The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls for 2026

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A hotel room with a large bed, wooden wardrobe, a TV, and a kitchenette area.

A spacious lobby with modern seating, large windows, and a city view.

A spacious living room with a fireplace, large windows, and modern furniture.

1. Highpoint Hotel

University Heights, 0.2 km from Sioux Empire Medical Museum

Randell J

₩162,628

₩181,080 total

includes taxes & fees

Oct 18 - Oct 19

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

A spacious lobby with multiple seating areas, a fireplace, and large windows.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

A spacious lobby with a central seating area, a staircase, and a fireplace.

2. Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

Jordyn

₩178,827

₩214,552 total

includes taxes & fees

Oct 25 - Oct 26

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A bar area with high stools and tables, a bar counter with bottles, and a seating area with cushioned chairs.

A modern hotel room with a desk, chair, and bed. It features a large window with a city view, a flat-screen TV, and a wooden wardrobe.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

3. Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Judy

₩209,810

₩232,846 total

includes taxes & fees

Oct 11 - Oct 12

A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

A swimming pool with clear water, surrounded by a tiled deck and seating areas.

A snack and beverage display area with various snacks and drinks.

A hotel lobby with a bar area, seating, and a television.

4. Hampton Inn Sioux Falls

Mall District, 3.1 km from Sioux Empire Medical Museum

Mary

₩143,782

₩160,406 total

includes taxes & fees

Nov 1 - Nov 2

A patio with wicker chairs and a round table with a fire pit.

A modern hotel room with a bed, a sofa, a small table, a TV, and a bathroom visible through an open door.

A breakfast area with a long table, orange chairs, and various breakfast items displayed on shelves.

A modern hotel room with a dining area, a sofa, a desk, and a chair.

5. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

Ross

₩164,079

₩182,677 total

includes taxes & fees

Oct 18 - Oct 19

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A modern dining area with a large marble table, comfortable chairs, a built-in fireplace, and a large TV mounted on a dark wall.

A modern building with a sign reading "THE STEEL DISTRICT" and a covered walkway.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

6. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

Marnie

₩203,653

₩234,114 total

includes taxes & fees

Nov 1 - Nov 2

A buffet with labeled containers of omelets and other dishes.

A hotel room with a large bed, a small desk, a chair, a kitchenette, and a nightstand with a lamp.

A Holiday Inn Express & Suites building with a brick facade, illuminated signage, and a covered entrance area.

A reception area with a glass door entrance, a reception desk, and a computer station.

7. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

Hagel

₩140,543

₩156,853 total

includes taxes & fees

Oct 18 - Oct 19

A long communal dining table with chairs, a bar area with shelves of bottles, and a brick wall with a mirror.

A multi-story hotel with a modern design, featuring a central courtyard and a river in front.

A spacious hallway with a patterned carpet, large windows, and seating areas.

A multi-story hotel with a modern design, featuring balconies on each floor and a visible restaurant named "CRAVE" at the ground level.

8. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

Samuel

₩164,917

₩191,623 total

includes taxes & fees

Nov 1 - Nov 2

A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

An indoor swimming pool with clear windows, chairs, and a tiled floor.

A hotel room with a bed, a sofa, a TV, and a desk.

A multi-level hotel lobby with a central atrium, multiple floors, and a variety of seating areas.

9. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Joan

₩152,455

₩169,921 total

includes taxes & fees

Oct 25 - Oct 26

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A modern hotel lobby with a bar area, seating arrangements, and a view of the lobby.

A large conference room with a central stage, round tables with white chairs, and a patterned carpet.

A hotel room with a bed, a sofa, a chair, a desk, and a large window with a city view.

10. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Stacey

₩147,565

₩184,686 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with two beds, a desk with a computer, a television, and a couch.

A restaurant interior with wooden tables and chairs, a 'Welcome' sign, decorative wall art, a TV, and a window view.

A sign for Center Inn with a parking lot and buildings in the background.

A black leather chair, a floor lamp, and a window with a view of parked cars.

11. The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

Marissa

₩127,608

₩142,663 total

includes taxes & fees

Oct 9 - Oct 10

A multi-story hotel with a flat roof, a landscaped area with a water feature, and a bridge connecting to another building.

A restaurant with a long wooden table, multiple chairs, a bar area, and a stone wall.

A hotel room with a wooden table, a laptop, a telephone, a glass of orange juice, a lamp, and a chair.

A hotel room with a large bed, a desk with a computer, a chair, a lamp, and three framed pictures on the wall.

12. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

Hayley

₩122,071

₩136,589 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A small cafe with a 'Good Morning' sign, a coffee machine, a microwave, and a refrigerator.

A building with a sign that reads "Valley Inn" and another sign indicating a motel.

13. Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

Robert

₩100,388

₩112,803 total

includes taxes & fees

Oct 21 - Oct 22

An indoor pool area with a slide, seating, and tropical decor.

A restaurant with booths and tables, a TV screen, and a view of the outdoors.

A modern restaurant with a central bar, red cushioned chairs, and a 'TEAM ROOM' sign.

A lobby with a stone fire feature, seating area, and a reception desk.

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Sami

₩83,054

₩93,787 total

includes taxes & fees

Nov 1 - Nov 2

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A dining room with a wooden table, six chairs, and a chandelier.

A two-story house with a steeply pitched roof, a front porch, and a brick entrance.

A wooden door with a glass panel, leading to a brick-paved entrance.

15. Historic Twin Tudors Inn

1.4 km from Sioux Empire Medical Museum

Anonymous traveler

₩340,943

₩387,363 total

includes taxes & fees

Oct 13 - Oct 14

16. Sioux Falls Inn

Northwest Sioux Falls, 3.1 km from Sioux Empire Medical Museum

Randy

₩73,336

₩83,127 total

includes taxes & fees

Oct 8 - Oct 9

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

Two vending machines in a hallway with a sign that reads "VENDORS".

A laundry room with multiple white washers and dryers, wooden flooring, and a door on the left.

A hallway with a wooden floor, a small black desk with a mirror, and a door with a glass panel.

17. WoodSpring Suites Sioux Falls

2.8 km from Sioux Empire Medical Museum

Catherine

₩105,742

₩118,675 total

includes taxes & fees

Oct 12 - Oct 13

A reception area with a counter, a food mart sign, and a security camera.

A swimming pool with a tiled floor, a poolside table, and chairs.

A Ramada hotel with a covered entrance, parking lot, and handicap-accessible parking spaces.

A breakfast bar with seating, a microwave, toaster, and a coffee maker.

18. Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

Tiffany

₩72,814

₩82,555 total

includes taxes & fees

Nov 1 - Nov 2

A swimming pool with clear blue water, surrounded by a tiled deck and a seating area with chairs and tables.

A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a clear view of the building's facade.

An outdoor patio area with tables and chairs, string lights, and a view of the city skyline.

A modern hotel room with a kitchenette, a sofa, a dining table, a small round table, a bed, and a view of the outdoors.

19. Comfort Inn & Suites at Sanford Sports Complex

Northwest Sioux Falls, 6 km from Sioux Empire Medical Museum

Girhard

₩137,464

₩153,480 total

includes taxes & fees

Oct 18 - Oct 19

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A modern hotel room with a kitchenette, a bed, a sofa, a dining area, and a view of the outdoors.

A gym with exercise equipment, a mirror, a clock, and a television.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a dining area with a table and chairs.

20. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 5.2 km from Sioux Empire Medical Museum

Bailey

₩165,974

₩184,753 total

includes taxes & fees

Nov 1 - Nov 2

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Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Highpoint Hotel	9.8 Exceptional 360 reviews	View
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,229 reviews	View
Hotel On Phillips	9.6 Exceptional 1,612 reviews	View
Hampton Inn Sioux Falls	9.4 Exceptional 1,007 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 676 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Hotel On Phillips

10/10 Excellent

"Book it here! Such a great hotel! The shuttle is great even just for a few blocks if you don’t want to walk anymore!"

Holiday Inn Sioux Falls-City Centre by IHG

10/10 Excellent

"We had a good one night stay for a concert at the Denny Sanford. Easy to find, easy to park."

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time browsing the exhibits at Center for Western Studies in Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time exploring the galleries in Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can enjoy a show at Washington Pavilion of Arts and Science on your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time browsing the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, check out the 136 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.

How many hotels will I be able to find close to Sioux Empire Medical Museum?

Expedia has 136 hotels and other accommodations within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best options available near Sioux Empire Medical Museum.

Where can I learn more about changing or cancelling my trip in the area near Sioux Empire Medical Museum?

For more details about changing or cancelling your stay near Sioux Empire Medical Museum, go to https://www.expedia.com/service/.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum, and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Find hotels near Sioux Empire Medical Museum, Sioux Falls from ₩82,555

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Clubhouse Hotel Suites Sioux Falls

3. Hotel On Phillips

4. Hampton Inn Sioux Falls

5. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

6. Canopy By Hilton Sioux Falls Downtown

7. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

8. Hilton Garden Inn Sioux Falls Downtown

9. Sheraton Sioux Falls Hotel & Convention Center

10. Holiday Inn Sioux Falls-City Centre by IHG

11. The Center Inn

12. Country Inn & Suites by Radisson, Sioux Falls

13. Valley Inn

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

15. Historic Twin Tudors Inn

16. Sioux Falls Inn

17. WoodSpring Suites Sioux Falls

18. Ramada by Wyndham Sioux Falls

19. Comfort Inn & Suites at Sanford Sports Complex

20. Staybridge Suites Sioux Falls Southwest by IHG

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Hotel On Phillips

Holiday Inn Sioux Falls-City Centre by IHG

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions