A white colonial church with ornate architecture and a large wooden door.

Find hotels in Santa Ana, Antigua Guatemala

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Ana hotels

A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

1. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
The price is ₩151,266
₩184,545 total
includes taxes & fees
Nov 8 - Nov 9
Villas Santa Ana-Ricardo
A cozy indoor space with a staircase, seating area, and various plants.

2. Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
8.0 out of 10, Very good, (2 reviews)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is ₩17,837
₩21,761 total
includes taxes & fees
Nov 6 - Nov 7
Castillo De Los Gigantes
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

3. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,192 reviews)
"Great stay. Spa is amazing"
United States
Julio
The price is ₩467,134
₩586,296 total
includes taxes & fees
Nov 9 - Nov 10
Hotel Museo Spa Casa Santo Domingo
A cobblestone courtyard with outdoor seating and umbrellas, surrounded by greenery and a building with a tiled roof.

4. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,000 reviews)
"Fabulous food, wonderful spa!!"
United States
Elizabeth
The price is ₩275,456
₩369,648 total
includes taxes & fees
Nov 8 - Nov 9
Hotel Camino Real Antigua
A garden pathway leading to a building with a green lawn and a clear blue sky.

5. Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.8 out of 10, Excellent, (1,000 reviews)
"Good place to stay"
United States
Michael
The price is ₩165,228
₩201,578 total
includes taxes & fees
Dec 1 - Dec 2
Hotel Soleil La Antigua
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

6. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (961 reviews)
"The breakfast and staff are incredible! Great location!"
United States
Jennifer
The price is ₩147,806
₩180,324 total
includes taxes & fees
Dec 1 - Dec 2
El Carmen Hotel
A hot tub with a waterfall feature, surrounded by brick walls and stone, with a view through a window.

7. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,000 reviews)
"Nice hotel friendly staff and helpful"
United States
Hilda
The price is ₩215,989
₩271,569 total
includes taxes & fees
Nov 16 - Nov 17
Los Pasos Boutique Hotel & Spa
An outdoor pool area with wooden decking, surrounded by lush greenery and potted plants.

8. Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,001 reviews)
"Very nice property, location was great and amenities were excellent."
United States
Oscar
The price is ₩261,071
₩318,507 total
includes taxes & fees
Nov 9 - Nov 10
Porta Hotel Antigua
A bedroom with a four-poster bed, two armchairs, a desk, and a nightstand.

9. El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (954 reviews)
"This hotel is incredible. If we ever go back to Antigua, we will stay here again! The staff go above and beyond to make your stay what you want it to be."
United States
Calvin
The price is ₩338,916
₩433,633 total
includes taxes & fees
Dec 6 - Dec 7
El Convento Boutique Hotel
A covered outdoor area with stone flooring, potted plants, and a wooden pergola.

10. San Rafael Hotel

San Rafael Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.8 out of 10, Exceptional, (501 reviews)
"We loved it!! The location is great. The room was amazing, the breakfast, the staff… everything was perfect."
Mexico
Francisco Benjamin Macias
The price is ₩278,196
₩343,431 total
includes taxes & fees
Dec 1 - Dec 2
San Rafael Hotel
A covered outdoor seating area with wicker furniture and hanging lights.

11. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (474 reviews)
"I had a great stay at Ciel Luxe Hotel! The room was clean and comfortable, the staff was friendly, and the location was convenient. I’d definitely stay here again!"
United States
Corey
The price is ₩113,907
₩138,967 total
includes taxes & fees
Nov 12 - Nov 13
Ciel-Luxe Hotels
A conservatory with a large window, a stone bench, and two chairs with cushions.

12. Meson Panza Verde

Meson Panza Verde
4.0 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (515 reviews)
"Great place to stay"
United States
Mauricio
The price is ₩185,510
₩226,322 total
includes taxes & fees
Nov 18 - Nov 19
Meson Panza Verde
A covered walkway with wooden pillars and tropical plants.

13. Good Hotel Antigua Guatemala, a Member of Design Hotels

Good Hotel Antigua Guatemala, a Member of Design Hotels
4.0 star property
0.8 km from Santa Ana
9.4 out of 10, Exceptional, (571 reviews)
"The hotel was very wonderful!! Saul Bistro connects to the hotel which was amazing and convenient. The staff was the best!! I can’t say enough great things about this place"
United States
Brandon Jordani
The price is ₩369,144
₩450,356 total
includes taxes & fees
Dec 1 - Dec 2
Good Hotel Antigua Guatemala, a Member of Design Hotels
An indoor courtyard with stone flooring, multiple seating areas, and string lights.

14. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (388 reviews)
"The staff was wonderful! The location was perfect! The hotel was beautiful! I would definitely recommend! There’s hot water, and WiFi!"
United States
Carlos
The price is ₩93,723
₩114,342 total
includes taxes & fees
Nov 22 - Nov 23
Hotel Casa Carmina by AHS
A modern, triangular wooden structure with a glass entrance, surrounded by lush greenery.

15. Santo Cielo by Casa Santo Domingo

Santo Cielo by Casa Santo Domingo
3.5 star property
0.9 km from Santa Ana
9.4 out of 10, Exceptional, (580 reviews)
"Great place and staff"
United States
Ricardo
The price is ₩285,400
₩364,581 total
includes taxes & fees
Nov 9 - Nov 10
Santo Cielo by Casa Santo Domingo
A garden with a pergola, potted plants, and a chair.

16. Casa Santa Rosa Hotel Boutique

Casa Santa Rosa Hotel Boutique
3.5 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (418 reviews)
"Delicious breakfast, nive place, close to everything, I really enjoyed staying there"
United States
Ligia
The price is ₩227,057
₩277,010 total
includes taxes & fees
Nov 9 - Nov 10
Casa Santa Rosa Hotel Boutique
A corridor with arches, tiled flooring, and potted plants.

17. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (812 reviews)
"Very nice hotel!"
United States
Katie
The price is ₩181,399
₩221,307 total
includes taxes & fees
Nov 8 - Nov 9
Hotel Las Farolas
A courtyard with stone walls, a fountain, and various plants and flowers.

18. Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (790 reviews)
"Excellent location helps to have short walking distance to all nearby highlights."
United States
jose
The price is ₩335,923
₩409,826 total
includes taxes & fees
Nov 6 - Nov 7
Hotel Posada de Don Rodrigo Antigua
A yellow building with a clock tower and an archway.

19. Hotel Convento Santa Catalina

Hotel Convento Santa Catalina
3.5 star property
Historic Center, 1.6 km from Santa Ana
8.2 out of 10, Very good, (679 reviews)
"Great hotel, great location !"
United States
christina
The price is ₩89,329
₩108,981 total
includes taxes & fees
Nov 30 - Dec 1
Hotel Convento Santa Catalina
A lobby with a central reception desk, potted cacti, a chandelier, and a view of the interior through an archway.

20. Mestizo Antigua

Mestizo Antigua
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (221 reviews)
"Staff was very friendly and accommodating. Highly recommend!"
United States
Lucy
The price is ₩211,403
₩257,911 total
includes taxes & fees
Nov 8 - Nov 9
Mestizo Antigua
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.
Villas Santa Ana-Ricardo
3.5 star property
9.0
Wonderful
17 reviews
View
A cozy indoor space with a staircase, seating area, and various plants.
Castillo De Los Gigantes
2.0 star property
8.0
Very good
2 reviews
View
A cobblestone courtyard with outdoor seating and umbrellas, surrounded by greenery and a building with a tiled roof.
Hotel Camino Real Antigua
4.0 star property
9.6
Exceptional
1,000 reviews
View
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.
Hotel Museo Spa Casa Santo Domingo
4.5 star property
9.4
Exceptional
1,192 reviews
View
A hot tub with a waterfall feature, surrounded by brick walls and stone, with a view through a window.
Los Pasos Boutique Hotel & Spa
4.5 star property
9.4
Exceptional
1,000 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

10/10 Excellent
"Beautiful grounds. Great customer service."
Tonya 1-night trip
Posted less than an hour ago
Hotel Museo Spa Casa Santo Domingo

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on our traveler data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.