Find hotels in Santa Ana, Antigua Guatemala

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Ana hotels

Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.8 out of 10, Excellent, (25 reviews)
"This place has two parts, the hotel and a hostel, I stayed in the private room of the hostel part, it wasn’t very good, but the whole place is very nice, like an oasis with a lot of plants, the hotel Part would be very nice."
United States
SUSAN
The price is ₩56,835
₩69,339 total
includes taxes & fees
Jun 2 - Jun 3
Hostal Casa Buho

Casa Buho B&B

Casa Buho B&B
3.0 star property
Santa Ana
9.2 out of 10, Wonderful, (52 reviews)
"Beautiful hotel with clean rooms and friendly staff. The only downsides are the distance to the center (a 30-minute walk) and the chickens and peacocks screaming early in the morning"
United States
Patrick
The price is ₩76,259
₩93,036 total
includes taxes & fees
Jun 2 - Jun 3
Casa Buho B&B

Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"It was a very nice house. My family and I loved it so much."
United States
Gregory Israel
The price is ₩191,513
₩233,646 total
includes taxes & fees
May 20 - May 21
Villas Santa Ana-Ricardo

La guarida del caudillo

La guarida del caudillo
1.0 star property
Santa Ana
The price is ₩41,447
₩50,565 total
includes taxes & fees
Jun 19 - Jun 20
La guarida del caudillo

Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
6.0 out of 10, (1 review)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is ₩22,026
₩45,090 total
includes taxes & fees
May 20 - May 21
Castillo De Los Gigantes

Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center
4.5 star property
20.1 km from Santa Ana
9.2 out of 10, Wonderful, (1,008 reviews)
"Great food, rooms are clean!!"
United States
Rossana
The price is ₩169,127
₩206,335 total
includes taxes & fees
May 24 - May 25
Tikal Futura Hotel & Convention Center

In & Out Hotel

In & Out Hotel
3.0 star property
20.9 km from Santa Ana
8.6 out of 10, Excellent, (865 reviews)
"We love staying atbthe In and Out, rooms have AC, very clean, great breakfast and a very reasonable price."
United States
Julian
The price is ₩72,797
₩88,813 total
includes taxes & fees
May 25 - May 26
In & Out Hotel

Hotel Las Gardenias

Hotel Las Gardenias
2.0 star property
24.1 km from Santa Ana
The price is ₩59,970
₩73,163 total
includes taxes & fees
May 20 - May 21
Hotel Las Gardenias

Barceló Guatemala City

Barceló Guatemala City
4.5 star property
22.7 km from Santa Ana
9.2 out of 10, Wonderful, (3,320 reviews)
"great hotel, good location."
United States
emma
The price is ₩177,700
₩216,794 total
includes taxes & fees
Jun 14 - Jun 15
Barceló Guatemala City

Casa Aurora

Casa Aurora
3.0 star property
20.9 km from Santa Ana
9.0 out of 10, Wonderful, (189 reviews)
"Breakfast was great, very frendly staff."
United States
Marlon
The price is ₩68,576
₩83,663 total
includes taxes & fees
May 27 - May 28
Casa Aurora

Aurora Express

Aurora Express
3.5 star property
20.7 km from Santa Ana
9.0 out of 10, Wonderful, (665 reviews)
"Love this place"
United States
Erick
The price is ₩79,294
₩96,738 total
includes taxes & fees
Jun 17 - Jun 18
Aurora Express

AC Hotel by Marriott Guatemala City

AC Hotel by Marriott Guatemala City
4.0 star property
26.4 km from Santa Ana
8.6 out of 10, Excellent, (1,004 reviews)
"Best Hotel in Guatemala City! The food was very delicious and rooms are very clean."
United States
Manuel
The price is ₩192,633
₩235,012 total
includes taxes & fees
May 23 - May 24
AC Hotel by Marriott Guatemala City

Suites Terraza Imperial

Suites Terraza Imperial
3.0 star property
22.5 km from Santa Ana
9.0 out of 10, Wonderful, (336 reviews)
"Was a nice place to stay easy and convenient clean "
Canada
Dallas
The price is ₩88,850
₩117,506 total
includes taxes & fees
May 20 - May 21
Suites Terraza Imperial

La Inmaculada Hotel

La Inmaculada Hotel
3.5 star property
23.7 km from Santa Ana
9.2 out of 10, Wonderful, (643 reviews)
"Staff was very friendly and helpful. Airport Shuttle was very convenient"
United States
Orlando
The price is ₩145,218
₩177,166 total
includes taxes & fees
May 23 - May 24
La Inmaculada Hotel

Hotel Don Felipe Airport

Hotel Don Felipe Airport
2.0 star property
20.8 km from Santa Ana
8.4 out of 10, Very Good, (47 reviews)
"Had a great experience, staff was top notch, accommodating, and the lovely lady who works the evening shift deserves a huge raise!"
United States
Laura
The price is ₩49,652
₩60,583 total
includes taxes & fees
Jun 18 - Jun 19
Hotel Don Felipe Airport

Inari Guatemala

Inari Guatemala
3.0 star property
20.8 km from Santa Ana
9.0 out of 10, Wonderful, (100 reviews)
"This was an amazing place "
United States
Sherry
The price is ₩78,017
₩95,181 total
includes taxes & fees
May 21 - May 22
Inari Guatemala

L Aurora Inn

L Aurora Inn
3.0 star property
21 km from Santa Ana
9.0 out of 10, Wonderful, (140 reviews)
"Comfortable room, very close to the airport, and a nice breakfast"
United Kingdom
ANITA
The price is ₩125,049
₩152,560 total
includes taxes & fees
Jun 14 - Jun 15
L Aurora Inn

Villas Santander - Deluxe Stay

Villas Santander - Deluxe Stay
3.0 star property
24.7 km from Santa Ana
7.4 out of 10, Good, (249 reviews)
"Parking is easy "
United States
Walter
The price is ₩52,912
₩64,552 total
includes taxes & fees
May 20 - May 21
Villas Santander - Deluxe Stay

Hotel Vista Quince

Hotel Vista Quince
5.0 star property
25.5 km from Santa Ana
8.6 out of 10, Excellent, (267 reviews)
"Great place"
United States
CHRISTOPHER
The price is ₩188,153
₩229,546 total
includes taxes & fees
May 22 - May 23
Hotel Vista Quince

Best Western Plus Hotel Stofella

Best Western Plus Hotel Stofella
4.0 star property
23.3 km from Santa Ana
8.8 out of 10, Excellent, (1,017 reviews)
"Great place to stay"
United States
Miriam
The price is ₩136,964
₩167,098 total
includes taxes & fees
May 29 - May 30
Best Western Plus Hotel Stofella
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on our traveler data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 14 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.