Southern Illinois Vacations
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ₩1,660,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Where to stay in Southern Illinois
Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois
Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
Uptown
If you're spending some time in Uptown, Kruta Bakery and World's Largest Catsup Bottle are top sights worth seeing.
Alorton
Alorton is well-liked for its restaurants. If you'd like to do some sightseeing in the greater East St. Louis area, you might plan a trip to Arsenal BG Ballpark or Gateway Arch.
Mulberry Hills
While Mulberry Hills isn't home to many top sights, Gateway Conference Center and Stonewolf Golf Course are some notable places to visit nearby.
Historic Downtown Collinsville
While Historic Downtown Collinsville isn't home to many top sights, Gateway Conference Center and Splash City Family Waterpark are some notable places to visit nearby.
Find the Best Southern Illinois Vacation Packages
Southern Illinois Hotel Deals
Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
₩121,139
₩136,864 total
Sep 20 - Sep 21
includes taxes & fees
Drury Plaza Hotel Mt. Vernon
145 North 44th Street Mount Vernon IL
Fully refundableReserve now, pay when you stay
₩149,408
₩168,505 total
Sep 13 - Sep 14
includes taxes & fees
9.8/10 Exceptional! (1,804 reviews)
"Excellent"
Reviewed on Sep 6, 2026
Quality Inn O'Fallon - St. Louis - Shiloh
1409 W US 50 O'Fallon IL
Fully refundable
₩83,595
₩96,117 total
Sep 13 - Sep 14
includes taxes & fees
7.4/10 Good! (1,008 reviews)
"Location great"
Reviewed on Sep 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Southern Illinois attractions
Garden of the Gods Recreation Area
9.8/10 (63 reviews)
See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.
World Wide Technology Raceway
9.0/10 (2 reviews)
Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
O'Fallon Family Sports Park
8.6/10 (137 reviews)
This sports complex features premium turf fields, splash pads, and fishing ponds in a family-friendly setting. Watch tournaments or enjoy the scenic walking trail that winds around natural areas.
Harrah's Metropolis
8.0/10 (310 reviews)
This riverside casino offers over 600 slot machines and 17 table games along the scenic Ohio River. Join the rewards program to maximize your experience while enjoying Southern classics at the on-site restaurants.
Frequently asked questions
How much does a Southern Illinois vacation package cost?
From just , you can tailor make your Southern Illinois vacation package. Simply bundle hotels, flights and car rentals and be rewarded with discounts.
How do I get a cheap travel package to Southern Illinois?
Bundle your flights and hotels with Expedia to save big on your next big adventure. With over 550 airlines and 1,000,000 hotels globally, your Southern Illinois vacation package can be tailored exactly to suit your budget. With all that extra money, why not throw in one or more awesome activities and tours? It's an easy way to unlock even more discounts. Your dream getaway to Southern Illinois is much closer than you thought!
What are the top hotels in Southern Illinois?
Take a look at Super 8 by Wyndham Carbondale and Best Western Saluki Inn. They're top picks for lots of travelers to Carbondale. If Marion is on your travel itinerary, Super 8 by Wyndham Marion and Quality Inn And Suites are a couple of popular options.
How far in advance should I book my Southern Illinois vacation?
Reward yourself with the widest variety at the lowest prices by booking your vacation to Southern Illinois early. Air carriers usually sell flight tickets around 12 months before departure, so reserve your spot ASAP. That said, Expedia is dedicated to giving you the best bargains around, so it's never a bad time to book your dream vacation!
What does an Expedia Southern Illinois travel package include?
That depends on what sort of trip you're contemplating. Southern Illinois vacation deals can include flights, hotels and car rentals. You can mix and match to create the travel package that suits you. You can also add on experiences and activities after you've booked to get even bigger discounts.
What should I know before booking a Southern Illinois travel package?
You'll score excellent savings when you combine your flights, hotels and rental cars into a package. Not only that, booking everything in one spot will make your trip planning easier. So why waste your money or time? Whether you're organizing a ritzy city getaway or a low-cost family road trip, explore our vacation packages today.
Can I choose my airline with a Southern Illinois Expedia vacation package?
You can, and with more than 550 airlines to pick from across the globe, you're not short on choice. Browse the available options and see which airline fits your needs and budget.
If I'm not able to travel, can I cancel my Southern Illinois vacation package?
You can cancel your Southern Illinois booking if your plans have changed. Whether you'll be charged a fee or not depends on your airline, hotel or car rental company. It may be possible to cancel or change for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
