Photo by RVLuckyorWhat

Find hotels in Upstate South Carolina, SC from ₩99,819

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 31 - Jan 1
Tomorrow
Jan 1 - Jan 2
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Upstate South Carolina hotels

Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Greenville Airport

Comfort Suites Greenville Airport

Comfort Suites Greenville Airport
2.5 star property
Greenville
9.2 out of 10, Wonderful, (1009)
"We stayed here based on proximity to GSP airport. It was clean, parking lot was well lit, room was spacious and comfortable. Would stay here again."
United States
Lawrence
The price is ₩141,861
₩160,303 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Comfort Suites Greenville Airport
Free daily full breakfast
Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG
2.5 star property
Gaffney
8.8 out of 10, Excellent, (427)
"Great place to stay"
United States
Timothy
The price is ₩118,663
₩129,345 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Holiday Inn Express Gaffney by IHG
Exterior
DoubleTree by Hilton Greenville Woodruff Road

DoubleTree by Hilton Greenville Woodruff Road

DoubleTree by Hilton Greenville Woodruff Road
3.0 star property
Greenville
9.4 out of 10, Exceptional, (1002)
"Clean modern comfortable convenient location great cookie "
United States
Jimmy
The price is ₩168,917
₩185,808 total
includes taxes & fees
Jan 6 - Jan 7, 2026
DoubleTree by Hilton Greenville Woodruff Road
Free daily continental breakfast
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites
2.5 star property
Greenville
9.0 out of 10, Wonderful, (1427)
"The room was clean, staffs were welcoming and the breakfast food was good. "
United States
Ngan
The price is ₩109,385
₩120,323 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Best Western Plus Greenville I-385 Inn & Suites
Reception
Hampton Inn & Suites Greenville Airport, SC

Hampton Inn & Suites Greenville Airport, SC

Hampton Inn & Suites Greenville Airport, SC
2.5 star property
Greenville
9.2 out of 10, Wonderful, (1000)
"Very clean room and a Great Staff "
United States
Myron
The price is ₩140,252
₩154,277 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Hampton Inn & Suites Greenville Airport, SC
Exterior
Hampton Inn Anderson/ Alliance Business Park

Hampton Inn Anderson/ Alliance Business Park

Hampton Inn Anderson/ Alliance Business Park
2.5 star property
Anderson
9.2 out of 10, Wonderful, (810)
"Staff, Just a Nice Hotel"
United States
Christopher
The price is ₩162,297
₩180,150 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Hampton Inn Anderson/ Alliance Business Park
Lounge
SpringHill Suites by Marriott Greenville Downtown

SpringHill Suites by Marriott Greenville Downtown

SpringHill Suites by Marriott Greenville Downtown
2.5 star property
Greenville Downtown
9.6 out of 10, Exceptional, (1000)
"Great spot and beautiful hotel!"
United States
Lisa
The price is ₩176,211
₩193,831 total
includes taxes & fees
Jan 18 - Jan 19, 2026
SpringHill Suites by Marriott Greenville Downtown
Coffee shop
Four Points by Sheraton Spartanburg

Four Points by Sheraton Spartanburg

Four Points by Sheraton Spartanburg
3.0 star property
Spartanburg
9.4 out of 10, Exceptional, (439)
"Friendly staff, clean rooms, excellent food! "
United States
Ashley
The price is ₩171,316
₩190,161 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Four Points by Sheraton Spartanburg
Indoor pool, outdoor pool
Drury Inn & Suites Greenville

Drury Inn & Suites Greenville

Drury Inn & Suites Greenville
3.0 star property
Greenville
9.4 out of 10, Exceptional, (1001)
"We had a great time we will be back "
United States
Tara
The price is ₩154,391
₩169,832 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Drury Inn & Suites Greenville
Free daily on-the-go breakfast
Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville
2.5 star property
Greer
8.6 out of 10, Excellent, (736)
"Staff was incredibly friendly and helpful!"
United States
Sarah
The price is ₩134,749
₩146,877 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Comfort Inn & Suites Greer - Greenville
Aerial view
Lakeside Lodge Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1000)
"Great place to stay. "
United States
Gene
The price is ₩155,835
₩193,450 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Lakeside Lodge Clemson
Desk, laptop workspace, blackout drapes, iron/ironing board
Hyatt Place Greenville Downtown

Hyatt Place Greenville Downtown

Hyatt Place Greenville Downtown
3.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1000)
"I have stayed here several times and it is always clean and comfortable, also the staff is very nice. "
United States
Melissa
The price is ₩174,421
₩191,862 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hyatt Place Greenville Downtown
Free daily full breakfast
La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood
3.0 star property
Greenville
7.4 out of 10, Good, (1131)
"Kind staff, clean room, tasty continental breakfast!"
United States
Karen
The price is ₩106,245
₩116,869 total
includes taxes & fees
Jan 4 - Jan 5, 2026
La Quinta Inn & Suites by Wyndham Greenville Haywood
Terrace/patio
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center
3.5 star property
Greenville
9.0 out of 10, Wonderful, (1000)
"Great stay. "
United States
kurt
The price is ₩140,681
₩154,749 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Embassy Suites Greenville Golf Resort & Conference Center
Outdoor pool
Hampton Inn Greer Greenville, SC

Hampton Inn Greer Greenville, SC

Hampton Inn Greer Greenville, SC
2.5 star property
Greer
9.6 out of 10, Exceptional, (416)
"Very nice hotel! Clean! "
United States
Eric
The price is ₩198,726
₩216,611 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Hampton Inn Greer Greenville, SC
Restaurant
Hampton Inn & Suites Greenville-Downtown-RiverPlace

Hampton Inn & Suites Greenville-Downtown-RiverPlace

Hampton Inn & Suites Greenville-Downtown-RiverPlace
2.5 star property
Greenville Downtown
9.4 out of 10, Exceptional, (1002)
"Clean rooms, great location "
United States
Justin
The price is ₩190,791
₩215,594 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Hampton Inn & Suites Greenville-Downtown-RiverPlace
BBQ/picnic area
Hilton Garden Inn Greenville

Hilton Garden Inn Greenville

Hilton Garden Inn Greenville
3.0 star property
Greenville
9.0 out of 10, Wonderful, (1000)
"Great check in, room was perfect "
United States
Jonathan
The price is ₩128,674
₩145,789 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Hilton Garden Inn Greenville
Exterior
Aloft Greenville Downtown

Aloft Greenville Downtown

Aloft Greenville Downtown
3.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1001)
"Always a great place to stay. "
United States
Daniel
The price is ₩176,211
₩193,831 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Aloft Greenville Downtown
Fitness facility
Best Western Greenville Airport Inn

Best Western Greenville Airport Inn

Best Western Greenville Airport Inn
2.5 star property
Greenville
7.8 out of 10, Good, (1004)
"Good hotel "
United States
magadan
The price is ₩116,819
₩128,501 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Best Western Greenville Airport Inn
Property amenity
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
8.2 out of 10, Very Good, (1000)
"Clean room and staff were great’"
United States
Audrey
The price is ₩132,460
₩147,031 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Best Western Plus Clemson Hotel & Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Great weekend hotel deals in Upstate South Carolina, SC

Showing deals for:Jan 9 - Jan 11

Image gallery for Hotel Domestique

Bar (on property)

Hotel Domestique

4.0 star property
Travelers Rest
9.8/10Exceptional (31 reviews)
Member Price available
Price is ₩421,092
₩926,431 total
includes taxes & fees
Sign in for Member Price
Hotel Domestique
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Southeastern United States attractions

"Clemson University is an American public, coeducational, land-grant and sea-grant research university located in Clemson, South Carolina, United States.More clemson images:"

Clemson University

4.7/5 (738 reviews)
Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.
See properties
Exploring Falls Park on the Reedy in Downtown Greenville, South Carolina during a peaceful afternoon stroll with scenic views

Falls Park on the Reedy

4.7/5 (1,399 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
See properties

Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
The view from Caesars Head after a storm
Photo by Michelle Hendrix
Open Photo by Michelle Hendrix

Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent
"size of room, ac was quite, window shades"
Jack Munch 5-night trip
Posted 1 day ago
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

More cheap stays in Upstate South Carolina

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

1007 George Smith Mill Rd Anderson SC
The price is ₩89,927 per night from Jan 6 to Jan 7
₩89,927
₩99,819 total
Jan 6 - Jan 7, 2026
includes taxes & fees
7.8/10 Good! (1,001 reviews)

Hotels in Upstate South Carolina with star-rating