A bench, a bicycle, and a lake surrounded by trees.

Upstate South Carolina 4 Stars Hotels

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
Oct 7 - Oct 8
Tomorrow
Oct 8 - Oct 9
This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

Our top choices for Upstate South Carolina 4-star hotels

A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
An outdoor dining area with multiple tables and chairs, large windows, and a view of greenery.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.
A modern interior with a fireplace, plush seating, and a stone accent wall.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
MARIA
₩520,677
₩589,926 total
includes taxes & fees
Oct 11 - Oct 12
Grand Bohemian Lodge Greenville, Autograph Collection
A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A modern living room with a fireplace, seating area, and a bar with shelves of bottles.

2. Hotel Hartness

Hotel Hartness
Greenville
United States
Kodjo
₩223,192
₩297,048 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Hartness
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
Meeting facility
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.
A lobby with patterned flooring, a grand staircase, and elegant furniture.

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Karen
₩226,207
₩260,308 total
includes taxes & fees
Nov 1 - Nov 2
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.
A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.
A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Gregory
₩194,083
₩213,491 total
includes taxes & fees
Nov 1 - Nov 2
Mint House Greenville Downtown by Kasa
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

5. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Amy
₩215,632
₩239,350 total
includes taxes & fees
Oct 18 - Oct 19
The Abernathy of Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
An outdoor patio with wicker furniture, a round table, and a fountain.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
₩279,747
₩310,521 total
includes taxes & fees
Oct 13 - Oct 14
The Shepherd Hotel Downtown Clemson
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A well-furnished living room with a chandelier, wooden furniture, and a view through a window.
A modern building with a large illuminated logo reading "TOPGOLF" on the facade.
A spacious indoor venue with rows of white chairs adorned with purple sashes, large windows, and a modern ceiling design.

7. Greenville Marriott

Greenville Marriott
Greenville
United States
John
₩163,297
₩185,015 total
includes taxes & fees
Oct 18 - Oct 19
Greenville Marriott
A white, two-story house with a front porch, surrounded by trees and shrubs.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.
A bedroom with two beds, a TV, and a fireplace.
A two-story building with a white exterior, a front door, and a balcony.

8. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
United States
Christine
₩151,063
₩167,687 total
includes taxes & fees
Oct 30 - Oct 31
Liberty Hall Bed and Breakfast
A modern building with outdoor seating and a garden.
A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.
A row of modern, two-story buildings with a covered patio area.

9. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveler
₩331,098
₩474,635 total
includes taxes & fees
Oct 8 - Oct 9
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.
A swimming pool with lounge chairs and a building with balconies.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.

10. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
₩560,832
₩616,915 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A multi-story residential building with balconies, a stone archway entrance, and a sign indicating it is part of Century Park at Taft Community.
A modern kitchen with dark cabinetry, a stainless steel range, and a granite countertop.
A modern kitchen with dark wood cabinets, a black refrigerator, a microwave, and a stainless steel sink. There are two bar stools at the island, and a flat-screen TV mounted on the wall.

11. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A modern living room with a flat-screen TV, two leather chairs, a wooden dining table, and a potted plant.
A modern kitchen with stainless steel appliances, a dining area with a table and chairs, and a TV mounted on a wooden cabinet.
A multi-story building with a symmetrical facade, large windows, and two flags on top.

12. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.
A cozy living room with a fireplace, leather armchair, and a large window.
A spacious living area with a high ceiling, wooden beams, a grey sofa, a brown leather chair, and a dining table with a plant.

13. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!
An indoor swimming pool with clear lanes, a covered roof, and a bench area.
Interior
A two-story yellow house with a front porch, a small garden, and a pathway leading to the entrance.
A two-story yellow house with a front porch, surrounded by greenery and a driveway.

14. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
Salem
Wooded Keowee Key Retreat Near Golf & Trails
Interior
A marina with boats docked, a wooden pier, and a clear sky.
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a sink.
A multi-story hotel with a parking lot and a view of a lake.

15. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
United States
Kathleen
Lake Keowee Condo w/ Balcony & Resort Amenities!
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A sandy beach with a calm lake surrounded by trees.
A multi-story hotel with a parking lot and a view of a lake.
A spacious dining area with a wooden table, chairs, and a chandelier. A cozy seating area with a sofa and chairs is visible in the background.

16. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
United States
Shawn
Lake Keowee Condo: Resort Pools & Lake Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A dining area with a wooden table and chairs, a kitchen with white cabinets, and a staircase with a white railing.
A swimming pool with a view of a lake and docked boats.
A marina with boats docked, surrounded by greenery and trees.

17. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.
A sandy beach with a calm lake surrounded by trees.
An aerial view of a residential area with houses, a golf course, and a lake in the background.

18. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
A wooden gazebo with a roof and a table and chairs inside, surrounded by trees and overlooking a lake.
A modern building with a prominent wooden entrance canopy, stone pillars, and a clear sky.
A spacious hotel lobby with a bar area, seating arrangements, and large windows offering views.
A modern kitchen with a stainless steel sink, pendant lighting, and a view to a living area with a sofa and a staircase.

19. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
A swimming pool with a view of the lake and docked boats.
A modern living room with a large window, a flat-screen TV, a leather sofa, a coffee table, and a bookshelf.
A modern kitchen with a central island, stainless steel appliances, wooden cabinets, and a window providing natural light.
A marina with boats docked, surrounded by greenery and trees.

20. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
An aerial view of a park with a winding path, trees in autumn colors, and a bridge.
Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Hotel Hartness

Hotel Hartness

10/10 Excellent
"One of my favorite hotels so far. Beautiful grounds and well-appointed rooms. Excellent service. Great trails, beautiful location."
jacques 2-night trip
Posted 2 days ago
Hotel Hartness
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent
"Fantastic in every way!"
MARIA 1-night trip
Posted 3 days ago
Grand Bohemian Lodge Greenville, Autograph Collection
Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa

10/10 Excellent
"Three bedroom and two bath unit was beautiful and within 2-3 minute walking distance of the falls and downtown. Easy to book, and the check-in and check-out instructions was easy. Within 6-8 driving minutes to Bon Secours Wellness Arena. Loved our stay."
Marilyn 1-night trip
Posted 4 days ago
Mint House Greenville Downtown by Kasa

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.
  • Search for the lowest price from ₩167,687
What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.

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