A white colonial church with ornate architecture and a large wooden door.

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Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

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Our top choices for Santa Ana hotels

A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

1. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
The price is ₩135,800
₩165,676 total
includes taxes & fees
Oct 6 - Oct 7
Villas Santa Ana-Ricardo
A lush garden with neatly trimmed hedges forming a pathway, surrounded by dense greenery and a mountainous backdrop.

2. Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (26 reviews)
"This place has two parts, the hotel and a hostel, I stayed in the private room of the hostel part, it wasn’t very good, but the whole place is very nice, like an oasis with a lot of plants, the hotel Part would be very nice."
United States
SUSAN
The price is ₩50,866
₩62,057 total
includes taxes & fees
Oct 19 - Oct 20
Hostal Casa Buho
A rooftop with a red roof, a white railing, and a view of a mountainous landscape.

3. Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
6.0 out of 10, (1 review)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is ₩17,793
₩38,060 total
includes taxes & fees
Oct 6 - Oct 7
Castillo De Los Gigantes
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

4. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,168 reviews)
"Outstanding staff and the hotel was beautiful"
United States
Mario
The price is ₩330,394
₩419,433 total
includes taxes & fees
Oct 6 - Oct 7
Hotel Museo Spa Casa Santo Domingo
A restaurant with a brick wall, wine racks, and tables set for dining.

5. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,000 reviews)
"Great breakfast."
Canada
Harvey
The price is ₩205,586
₩258,857 total
includes taxes & fees
Oct 27 - Oct 28
Los Pasos Boutique Hotel & Spa
A stone pathway leading to a central fountain, flanked by walls adorned with framed artwork.

6. Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,000 reviews)
"I loved my stay will be back my next time around"
United States
LESLIE A
The price is ₩216,230
₩263,801 total
includes taxes & fees
Oct 6 - Oct 7
Porta Hotel Antigua
A cozy room with a round table, striped armchairs, and a potted plant.

7. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,004 reviews)
"Very clean room staff was very helpful with accommodations and I would come back again"
United States
Simon
The price is ₩253,324
₩342,564 total
includes taxes & fees
Oct 7 - Oct 8
Hotel Camino Real Antigua
A bedroom with a four-poster bed, two armchairs, a desk, and a nightstand.

8. El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (942 reviews)
"Beautiful Hotel."
United States
KEVIN
The price is ₩375,295
₩477,965 total
includes taxes & fees
Oct 6 - Oct 7
El Convento Boutique Hotel
A garden pathway leading to a building with a green lawn and a clear blue sky.

9. Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.8 out of 10, Excellent, (1,001 reviews)
"It is a beautiful and quiet hotel. Perfect place for families."
United States
Johanna Elizabeth
The price is ₩163,006
₩198,868 total
includes taxes & fees
Oct 6 - Oct 7
Hotel Soleil La Antigua
A corner with two upholstered chairs, a small round table, and a potted plant.

10. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (461 reviews)
"Great hospitality"
United States
abdessamad
The price is ₩113,700
₩138,714 total
includes taxes & fees
Oct 6 - Oct 7
Ciel-Luxe Hotels
A stone building with arched entrances and a balcony with wrought iron railings.

11. Meson Panza Verde

Meson Panza Verde
4.0 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (507 reviews)
"Great place to stay"
United States
Mauricio
The price is ₩140,406
₩171,296 total
includes taxes & fees
Oct 27 - Oct 28
Meson Panza Verde
A rooftop terrace with outdoor seating, a fire feature, and a view of a mountain.

12. Las Cruces Boutique Hotel

Las Cruces Boutique Hotel
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.8 out of 10, Exceptional, (280 reviews)
"Beautiful rooms, very attentive staff, and delicious breakfast!"
United States
Miria
The price is ₩256,340
₩312,742 total
includes taxes & fees
Oct 7 - Oct 8
Las Cruces Boutique Hotel
A covered corridor with tiled flooring, potted plants, and a wooden bench.

13. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (807 reviews)
"Hotel was conveniently located. But the walls were really thin. We were in front of the restaurant and the main hall so you can hear EVERYTHING and Everyone. Overall ok hotel and convenient location."
United States
Erika
The price is ₩144,757
₩176,604 total
includes taxes & fees
Oct 19 - Oct 20
Hotel Las Farolas
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

14. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (931 reviews)
"Great breakfast and room service, affordable spa"
United States
Keishawn
The price is ₩105,885
₩129,179 total
includes taxes & fees
Oct 7 - Oct 8
El Carmen Hotel
A covered outdoor area with stone flooring, potted plants, and a wooden pergola.

15. San Rafael Hotel

San Rafael Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.8 out of 10, Exceptional, (495 reviews)
"We loved it!! The location is great. The room was amazing, the breakfast, the staff… everything was perfect."
Mexico
Francisco Benjamin Macias
The price is ₩237,307
₩293,536 total
includes taxes & fees
Oct 6 - Oct 7
San Rafael Hotel
A building with a covered patio area, a garden with various plants, and a hanging vine with purple flowers.

16. Hotel Aurora

Hotel Aurora
3.5 star property
Historic Center, 1.1 km from Santa Ana
9.6 out of 10, Exceptional, (428 reviews)
"Very close to everything, clean and beautiful"
United States
Mariceliz
The price is ₩100,274
₩122,334 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Aurora
A courtyard with stone walls, a fountain, and various plants and flowers.

17. Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (785 reviews)
"Excellent location helps to have short walking distance to all nearby highlights."
United States
jose
The price is ₩335,085
₩408,804 total
includes taxes & fees
Oct 6 - Oct 7
Hotel Posada de Don Rodrigo Antigua
A hotel room with two beds, a TV mounted on the wall, and a view of the outside balcony.

18. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (370 reviews)
"Great location, very friendly staff and very clean."
United States
Martha
The price is ₩54,284
₩66,226 total
includes taxes & fees
Oct 13 - Oct 14
Hotel Casa Carmina by AHS
A multi-level outdoor garden with potted plants and a wooden pergola structure.

19. Naif Boutique Hotel

Naif Boutique Hotel
3.0 star property
Historic Center, 1.4 km from Santa Ana
9.0 out of 10, Wonderful, (498 reviews)
"Great Service and breakfasts …"
United States
GIOVANNI
The price is ₩109,295
₩133,339 total
includes taxes & fees
Oct 6 - Oct 7
Naif Boutique Hotel
A modern, triangular wooden structure with a glass entrance, surrounded by lush greenery.

20. Santo Cielo by Casa Santo Domingo

Santo Cielo by Casa Santo Domingo
3.5 star property
0.9 km from Santa Ana
9.4 out of 10, Exceptional, (573 reviews)
"Great place and staff"
United States
Ricardo
The price is ₩284,688
₩363,671 total
includes taxes & fees
Oct 6 - Oct 7
Santo Cielo by Casa Santo Domingo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Hotel Las Americas

Hotel Las Americas

10/10 Excellent
"Very conveniente place, very close from the airport and the staff members are very helpfull."
gilberto 1-night trip
Posted 7 hours ago
Hotel Las Americas

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on our traveler data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.