A bench, a bicycle, and a lake surrounded by trees.

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Go beyond your typical stay in Upstate South Carolina

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Our top choices for Upstate South Carolina hotels

Bed & breakfast

Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Carole

₩137,992 total

includes taxes & fees

Aug 2 - Aug 3

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Shabana

₩168,902 total

includes taxes & fees

Jul 19 - Jul 20

La Quinta by Wyndham Haywood Mall-Near Greenville Downtown

Greenville

Wade

₩125,358 total

includes taxes & fees

Aug 12 - Aug 13

Hampton Inn & Suites Greenville Airport, SC

Greenville

Dianna

₩173,461 total

includes taxes & fees

Jul 27 - Jul 28

Lakeside Lodge Clemson

Seneca

JEFFREY

₩201,714 total

includes taxes & fees

Jul 17 - Jul 18

Holiday Inn Express & Suites Greenwood Mall by IHG

Greenwood

Shannon

₩196,153 total

includes taxes & fees

Aug 2 - Aug 3

Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Premium bedding, desk, laptop workspace, blackout drapes

Comfort Inn & Suites Clemson - University Area

Clemson

Lon

₩177,222 total

includes taxes & fees

Jul 30 - Jul 31

Clarion Greenville Airport Inn

Greenville

Gladys

₩114,295 total

includes taxes & fees

Aug 6 - Aug 7

Drury Inn & Suites Greenville

Greenville

₩201,681 total

includes taxes & fees

Jul 29 - Jul 30

Comfort Inn Greenville - Haywood Mall

Greenville

Janet

₩158,697 total

includes taxes & fees

Jul 20 - Jul 21

Hilton Garden Inn Anderson

Anderson

Gina

₩174,890 total

includes taxes & fees

Aug 7 - Aug 8

Best Western Plus Clemson Hotel & Conference Center

Clemson

Tammy

₩181,440 total

includes taxes & fees

Jul 25 - Jul 26

The Inn at Patrick Square

Clemson

Karyn

₩246,556 total

includes taxes & fees

Jul 19 - Jul 20

Clemson University's James F. Martin Inn

Clemson

Jesse

₩238,281 total

includes taxes & fees

Jul 19 - Jul 20

Inn on the Square, an Ascend Collection Hotel

Uptown Greenwood

LAPORCHIA

₩200,752 total

includes taxes & fees

Aug 16 - Aug 17

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Edna

₩159,063 total

includes taxes & fees

Aug 2 - Aug 3

Hampton Inn Anderson/ Alliance Business Park

Anderson

meagan

₩187,846 total

includes taxes & fees

Jul 24 - Jul 25

Microtel Inn & Suites by Wyndham Anderson/Clemson

Anderson

Johnnie

₩117,652 total

includes taxes & fees

Aug 16 - Aug 17

Fairfield Inn by Marriott Greenville-Spartanburg Airport

Greenville

Brian

₩147,157 total

includes taxes & fees

Jul 30 - Jul 31

Comfort Inn & Suites Greer - Greenville

Greer

ANTHONY

₩171,305 total

includes taxes & fees

Aug 9 - Aug 10

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Vacation Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Love the location. Room was great."

Aparthotel

Coffee/tea maker, full-size fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Lake Access & Boat Slip: Greenwood Cottage!

Greenwood

"Outstanding little cottage for my mom and daughter weekend! Super clean and comfortable. "

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

Serene Cabin w/ Pond & Creek on South Saluda River

Cleveland

"I chose this cabin due to its close proximity to the pretty place chapel. The property was BEAUTIFUL and tucked away. The silence and change of scenery was well needed and felt like we were at home. I honestly don’t have enough good things to say about the host Mr. Steve and his generosity and professionalism!"

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.

See all hotels in Upstate South Carolina

A multi-tiered waterfall cascading over rocks in a forested area.

Top Upstate South Carolina Hotel Reviews

Hyatt Place Greenville Downtown

10/10 Excellent

"Room was very clean. All staff was very friendly. Indoor pool was awesome"

Days Inn by Wyndham Greenville

8/10 Good

"We were on the 2nd floor and had a brand new TV! However we only got about 20 stations as all the others had no signal. Our door did not have a bar to so it never closed by itself and when it did close the dead bolt wouldn't work because the door was not fully flush at the bottom. The ac did not work well and did this high pitch squeal all night so I turned it off only to hear traffic and ambulance and police sirens all night."

Courtyard by Marriott Greenville Haywood Mall

8/10 Good

"The hotel is nice, not the top notch Marriott. Since they don't offer breakfast, they should at least have free coffee in the lounge. It's crazy to pay $10 a night for self-parking in their lot. We didn't see any sign of security around. Room was comfortable."