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21C Museum Hotel St Louis

4.5 star property
Contemporary art meets comfort at this downtown St. Louis hotel where travelers can unwind after exploring nearby Busch Stadium and other iconic attractions

Choose dates to view prices

21C Museum Hotel St Louis stands in the heart of the city, offering travelers a refined experience with its indoor pool and fitness center. Guests can book a massage at the spa, play billiards at the bar, or start their day with a cooked-to-order breakfast at the coffee shop.

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning
The current price is ₩255,726
₩306,583 total
includes taxes & fees
Jun 7 - Jun 8

Room options

Available filters for rooms
Showing 10 of 10 rooms

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(112 reviews)
  • 29 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(35 reviews)
  • 39 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Room (Bunk Bed)

Room (Bunk Bed) | In-room safe, desk, laptop workspace, blackout drapes

Room (Bunk Bed)

8.4 out of 10
Very good
(7 reviews)
  • 22 sq m
  • Sleeps 2
  • 1 Twin Bunk Bed
  • Free WiFi

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Loft, 2 Queen Beds

9.0 out of 10
Wonderful
(2 reviews)
  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 25 sq m
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Library)

  • City view
  • 68 sq m
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout drapes

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(2 reviews)
  • 51 sq m
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed
  • Free WiFi

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed
  • Free WiFi

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About the neighborhood

Located in St. Louis, 21C Museum Hotel St Louis is in the city center. St. Louis Union Station and Gateway Arch are notable landmarks, and the area's natural beauty can be seen at Mississippi River and Forest Park. Check out an event or a game at Busch Stadium, and consider making time for St. Louis Zoo, a top attraction not to be missed. Visit our St. Louis travel guide
Map
1528 Locust street, St. Louis, MO, 63103

What's nearby

  • Washington Avenue Historic District
    Washington Avenue Historic District
    2 min walk - 0.2 km
  • City Museum
    City Museum
    5 min walk - 0.4 km
  • Union Station, St. Louis, MO
    St. Louis Union Station
    8 min walk - 0.7 km
  • Aerial view of vibrant downtown St. Louis with Enterprise Center and St. Louis Wheel, St. Louis, Missouri, United States.
    Enterprise Center
    8 min walk - 0.7 km
  • St. Louis Aquarium at Union Station
    11 min walk - 1.0 km

Getting around

  • 8th and Pine Station
    13 min walk
  • St. Louis Gateway Station
    14 min walk
  • St. Louis Lambert Intl. Airport (STL)
    24 min drive

Restaurants

  • Budweiser Kiel Club
    6 min walk
  • Imo's Pizza Headquarters & Retail Store
    7 min walk
  • City Museum Rooftop Cafe
    5 min walk
  • Rosalita's Cantina
    6 min walk
  • Blood & Sand
    2 min walk

About this property

21C Museum Hotel St Louis

  • Luxury hotel near Enterprise Center
  • Located close to St. Louis Union Station and Busch Stadium, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services, and a bar. Treat yourself to a massage or other spa services. In addition to a gym and a business center, guests can connect to free in-room WiFi.
  • You'll also enjoy the following perks during your stay:
    • An indoor pool
    • Cooked-to-order breakfast (surcharge), valet parking (surcharge), and an elevator
    • A billiards/pool table, a vending machine, and smoke-free premises
    • Luggage storage, ATM/banking services, and meeting rooms
    • Guest reviews speak highly of the dining options, pool, and helpful staff
  • Room features
  • All 104 rooms include comforts such as laptop-friendly workspaces and air conditioning, as well as perks like free WiFi and desk chairs. Guest reviews highly rate the clean rooms at the property.
  • More amenities include:
    • Free toiletries and hair dryers
    • Flat-screen TVs with premium channels
    • Wardrobes/closets, heating, and daily housekeeping

Awards and affiliations

  • Eco-Certified Property
  • This property participates in Green Key Global, a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM

Late check-in subject to availability

Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100 per accommodation, per stay

Service animals are welcome, and are exempt from fees

Welcoming dogs only

Children and extra beds

Children are welcome

Rollaway/extra beds are not available

Cribs (infant beds) are not available

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Frequently asked questions

Does 21C Museum Hotel St Louis have a pool?

Yes, this property has an indoor pool.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Jun 2, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Jun 7, 2026 start from ₩255,726, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is 21C Museum Hotel St Louis pet-friendly?

Yes, dogs are allowed at this property. There's a fee of USD 100 per accommodation, per stay. Service animals are exempt from fees.

How much is parking?

Valet parking is available for USD 50 per day.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM. Late check-in is available during limited hours.

What time is check-out at 21C Museum Hotel St Louis ?

Check-out is at 11:00 AM.

Where is 21C Museum Hotel St Louis located?

Located in Downtown West, this luxury hotel is within a 10-minute walk of Washington Avenue Historic District, St. Louis Union Station, and City Museum. Enterprise Center and America's Center Convention Complex are also within 15 minutes. 8th and Pine Station is 13 minutes by foot and Convention Center Station is 15 minutes.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

21C Museum Hotel St Louis Reviews

9.0

Wonderful

9.2

Cleanliness

9.0

Amenities

9.0

Staff & service

9.2

Property conditions & facilities
Rating 10 - Excellent. 1318 out of 1876 reviews
Rating 8 - Good. 288 out of 1876 reviews
Rating 6 - Okay. 136 out of 1876 reviews
Rating 4 - Poor. 62 out of 1876 reviews
Rating 2 - Terrible. 72 out of 1876 reviews

Reviews

Verified

10/10 Excellent

Matthew

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very nice classic clean hotel
Stayed 1 night in May 2026
Verified

10/10 Excellent

Elizabeth

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The rooms were clean and common areas well maintained. Breakfast was the best and the staff were all helpful and very kind to all guests. It was the best stay I've had in a hotel.
Stayed 1 night in May 2026
Verified

10/10 Excellent

Brigitte

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
As a first time guest, I absolutely loved the entire experience. Being able to view the art on display, enjoy the arty decor throughout the hotel was a pleasure. We stayed in Deluxe King room.The room was nice and quiet, clean, welcoming and the shower stall is spacious.
Stayed 3 nights in May 2026
Verified

10/10 Excellent

Salvatore

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room are clean
Stayed 1 night in May 2026
Verified

10/10 Excellent

Jared

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
ABSOLUTELY PERFECT STAY! We loved the bar downstairs and the museum exhibit was perfect. We love the room, the game room, and the staff 10/10 recommend and will be staying again
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

Amanda

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Absolutely beautiful, amazing breakfast, comfy bed!
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Donna

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great hotel with a friendly staff. The on-site restaurant is a great spot fir a cocktail after a day of exploring.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Chad

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
A fantastic stay. Great breakfast and excellent pool area. Would stay again
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Donna

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Enjoyed my stay. A very artsy hotel including art gallery. Excellent restaurant and bar. Excellent staff.
Stayed 3 nights in Apr 2026
Verified

10/10 Excellent

Mike

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful place, friendly staff! Enjoyed our stay and will definitely come back!!!
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Demetric

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The hotel bedrooms were amazing. The aesthetic was immaculate, and the amenities were very pleasing.
Stayed 2 nights in Apr 2026
Verified

10/10 Excellent

Natalie

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful, repurposed hotel with gorgeous lobby, amazing art museum, top-notch pool and spa facilities, central location, and very comfortable and compact room. We will definitely stay here again if we find another great deal!
Stayed 1 night in Apr 2026
Verified

10/10 Excellent

SHELLY

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved this hotel. Staff was amazing. Happy hour and food was very good. Only issue is that there is not much to do directly around hnotel...only a short walk to restaurants and hockey arena..so not awful.. Staff was so nice and hotel is very cool.
Stayed 2 nights in Apr 2026
Verified

6/10 Okay

Kendra

Liked: Cleanliness, staff & service, property conditions & facilities
It wasn't a bad stay. It was a clean hotel and the staff was nice. My only complaint it is that it didn't look like the pictures. Online this looks a lot more luxurious than it is. Not saying it's bad, but in person, it definitely gives renovated YMCA.
Stayed 2 nights in May 2026
Verified

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
My room was perfect , breakfast and coffee in restaurant was great and I would stay there again because it was conveniently located to walk . I was in town for the marathon.
Stayed 2 nights in Apr 2026
Verified

8/10 Good

Muriel

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room excellent and large with great decor and amenities like robes!
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Susan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I love the history of the hotel. My kids liked the pool and the hot tub was huge. My husband enjoyed the complimentary drink at the bar and tried something new. The art exhibit was neat as well. It was walking distance to everything we needed. Would definitely stay again!
Great bar atmosphere
Close to attractions
This guy kept moving around the hall
Stayed 2 nights in Apr 2026
Verified

10/10 Excellent

Kelly

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We had a great stay at the Museum hotel! Place was gorgeous, room very clean & the staff was wonderful! Highly recommend!
Stayed 3 nights in Mar 2026
Verified

10/10 Excellent

Stephanie

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Gorgeous amenities. Room was tiptop shape! Food was good.
Stayed 3 nights in Mar 2026
Verified

10/10 Excellent

Robert

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This is a unique property. Pool and health club are incredible.
Stayed 2 nights in Apr 2026
Verified

10/10 Excellent

Shari

Clean room. Excellent staff!
Stayed 1 night in Mar 2026
Verified

8/10 Good

Kristen

Liked: Cleanliness, staff & service, amenities
Friendly staff, beautiful atmosphere, modern finishes.
Stayed 1 night in Feb 2026
Verified

2/10 Terrible

Hossein

Disliked: Cleanliness, staff & service, amenities, property conditions & facilities
Didn’t feel good and wasn’t taking care of. Self service!
Stayed 1 night in May 2026
Verified

10/10 Excellent

Robert

Liked: Cleanliness, amenities, property conditions & facilities
Great service. Would definitely stay again
Stayed 1 night in Feb 2026
Verified

8/10 Good

Valerie

Liked: Staff & service, amenities
Nice room, the hot tub and steam room were fantastic. The staff were friendly and it was convenient to have coffee right downstairs.
Stayed 4 nights in Feb 2026