A modern glass building with a curved facade and a sign reading "The Kentucky Center".

Southern Indiana 4 Stars Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana 4 Star Hotels

Our top choices for Southern Indiana 4-star hotels

4 restaurants; breakfast, lunch, and dinner served

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (4,175 reviews)
"Great hotel & stay!"
United States
Jennifer
The price is ₩240,160
₩282,572 total
includes taxes & fees
Aug 1 - Aug 2
Galt House Hotel Trademark Collection by Wyndham
3 bars/lounges, cocktail bar, lobby lounge

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,992 reviews)
"Beautiful, clean property with many things to do at and around the hotel."
United States
Brittany
The price is ₩237,327
₩279,232 total
includes taxes & fees
Aug 2 - Aug 3
Omni Louisville Hotel
Lobby

Hyatt Regency Louisville

Hyatt Regency Louisville
4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1,002 reviews)
"Beautiful Hotel!"
United States
Joseph
The price is ₩222,122
₩261,348 total
includes taxes & fees
Aug 1 - Aug 2
Hyatt Regency Louisville
Front of property

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,001 reviews)
"Beautiful property, on-site restaurant was delicious. Beds very nice."
United States
nicolle
The price is ₩239,489
₩289,238 total
includes taxes & fees
Aug 9 - Aug 10
21c Museum Hotel Louisville
Reception

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1,298 reviews)
"We liked everything about our stay"
United States
Mark
The price is ₩218,067
₩256,558 total
includes taxes & fees
Jul 31 - Aug 1
Embassy Suites Louisville Downtown
Exterior

Louisville Marriott Downtown

Louisville Marriott Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1,000 reviews)
"Great location and friendly staff. Loved their bar and lobby area."
United States
Bikash
The price is ₩249,999
₩294,148 total
includes taxes & fees
Aug 16 - Aug 17
Louisville Marriott Downtown
Lobby

The Grady

The Grady
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,015 reviews)
"Great place to stay!"
United States
Jennifer
The price is ₩243,289
₩286,253 total
includes taxes & fees
Aug 6 - Aug 7
The Grady
Lobby

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,281 reviews)
"Great people and hotel"
United States
Roland
The price is ₩229,425
₩269,941 total
includes taxes & fees
Aug 4 - Aug 5
The Brown Hotel
Terrace/patio

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (127 reviews)
"Great stay"
United States
Kristen
The price is ₩262,819
₩309,233 total
includes taxes & fees
Aug 16 - Aug 17
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Terrace/patio

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1,111 reviews)
"Great place in NuLu"
United States
Fredrick
The price is ₩201,083
₩236,594 total
includes taxes & fees
Aug 10 - Aug 11
Hotel Genevieve part of JdV by Hyatt
Terrace/patio

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (483 reviews)
"Great hotel and great staff."
United States
Jasmine
The price is ₩300,164
₩353,172 total
includes taxes & fees
Aug 2 - Aug 3
Hotel Distil, Autograph Collection
Lobby

DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville
4.0 star property
Downtown Evansville
8.6 out of 10, Excellent, (1,000 reviews)
"The breakfast at the restaurant was very good. The hotel was very convenient for an event we attended at the Ford Center."
United States
Adrianna
The price is ₩163,207
₩187,685 total
includes taxes & fees
Jul 26 - Jul 27
DoubleTree by Hilton Evansville
Exterior

Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1,000 reviews)
"Room was very clean."
United States
Whitney
The price is ₩243,827
₩286,887 total
includes taxes & fees
Jul 27 - Jul 28
Seelbach Hilton Louisville Downtown
Property entrance

The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B
4.0 star property
New Albany
9.8 out of 10, Exceptional, (709 reviews)
"Lovely property and excellent breakfast"
United States
Jacob
The price is ₩128,290
₩144,968 total
includes taxes & fees
Jul 21 - Jul 22
The Pepin Mansion Historic B&B
Lounge

Stellar Suites

Stellar Suites
4.5 star property
Downtown Louisville
9.6 out of 10, Exceptional, (141 reviews)
"Great location. Lots to do in the area. Room was clean and very nice."
United States
Brad
The price is ₩159,884
₩263,377 total
includes taxes & fees
Jul 20 - Jul 21
Stellar Suites
Exterior

stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville
4.0 star property
Clarksville
9.8 out of 10, Exceptional, (53 reviews)
"Nice place to stay"
United States
Chauntel
The price is ₩251,937
₩284,689 total
includes taxes & fees
Jul 19 - Jul 20
stayAPT Suites Louisville North-Clarksville
Seasonal outdoor pool

CozySuites at Nulu

CozySuites at Nulu
4.0 star property
Downtown Louisville
7.6 out of 10, Good, (32 reviews)
"Wonderful stay - great spot and lots of great dining options and bars nearby "
United States
Roy
The price is ₩110,316
₩301,072 total
includes taxes & fees
Aug 3 - Aug 4
CozySuites at Nulu
32-inch Smart TV with cable channels

The Reserve on Main

The Reserve on Main
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (3 reviews)
"The room was great and clean. Great location. "
United States
De'Carlon
The Reserve on Main
Exterior

Bourbon Barrel Inn Bed & Breakfast

Bourbon Barrel Inn Bed & Breakfast
4.0 star property
Old Louisville
10.0 out of 10, Exceptional, (4 reviews)
"Inn Keepers were wonderful. "
United States
jonathan
Bourbon Barrel Inn Bed & Breakfast
Family House, Multiple Beds | Private kitchen | Fridge, microwave, oven, stovetop

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
4.0 star property
Sellersburg
9.4 out of 10, Exceptional, (10 reviews)
"Very nice house in a nice neighborhood, spacious home environmental, felt more that at home there,"
United States
Tammy
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Southern Indiana

Live music, casinos, and top sights like Holiday World and Splashin' Safari—discover it all in Southern Indiana.

See all hotels in Southern Indiana
A riverboat with multiple decks and passengers, docked near a bridge.

Top Southern Indiana Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Southern Indiana?
Based on reviews by our guests, Galt House Hotel Trademark Collection by Wyndham is among the best 4-star hotels in Southern Indiana. Situated in Louisville, it includes massage services and beauty services. Hyatt Regency Louisville is another sought-after option here. Also with a 4-star rating and offering premium bedding and designer toiletries, you're sure to have a comfortable stay.
How much does it cost to stay in a 4-star hotel in Southern Indiana?
To book a 4-star hotel in Southern Indiana that's within your budget, take advantage of Expedia's handy filters. Take a look at what's available during your preferred dates and use our pricing filter to set your limit. You can also sort your results by the most budget-friendly option first.

  • Search for the lowest price from ₩144,968

What's the difference between 5-star and 4-star hotels in Southern Indiana?
Give yourself the luxury treatment during your Southern Indiana escape by checking in to a 4-star hotel. As well as featuring upmarket surroundings, these properties are typically packed with amenities such as large beds, bathrobes and plenty more. A 5-star hotel will go the extra mile to make your stay an even more indulgent and memorable one. 24-hour concierge assistance, luxurious spas and world-class dining are a few of the exclusive services and conveniences you'll likely be able to enjoy.