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Find Resorts & Hotels with Spas in Northeast Missouri, MO

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Check availability on Northeast Missouri Resorts & Hotels with Spas

Tonight
Oct 22 - Oct 23
Tomorrow
Oct 23 - Oct 24
This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Our top choices for Northeast Missouri hotels with a spa

A wooden interior with a hot tub, a wheelchair-accessible bench, and a window.
A hotel reception area with a wooden reception desk, a red chair, and a carpeted floor.
A Comfort Inn & Suites hotel with a stone facade, a covered entrance, and a clear blue sky.
A hotel room with a bed, a sofa, a desk, and a lamp.

1. Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
Hannibal
  • Serene spa sanctuary awaits in the heart of Hannibal with rejuvenating hot tub, indoor pool, and hydromassage showers.
₩104,062
₩124,015 total
includes taxes & fees
Nov 15 - Nov 16
Comfort Inn & Suites - Hannibal
A modern reception area with a marble counter, a wooden panel with a light fixture, a fireplace, and a seating area with a sofa and chairs.
An outdoor patio with tables and chairs, green umbrellas, and string lights.
A Holiday Inn hotel with a modern facade, a covered entrance, and landscaped areas with shrubs.
A spacious lobby with a fireplace, seating area, and large windows.

2. Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
Quincy
  • Revitalizing spa treatments await at this hotel, where an indoor pool, cozy pillow menus, and attentive staff create a relaxing retreat.
₩147,258
₩167,845 total
includes taxes & fees
Nov 22 - Nov 23
Holiday Inn Quincy East by IHG
A bathroom with a white sink, dark wooden door, and a shower area with striped glass walls.
A two-story building with a dark entrance, large windows, and a brick facade.
A modern interior with a staircase, a large abstract painting, and a seating area with a glass coffee table.
A room with a green armchair, a round table, a lamp, and a mirror on the wall.

3. Truitt Hotel

Truitt Hotel
Lafayette Square
₩222,877
₩270,557 total
includes taxes & fees
Oct 25 - Oct 26
Truitt Hotel
A modern spa with a curved reception desk, a large mirror, and a decorative water feature.
An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.
A bar area with multiple seating arrangements, a stage, and a chandelier.
A bakery display case with various pastries and cakes.

4. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
  • Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
₩211,203
₩268,844 total
includes taxes & fees
Nov 16 - Nov 17
Ameristar Casino Resort and Spa
A reception desk with a wooden finish and the name "IDOL WOLF" on it.
A reception area with a curved wooden desk, a laptop, and a chair. The wall has a sign reading "Locust Street Athletic and Swim Club."
A modern bathroom with a bathtub, a vanity with a mirror, and a shower area.
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.

5. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
Downtown West
  • Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
₩190,573
₩229,468 total
includes taxes & fees
Nov 15 - Nov 16
21C Museum Hotel St Louis
A spa area with a massage table, a hot tub, and a grill.
A living room with a fireplace, a dining area with a round table, and a balcony with a view.
A hot tub with a view of a forest, a bath brush, and a robe hanging on the wall.
A row of houses with a driveway leading to a gated entrance.

6. Hermann Hill

Hermann Hill
Hermann
  • Riverside bed and breakfast with private hot tubs and spa treatments offers romantic rejuvenation.
₩403,965
₩464,460 total
includes taxes & fees
Nov 2 - Nov 3
Hermann Hill
A modern kitchen with wooden cabinets, a central island, and framed artwork on the walls.
An outdoor seating area with modern furniture, a bar, and large windows offering views of a cityscape.
An indoor dining area with a long table, chairs, hanging plants, and a view of a brick building through large windows.
A bar area with leather seating, a bar counter, and shelves of bottles.

7. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
Clayton
  • Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
₩768,130
₩896,696 total
includes taxes & fees
Nov 1 - Nov 2
The Ritz-Carlton, St. Louis
A couple relaxing by a window overlooking a bridge and water.
A modern dining area with a long table set for a meal, large windows offering a view of a bridge, and a stone accent wall.
A bar area with a bartender, a bar counter with various bottles, and a view of the Gateway Arch.
A modern hotel lobby with a glass facade, seating area, and a staircase.

8. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
Downtown St. Louis
  • Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
₩497,494
₩581,710 total
includes taxes & fees
Oct 26 - Oct 27
Four Seasons Hotel St Louis
View all properties

Choose what matters most at spa hotels in Northeast Missouri

Pool
Breakfast included
Hot tub
4 stars
5 stars

Spa hotels with free breakfast in Northeast Missouri

A hotel room with a bed, a sofa, a desk, and a lamp.
A Comfort Inn & Suites hotel with a stone facade, a covered entrance, and a clear blue sky.
A restaurant with multiple tables and chairs, an exit sign, and a counter area.
An indoor swimming pool with wooden walls, a tiled floor, and a sign indicating no diving is allowed.

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
Hannibal
₩104,062
₩124,015 total
includes taxes & fees
Nov 15 - Nov 16
Comfort Inn & Suites - Hannibal
A modern reception area with a marble counter, a wooden panel with a light fixture, a fireplace, and a seating area with a sofa and chairs.
An outdoor patio with tables and chairs, green umbrellas, and string lights.
A Holiday Inn hotel with a modern facade, a covered entrance, and landscaped areas with shrubs.
A spacious lobby with a fireplace, seating area, and large windows.

Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
Quincy
₩147,258
₩167,845 total
includes taxes & fees
Nov 22 - Nov 23
Holiday Inn Quincy East by IHG
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.
A spacious lobby with multiple seating areas, a pool table, and artwork on the walls.
A spacious lobby with a large spherical sculpture, a seating area, and a view of the outside through a large window.
A reception desk with a wooden finish and the name "IDOL WOLF" on it.

21C Museum Hotel St Louis

21C Museum Hotel St Louis
Downtown West
₩190,573
₩229,468 total
includes taxes & fees
Nov 15 - Nov 16
21C Museum Hotel St Louis
A hot tub, a fire pit, and a view of a lake.
A bathroom with a bathtub, a shower, and a vanity with a mirror.
A row of houses with a driveway leading to a gated entrance.
A hotel room with a large bed, a bathtub, and a view of the outdoors.

Hermann Hill

Hermann Hill
Hermann
₩403,965
₩464,460 total
includes taxes & fees
Nov 2 - Nov 3
Hermann Hill
An indoor dining area with a long table, chairs, hanging plants, and a view of a brick building through large windows.
A bar area with leather seating, a bar counter, and shelves of bottles.
An outdoor seating area with modern furniture, a bar, and large windows offering views of a cityscape.
A lobby with a fireplace, two armchairs, a round table, and a bench.

The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
Clayton
₩768,130
₩896,696 total
includes taxes & fees
Nov 1 - Nov 2
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Northeast Missouri Hotel Reviews

Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent
"We have stayed here a few times, staff is top notch. Front desk and support staff are always helpful and polite. Motel is clean and quiet, breakfast is very good."
Jennifer 1-night trip
Posted 1 hour ago
Pear Tree Inn St. Louis Near Union Station
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

8/10 Good
"Breakfast is awesome and definitely worth it. However, this hotel is very outdated, very chopped up floor plan and would definitely be elevated by a remodel."
Stephanie 3-night trip
Posted 1 hour ago
Clayton Plaza Hotel & Extended Stay
Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"This is always my favorite place to stay. It's walking distance to the Aquarium and Enterprise Center. There is also so much close by if you need to run out for something. The breakfast is amazing and the evening kick back is an added bonus! When we were there this past weekend Nico was working the drinks and he was so amazing! If you go and he's there make sure you leave him a tip! Everyone is always so nice and helpful as well. I would def recommend this hotel to friends and family!"
Sheena 3-night trip
Posted 2 hours ago
Drury Plaza Hotel St. Louis Union Station
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

10/10 Excellent
"Room was quite large and very comfortable."
Barbara 3-night trip
Posted 22 hours ago
Ameristar Casino Resort and Spa

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