The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls for 2026

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A spacious living room with a fireplace, large windows, and modern furniture.

A spacious lobby with modern seating, large windows, and a city view.

A hotel room with a large bed, wooden wardrobe, a TV, and a kitchenette area.

1. Highpoint Hotel

University Heights, 0.2 km from Sioux Empire Medical Museum

Randell J

₩185,237

₩205,913 total

includes taxes & fees

Oct 11 - Oct 12

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

An indoor swimming pool with a water slide, a large umbrella structure, and a frog-shaped water feature.

A spacious lobby with a central seating area, a staircase, and a fireplace.

2. Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

Claudine

₩180,908

₩217,047 total

includes taxes & fees

Oct 11 - Oct 12

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A bar area with high stools and tables, a bar counter with bottles, and a seating area with cushioned chairs.

A modern hotel room with a large bed, a decorative wall, a nightstand, a chair, and a large window with a city view.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

3. Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Frank

₩202,095

₩224,406 total

includes taxes & fees

Oct 4 - Oct 5

A patio with wicker chairs and a round table with a fire pit.

An indoor swimming pool with two lanes, safety railings, and lounge chairs.

A modern hotel room with a dining area, a sofa, a desk, and a chair.

A modern hotel room with a bed, a sofa, a small table, a TV, and a bathroom visible through an open door.

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

Ross

₩165,440

₩184,195 total

includes taxes & fees

Oct 4 - Oct 5

A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

A hotel room with a desk, two beds, a TV, and a window with a striped blind.

A swimming pool with clear water, surrounded by a tiled deck and seating areas.

A hotel lobby with a bar area, seating, and a television.

5. Hampton Inn Sioux Falls

Mall District, 3.1 km from Sioux Empire Medical Museum

Derrick

₩145,630

₩162,463 total

includes taxes & fees

Oct 18 - Oct 19

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A modern building with a sign reading "THE STEEL DISTRICT" and a covered walkway.

A modern kitchen with a central island, bar stools, pendant lights, and a view through large glass doors.

6. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

Marius

₩276,474

₩314,125 total

includes taxes & fees

Oct 4 - Oct 5

A covered outdoor area with a wooden railing, chairs, and tables.

A traditional room with wooden paneling, a sofa, armchairs, a patterned rug, and stained glass windows.

A two-story house with a front porch, a central entrance, and a small garden area.

A kitchen with white cabinets, granite countertops, stainless steel appliances, and a chandelier.

7. Historic Victorian Inn

Cathedral, 1.5 km from Sioux Empire Medical Museum

Jackie

₩145,525

₩181,846 total

includes taxes & fees

Oct 6 - Oct 7

A long communal dining table with chairs, a bar area with shelves of bottles, and a brick wall with a mirror.

A multi-story hotel with a modern design, featuring balconies on each floor and a visible restaurant named "CRAVE" at the ground level.

A multi-story hotel with a modern design, featuring a central courtyard and a river in front.

A modern lobby with seating areas, a large pillar, and a wall mural.

8. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

Todd

₩171,857

₩199,359 total

includes taxes & fees

Oct 25 - Oct 26

A buffet with labeled containers of omelets and other dishes.

A Holiday Inn Express & Suites building with a brick facade, illuminated signage, and a covered entrance area.

A hotel room with a large bed, a small desk, a chair, a kitchenette, and a nightstand with a lamp.

A reception area with a glass door entrance, a reception desk, and a computer station.

9. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

John

₩142,177

₩158,678 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A hotel room with a bed, a sofa, a chair, a desk, and a large window with a city view.

A modern hotel lobby with a bar area, seating arrangements, and a view of the lobby.

A large conference room with a central stage, round tables with white chairs, and a patterned carpet.

10. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Rachael

₩148,948

₩186,414 total

includes taxes & fees

Oct 11 - Oct 12

A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

A multi-level hotel lobby with a central courtyard, featuring a patterned floor, multiple levels of balconies, and a rock formation.

An indoor swimming pool with clear windows, chairs, and a tiled floor.

A multi-level hotel lobby with a central atrium, multiple floors, and a variety of seating areas.

11. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Joan

₩142,719

₩159,272 total

includes taxes & fees

Oct 11 - Oct 12

A multi-story hotel with a flat roof, a landscaped area with a water feature, and a bridge connecting to another building.

A hotel room with a large bed, a desk with a computer, a chair, a lamp, and three framed pictures on the wall.

A restaurant with a long wooden table, multiple chairs, a bar area, and a stone wall.

A swimming pool with lounge chairs and umbrellas, a view of the outside, and a sign indicating the hotel name.

12. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

Hayley

₩128,907

₩144,119 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with two beds, a desk with a computer, a television, and a couch.

A sign for Center Inn with a parking lot and buildings in the background.

A hotel reception area with a Christmas tree, a clock, and a sign indicating a non-smoking policy.

A restaurant interior with wooden tables and chairs, a 'Welcome' sign, decorative wall art, a TV, and a window view.

13. The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

Marissa

₩129,093

₩144,324 total

includes taxes & fees

Oct 2 - Oct 3

An indoor pool area with a slide, seating, and tropical decor.

A modern restaurant with a central bar, red cushioned chairs, and a 'TEAM ROOM' sign.

A living room with a fireplace, a television, and a dining area with a table and chairs.

A lobby with a stone fire feature, seating area, and a reception desk.

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Sami

₩84,020

₩94,877 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A small, cozy room with a sofa, two armchairs, a coffee table, and a desk with a lamp. There are two framed pictures on the wall.

A small cafe with a 'Good Morning' sign, a coffee machine, a microwave, and a refrigerator.

15. Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

Darrel

₩110,695

₩124,154 total

includes taxes & fees

Sep 29 - Sep 30

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

A wooden door with a glass panel, leading to a brick-paved entrance.

A dining room with a wooden table, six chairs, and a chandelier.

16. Historic Twin Tudors Inn

1.4 km from Sioux Empire Medical Museum

Anonymous traveler

₩344,137

₩390,992 total

includes taxes & fees

Oct 4 - Oct 5

17. Sioux Falls Inn

Northwest Sioux Falls, 3.1 km from Sioux Empire Medical Museum

Stephanie

₩74,189

₩84,093 total

includes taxes & fees

Sep 29 - Sep 30

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

A hallway with a wooden floor, a small black desk with a mirror, and a door with a glass panel.

A laundry room with multiple white washers and dryers, wooden flooring, and a door on the left.

Two vending machines in a hallway with a sign that reads "VENDORS".

18. WoodSpring Suites Sioux Falls

2.8 km from Sioux Empire Medical Museum

Catherine

₩106,972

₩120,057 total

includes taxes & fees

Sep 29 - Sep 30

A reception area with a counter, a food mart sign, and a security camera.

A hotel room with two beds, a desk, a chair, and a TV.

A Ramada hotel with a covered entrance, parking lot, and handicap-accessible parking spaces.

A breakfast bar with seating, a microwave, toaster, and a coffee maker.

19. Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

Tiffany

₩78,265

₩88,565 total

includes taxes & fees

Oct 11 - Oct 12

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A conference room with a long table, chairs, water bottles, a flat-screen TV, and a window with curtains.

A compact hotel room with a kitchenette, a bed, a TV, and a seating area.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a dining area with a table and chairs.

20. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 5.2 km from Sioux Empire Medical Museum

Bailey

₩174,675

₩194,336 total

includes taxes & fees

Oct 18 - Oct 19

View all properties

Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Highpoint Hotel	9.8 Exceptional 337 reviews	View
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,226 reviews	View
Hotel On Phillips	9.6 Exceptional 1,597 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 674 reviews	View
Hampton Inn Sioux Falls	9.4 Exceptional 1,005 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"Staff were great. Lobby was amazing"

Baymont by Wyndham Sioux Falls

8/10 Good

"Staff was very helpful."

Highpoint Hotel

10/10 Excellent

"Beautiful room and views"

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

10/10 Excellent

"The rooms were amazing!! It’s like a mini apartment!!! Mini kitchen and very comfortable beds!!! Best sleep I’ve ever had in a hotel!! Would definitely stay here again if I’m in the area!!"

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

8/10 Good

"1st level very noisy by the door. Slammed all night with each person going in and out."

Hilton Garden Inn Sioux Falls Downtown

10/10 Excellent

"Had a great stay"

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

See properties

Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time browsing the exhibits at Center for Western Studies in Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time exploring the galleries in Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can enjoy a show at Washington Pavilion of Arts and Science on your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time browsing the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, check out the 136 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.

How many hotels will I be able to find close to Sioux Empire Medical Museum?

Expedia has 136 hotels and other accommodations within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best options available near Sioux Empire Medical Museum.

Where can I learn more about changing or cancelling my trip in the area near Sioux Empire Medical Museum?

For more details about changing or cancelling your stay near Sioux Empire Medical Museum, go to https://www.expedia.com/service/.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum, and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Find hotels near Sioux Empire Medical Museum, Sioux Falls from ₩84,093

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Clubhouse Hotel Suites Sioux Falls

3. Hotel On Phillips

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

5. Hampton Inn Sioux Falls

6. Canopy By Hilton Sioux Falls Downtown

7. Historic Victorian Inn

8. Hilton Garden Inn Sioux Falls Downtown

9. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

10. Holiday Inn Sioux Falls-City Centre by IHG

11. Sheraton Sioux Falls Hotel & Convention Center

12. Country Inn & Suites by Radisson, Sioux Falls

13. The Center Inn

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

15. Valley Inn

16. Historic Twin Tudors Inn

17. Sioux Falls Inn

18. WoodSpring Suites Sioux Falls

19. Ramada by Wyndham Sioux Falls

20. Staybridge Suites Sioux Falls Southwest by IHG

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Clubhouse Hotel Suites Sioux Falls

Baymont by Wyndham Sioux Falls

Highpoint Hotel

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Hilton Garden Inn Sioux Falls Downtown

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions