Express Boston - Saugus by IHG

Holiday Inn Express Boston - Saugus by IHG

Holiday Inn Express Boston - Saugus by IHG
3.0 star property
16.1 km from Medical Center Area
8.6 out of 10, Excellent, (1001)
"Nice hotel near everything "
United States
Patricia
The price is ₩127,476
₩142,392 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express Boston - Saugus by IHG
Deluxe Room, 2 Double Beds (Bath in Room) | Premium bedding, down comforters, pillowtop beds, in-room safe
The Revolution Hotel

The Revolution Hotel

The Revolution Hotel
3.5 star property
2.8 km from Medical Center Area
9.0 out of 10, Wonderful, (2320)
"Clean, great staff, good food, great location!!!"
United States
Rafael
The Revolution Hotel
Restaurant
Hampton Inn & Suites Boston Crosstown Center

Hampton Inn & Suites Boston Crosstown Center

Hampton Inn & Suites Boston Crosstown Center
3.0 star property
2.6 km from Medical Center Area
7.8 out of 10, Good, (1438)
"Good front desk, better breakfast."
United States
HONGIL
The price is ₩127,769
₩148,788 total
includes taxes & fees
Dec 24 - Dec 25
Hampton Inn & Suites Boston Crosstown Center
Exterior
Lakeside Inn

Lakeside Inn

Lakeside Inn
2.0 star property
19.7 km from Medical Center Area
7.6 out of 10, Good, (2325)
"Great value right on lakefront and super nice staff!! "
United States
jay
Lakeside Inn
Lobby
Homewood Suites by Hilton Boston Seaport District

Homewood Suites by Hilton Boston Seaport District

Homewood Suites by Hilton Boston Seaport District
3.0 star property
Seaport District, 5.4 km from Medical Center Area
9.2 out of 10, Wonderful, (1380)
"Very clean and a family atmosphere"
United States
Maryanne
The price is ₩189,309
₩217,611 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Homewood Suites by Hilton Boston Seaport District
Property entrance
Copley House

Copley House

Copley House
3.0 star property
Prudential - St. Botolph, 2 km from Medical Center Area
9.0 out of 10, Wonderful, (1929)
"Fantastic place to stay and visit Boston."
United States
Poorvajan
Copley House
Exterior
Holiday Inn Express Boston - Waltham by IHG

Holiday Inn Express Boston - Waltham by IHG

Holiday Inn Express Boston - Waltham by IHG
2.5 star property
14.4 km from Medical Center Area
9.0 out of 10, Wonderful, (1001)
"Very nicely place to stay. "
United States
Sara
The price is ₩123,725
₩138,201 total
includes taxes & fees
Dec 18 - Dec 19
Holiday Inn Express Boston - Waltham by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Medical Center Area

Find the best Medical Center Area areas and neighborhoods for the activities you enjoy most.
Downtown Boston which includes night scenes and a city as well as a small group of people

Downtown Boston

Densely packed with highrise buildings, this area boasts landmarks like Custom House Tower and is close to Quincy Market, Faneuil Hall, and the Old State House. Find headquarters of major banks, hotels, and investment firms here.

Seaport District which includes a city, a river or creek and a high rise building

Seaport District

Experience a transformed industrial area with office towers, innovation labs, and 78 restaurants. Visit the Institute of Contemporary Art and easily access Downtown Boston via the Evelyn Moakley Bridge.

Back Bay featuring a city, heritage architecture and street scenes

Back Bay

Victorian brownstone homes and cultural institutions like the Boston Public Library define this area. Shop at Newbury Street, Prudential Center, and Copley Place, or explore sights like Trinity Church and the John Hancock Tower.

Beacon Hill which includes landscape views

Beacon Hill

Historic Federal-style rowhouses, gaslit streets, and brick sidewalks create a charming atmosphere. Explore the Boston African American National Historic Site, shop on Charles Street, and easily access MBTA stations.

Boston Harbor which includes performance art, music and a bay or harbor

North End

Indulge in Italian cuisine at numerous restaurants and bakeries, explore historic sites like Old North Church and Paul Revere House, and enjoy performances at NEMPAC and Improv Asylum Theater. Easily accessible via MBTA lines, buses, and ferries.

Top Medical Center Area Hotel Reviews

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Frequently asked questions

What's it like in Medical Center Area?
Guests are sure to enjoy their time checking out all that Boston's Medical Center Area neighborhood has to offer. Be sure to check out Isabella Stewart Gardner Museum and Warren Anatomical Museum as part of your Medical Center Area travel plans.
What's a favorite hotel to stay in Medical Center Area?
Based on Expedia customer reviews, The Inn at Longwood Medical is the highest ranked property in Medical Center Area. This hotel is a short 1-minute walk from Children's Hospital Boston, and it offers a restaurant and a fitness center.
How many hotels are there in Medical Center Area?
When you want to kick up your feet after a day of exploring the sights in Boston, you can choose from 17 Expedia hotels and other accommodations in Medical Center Area.
If I need to cancel my hotel reservation in Medical Center Area, will I receive a refund?
Yes, most hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to get the best deals available in Medical Center Area.
Where can I learn more about changing or cancelling my trip to Medical Center Area?
For more information about updating your trip to Medical Center Area or cancelling it, go to https://www.expedia.com/service/.
What can I see and do in this Boston neighborhood?
Sights like Isabella Stewart Gardner Museum and Warren Anatomical Museum can be part of your cultural tour of Medical Center Area. When you're sightseeing in Boston, Fenway Park and Copley Square are also worth a stop.
How can I get around Medical Center Area and the greater Boston area?
If you want to see more of the city, Longwood Medical Area Station is the closest metro stop. Others nearby include Brigham Circle Station and Museum of Fine Arts Station.