A white colonial church with ornate architecture and a large wooden door.

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Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

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Our top choices for Santa Ana hotels

A lush garden with neatly trimmed hedges forming a pathway, surrounded by dense greenery and a mountainous backdrop.

1. Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (26 reviews)
"This place has two parts, the hotel and a hostel, I stayed in the private room of the hostel part, it wasn’t very good, but the whole place is very nice, like an oasis with a lot of plants, the hotel Part would be very nice."
United States
SUSAN
The price is ₩51,811
₩63,209 total
includes taxes & fees
Oct 15 - Oct 16
Hostal Casa Buho
A rooftop with a red roof, a white railing, and a view of a mountainous landscape.

2. Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
6.0 out of 10, (1 review)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is ₩18,123
₩38,767 total
includes taxes & fees
Sep 25 - Sep 26
Castillo De Los Gigantes
A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

3. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
The price is ₩138,324
₩168,755 total
includes taxes & fees
Sep 25 - Sep 26
Villas Santa Ana-Ricardo
Hotel Villa Colonial with a colonial architectural style, featuring a large arched entrance and a signboard.

4. Villa Colonial

Villa Colonial
3.0 star property
0.7 km from Santa Ana
9.2 out of 10, Wonderful, (216 reviews)
"The whole experience was good"
United States
Mercedes
The price is ₩115,878
₩141,371 total
includes taxes & fees
Sep 30 - Oct 1
Villa Colonial

5. Hotel Genessis

Hotel Genessis
3.5 star property
0.9 km from Santa Ana
9.2 out of 10, Wonderful, (147 reviews)
"Excellent hotel! So happy we chose Hotel Genessis for our stay. Its location is convenient, breakfast was great, and staff were super sweet."
United States
Jasmine
The price is ₩133,180
₩162,478 total
includes taxes & fees
Sep 26 - Sep 27
Hotel Genessis
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

6. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (923 reviews)
"Excelent place"
United States
Gaston
The price is ₩100,625
₩122,763 total
includes taxes & fees
Sep 27 - Sep 28
El Carmen Hotel
An outdoor seating area with tables and chairs, surrounded by a tree and string lights.

7. Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (249 reviews)
"The staff was very friendly and the room and surrounding property were very pretty and clean"
United States
Logan
The price is ₩116,576
₩142,223 total
includes taxes & fees
Sep 27 - Sep 28
Casa Noble Hotel
A restaurant with a brick wall, wine racks, and tables set for dining.

8. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,000 reviews)
"Great breakfast."
Canada
Harvey
The price is ₩201,116
₩253,554 total
includes taxes & fees
Sep 27 - Sep 28
Los Pasos Boutique Hotel & Spa
A room with two beds, a wooden ceiling, and tiled flooring.

9. Hotel Casa Colonial by AHS

Hotel Casa Colonial by AHS
3.0 star property
Historic Center, 1.3 km from Santa Ana
8.6 out of 10, Excellent, (15 reviews)
"Amazing hotel, definitely recommend, bit higher price but for a good reason."
United States
elijah
The price is ₩56,794
₩69,288 total
includes taxes & fees
Sep 28 - Sep 29
Hotel Casa Colonial by AHS
A pool area with a stone archway, a small waterfall, and a view of a building with a balcony.

10. Hotel Posada del Angel

Hotel Posada del Angel
4.0 star property
1 km from Santa Ana
9.6 out of 10, Exceptional, (318 reviews)
"Friendly staff, nice breakfast downstairs or on the rooftop, comfortable and relaxing stay."
United States
Michael
The price is ₩262,925
₩320,769 total
includes taxes & fees
Sep 29 - Sep 30
Hotel Posada del Angel
A corner with two upholstered chairs, a small round table, and a potted plant.

11. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (458 reviews)
"Excellent location. Staff friendly and helpful."
United States
Martin
The price is ₩115,106
₩140,430 total
includes taxes & fees
Sep 29 - Sep 30
Ciel-Luxe Hotels
A covered outdoor area with a stone staircase, lush greenery, and a seating area with tables and chairs.

12. Hotel Eterna Primavera Antigua

Hotel Eterna Primavera Antigua
3.0 star property
Historic Center, 1.1 km from Santa Ana
8.8 out of 10, Excellent, (323 reviews)
"Good parking option and breakfast included"
United States
Carlos
The price is ₩103,680
₩126,490 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Eterna Primavera Antigua
A covered corridor with tiled flooring, potted plants, and a wooden bench.

13. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (804 reviews)
"Very nice hotel!"
United States
Katie
The price is ₩122,872
₩149,904 total
includes taxes & fees
Sep 28 - Sep 29
Hotel Las Farolas
A rooftop terrace with outdoor seating, a fire feature, and a view of a mountain.

14. Las Cruces Boutique Hotel

Las Cruces Boutique Hotel
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.8 out of 10, Exceptional, (276 reviews)
"Excellent location, delicious breakfast, nice garden, friendly staff."
United States
Liang
The price is ₩243,954
₩297,624 total
includes taxes & fees
Sep 29 - Sep 30
Las Cruces Boutique Hotel
A corridor with tiled flooring, wooden benches, and potted plants.

15. Hotel Meson del Valle by AHS

Hotel Meson del Valle by AHS
3.0 star property
1.2 km from Santa Ana
8.6 out of 10, Excellent, (541 reviews)
"The staff was very helpful, the trim was cleaned and the location very convenient."
United States
JUANCARLO
The price is ₩57,735
₩70,437 total
includes taxes & fees
Sep 28 - Sep 29
Hotel Meson del Valle by AHS
A cozy room with a round table, striped armchairs, and a potted plant.

16. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,001 reviews)
"Very clean room staff was very helpful with accommodations and I would come back again"
United States
Simon
The price is ₩256,152
₩346,388 total
includes taxes & fees
Sep 27 - Sep 28
Hotel Camino Real Antigua
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

17. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,159 reviews)
"Outstanding staff and the hotel was beautiful"
United States
Mario
The price is ₩322,561
₩410,059 total
includes taxes & fees
Sep 29 - Sep 30
Hotel Museo Spa Casa Santo Domingo
A building with a covered patio area, a garden with various plants, and a hanging vine with purple flowers.

18. Hotel Aurora

Hotel Aurora
3.5 star property
Historic Center, 1.1 km from Santa Ana
9.6 out of 10, Exceptional, (426 reviews)
"Very close to everything, clean and beautiful"
United States
Mariceliz
The price is ₩102,138
₩124,609 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Aurora
A courtyard with stone walls, a fountain, and various plants and flowers.

19. Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (785 reviews)
"Excellent location helps to have short walking distance to all nearby highlights."
United States
jose
The price is ₩304,942
₩372,029 total
includes taxes & fees
Sep 29 - Sep 30
Hotel Posada de Don Rodrigo Antigua
A multi-level outdoor garden with potted plants and a wooden pergola structure.

20. Naif Boutique Hotel

Naif Boutique Hotel
3.0 star property
Historic Center, 1.4 km from Santa Ana
9.0 out of 10, Wonderful, (495 reviews)
"Great Service and breakfasts …"
United States
GIOVANNI
The price is ₩108,021
₩131,786 total
includes taxes & fees
Sep 27 - Sep 28
Naif Boutique Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Barceló Guatemala City

Barceló Guatemala City

10/10 Excellent
"Estuvo más allá de Value For Money, definitivamente no me quedo en otro lado en la ciudad que no sea este hotel. Desde el servicio, la comida, el desayuno, el tipo de habitación y el precio. Su localización hace sencillo llegar al aeropuerto y su transporte gratis lo hace muy conveniente."
Yuri 2-night trip
Posted 1 hour ago
Barceló Guatemala City

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on our traveler data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.