A white colonial church with ornate architecture and a large wooden door.

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Check prices for these dates

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Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22

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Our top choices for Santa Ana hotels

A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

1. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
The price is ₩151,205
₩184,471 total
includes taxes & fees
Dec 6 - Dec 7
Villas Santa Ana-Ricardo
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

2. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,197 reviews)
"It was a great stay."
United States
Edgardo
The price is ₩470,103
₩589,912 total
includes taxes & fees
Dec 6 - Dec 7
Hotel Museo Spa Casa Santo Domingo
A courtyard with a tiled roof, a building with a dome, and a mountain in the background.

3. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,007 reviews)
"Everything was close to.. very nice staff and the property was amazing."
United States
Stephanie
The price is ₩275,502
₩369,710 total
includes taxes & fees
Nov 15 - Nov 16
Hotel Camino Real Antigua
A garden pathway leading to a building with a green lawn and a clear blue sky.

4. Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.8 out of 10, Excellent, (1,000 reviews)
"Good place to stay"
United States
Michael
The price is ₩178,116
₩217,302 total
includes taxes & fees
Dec 7 - Dec 8
Hotel Soleil La Antigua
A restaurant with a brick wall, wine racks, and tables set for dining.

5. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,001 reviews)
"Nice hotel friendly staff and helpful"
United States
Hilda
The price is ₩230,291
₩289,018 total
includes taxes & fees
Dec 6 - Dec 7
Los Pasos Boutique Hotel & Spa
A stone pathway leading to a central fountain, flanked by walls adorned with framed artwork.

6. Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,004 reviews)
"Very nice property, location was great and amenities were excellent."
United States
Oscar
The price is ₩307,431
₩375,066 total
includes taxes & fees
Dec 7 - Dec 8
Porta Hotel Antigua
A courtyard with a fountain, stone pathway, and seating area surrounded by greenery.

7. El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (958 reviews)
"What a beautiful hotel!"
United States
Kristen
The price is ₩326,184
₩418,096 total
includes taxes & fees
Dec 9 - Dec 10
El Convento Boutique Hotel
A covered outdoor seating area with wicker furniture and hanging lights.

8. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (477 reviews)
"I had a great stay at Ciel Luxe Hotel! The room was clean and comfortable, the staff was friendly, and the location was convenient. I’d definitely stay here again!"
United States
Corey
The price is ₩136,670
₩166,737 total
includes taxes & fees
Nov 12 - Nov 13
Ciel-Luxe Hotels
A covered outdoor area with stone flooring, potted plants, and a wooden pergola.

9. San Rafael Hotel

San Rafael Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.8 out of 10, Exceptional, (503 reviews)
"We loved it!! The location is great. The room was amazing, the breakfast, the staff… everything was perfect."
Mexico
Francisco Benjamin Macias
The price is ₩278,085
₩343,292 total
includes taxes & fees
Dec 1 - Dec 2
San Rafael Hotel
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

10. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (965 reviews)
"centrally located with a beautiful terrace view restaurant cant ask for more.."
United States
Miguel
The price is ₩161,026
₩196,452 total
includes taxes & fees
Dec 9 - Dec 10
El Carmen Hotel
An outdoor dining area with stone seating and tables, surrounded by lush greenery and a yellow building with a tiled roof.

11. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (814 reviews)
"Staff was very helpful, great location"
Canada
Florence
The price is ₩181,326
₩221,218 total
includes taxes & fees
Nov 17 - Nov 18
Hotel Las Farolas
An outdoor seating area with tables and chairs, surrounded by a tree and string lights.

12. Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (264 reviews)
"Fantastic hotel"
Canada
Alysha
The price is ₩127,075
₩155,031 total
includes taxes & fees
Dec 2 - Dec 3
Casa Noble Hotel
A stone building with arched entrances and a balcony with wrought iron railings.

13. Meson Panza Verde

Meson Panza Verde
4.0 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (521 reviews)
"We had a wonderful stay, everyone there is so kind and attentive. Definitely a place to return to and recommend to others."
United States
Erica
The price is ₩169,668
₩206,995 total
includes taxes & fees
Nov 22 - Nov 23
Meson Panza Verde
A covered outdoor seating area with a sofa, coffee table, and chairs, surrounded by potted plants and a stone wall.

14. Casa Santa Rosa Hotel Boutique

Casa Santa Rosa Hotel Boutique
3.5 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (419 reviews)
"Delicious breakfast, nive place, close to everything, I really enjoyed staying there"
United States
Ligia
The price is ₩227,123
₩277,090 total
includes taxes & fees
Nov 16 - Nov 17
Casa Santa Rosa Hotel Boutique
A rooftop terrace with outdoor seating, a fire feature, and a view of a mountain.

15. Las Cruces Boutique Hotel

Las Cruces Boutique Hotel
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.8 out of 10, Exceptional, (292 reviews)
"Beautiful rooms, very attentive staff, and delicious breakfast!"
United States
Miria
The price is ₩377,761
₩460,875 total
includes taxes & fees
Nov 30 - Dec 1
Las Cruces Boutique Hotel
An indoor courtyard with stone flooring, multiple seating areas, and string lights.

16. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (392 reviews)
"The staff was wonderful! The location was perfect! The hotel was beautiful! I would definitely recommend! There’s hot water, and WiFi!"
United States
Carlos
The price is ₩78,575
₩95,861 total
includes taxes & fees
Dec 9 - Dec 10
Hotel Casa Carmina by AHS
A covered walkway with wooden pillars and tropical plants.

17. Good Hotel Antigua Guatemala, a Member of Design Hotels

Good Hotel Antigua Guatemala, a Member of Design Hotels
4.0 star property
0.8 km from Santa Ana
9.4 out of 10, Exceptional, (571 reviews)
"The hotel was very wonderful!! Saul Bistro connects to the hotel which was amazing and convenient. The staff was the best!! I can’t say enough great things about this place"
United States
Brandon Jordani
The price is ₩351,518
₩428,852 total
includes taxes & fees
Dec 9 - Dec 10
Good Hotel Antigua Guatemala, a Member of Design Hotels
A poolside area with a seating arrangement and a small pool.

18. Pensativo House Hotel

Pensativo House Hotel
4.5 star property
1 km from Santa Ana
9.4 out of 10, Exceptional, (435 reviews)
"Our stay was wonderful and the staff was attentive and friendly."
United States
Caren
The price is ₩251,353
₩320,082 total
includes taxes & fees
Nov 30 - Dec 1
Pensativo House Hotel
A lush garden with a rock waterfall, potted plants, and a well-maintained lawn.

19. Hotel Camelias Inn by AHS

Hotel Camelias Inn by AHS
3.0 star property
Historic Center, 1.2 km from Santa Ana
8.8 out of 10, Excellent, (712 reviews)
"Amazing front desk team, very helpful and give us great tips."
United States
Carlos
The price is ₩81,193
₩99,055 total
includes taxes & fees
Nov 29 - Nov 30
Hotel Camelias Inn by AHS
A modern, triangular wooden structure with a glass entrance, surrounded by lush greenery.

20. Santo Cielo by Casa Santo Domingo

Santo Cielo by Casa Santo Domingo
3.5 star property
0.9 km from Santa Ana
9.4 out of 10, Exceptional, (581 reviews)
"Great place and staff"
United States
Ricardo
The price is ₩285,285
₩364,435 total
includes taxes & fees
Nov 12 - Nov 13
Santo Cielo by Casa Santo Domingo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.
Villas Santa Ana-Ricardo
3.5 star property
9.0
Wonderful
17 reviews
View
An outdoor seating area with tables and chairs, surrounded by a tree and string lights.
Casa Noble Hotel
3.0 star property
9.6
Exceptional
264 reviews
View
A corridor with a bench, potted plants, and a hanging light fixture.
Nico Hotel
3.0 star property
9.0
Wonderful
477 reviews
View
A courtyard with potted plants, a dining area with tables and chairs, and a staircase leading to an upper level.
Hotel La Galeria
3.0 star property
9.4
Exceptional
306 reviews
View
An indoor courtyard with stone flooring, multiple seating areas, and string lights.
Hotel Casa Carmina by AHS
4.0 star property
8.8
Excellent
392 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Hotel Biltmore Guatemala

Hotel Biltmore Guatemala

10/10 Excellent
"Staff is exceptional"
Luis 2-night trip
Posted 13 hours ago
Hotel Biltmore Guatemala

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on our traveler data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.