A bench, a bicycle, and a lake surrounded by trees.

Upstate South Carolina 4 Stars Hotels

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
Sep 30 - Oct 1
Tomorrow
Oct 1 - Oct 2
This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Our top choices for Upstate South Carolina 4-star hotels

A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.
A modern interior with a fireplace, plush seating, and a stone accent wall.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
Michael
₩526,702
₩596,753 total
includes taxes & fees
Oct 11 - Oct 12
Grand Bohemian Lodge Greenville, Autograph Collection
A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.
A modern living room with a fireplace, seating area, and a bar with shelves of bottles.
A bar with multiple shelves of liquor bottles and glasses hanging above.

2. Hotel Hartness

Hotel Hartness
Greenville
United States
Kodjo
₩206,053
₩278,139 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Hartness
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.
Meeting facility
A lobby with patterned flooring, a grand staircase, and elegant furniture.

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Karen
₩228,824
₩263,319 total
includes taxes & fees
Oct 18 - Oct 19
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.
A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Gregory
₩196,329
₩215,962 total
includes taxes & fees
Oct 4 - Oct 5
Mint House Greenville Downtown by Kasa
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

5. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
₩218,128
₩242,122 total
includes taxes & fees
Oct 18 - Oct 19
The Abernathy of Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
An outdoor patio with wicker furniture, a round table, and a fountain.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
₩282,984
₩314,111 total
includes taxes & fees
Oct 7 - Oct 8
The Shepherd Hotel Downtown Clemson
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A well-furnished living room with a chandelier, wooden furniture, and a view through a window.
A banquet hall with round tables set for dining, large windows, and a stage with curtains.
A spacious indoor venue with rows of white chairs adorned with purple sashes, large windows, and a modern ceiling design.

7. Greenville Marriott

Greenville Marriott
Greenville
United States
John
₩165,187
₩187,157 total
includes taxes & fees
Oct 11 - Oct 12
Greenville Marriott
A white, two-story house with a front porch, surrounded by trees and shrubs.
A two-story building with a white exterior, a front door, and a balcony.
A bedroom with two beds, a TV, and a fireplace.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.

8. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
United States
Christine
₩154,477
₩171,456 total
includes taxes & fees
Oct 27 - Oct 28
Liberty Hall Bed and Breakfast
A modern building with outdoor seating and a garden.
A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.

9. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveler
₩362,957
₩510,957 total
includes taxes & fees
Oct 4 - Oct 5
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A bar with a large window view of mountains and a chandelier.
A swimming pool with lounge chairs and a building with balconies.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.

10. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
₩567,322
₩624,054 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A modern kitchen with dark wood cabinets, a black refrigerator, a microwave, and a stainless steel sink. There are two bar stools at the island, and a flat-screen TV mounted on the wall.
A modern kitchen with dark cabinetry, a stainless steel range, and a granite countertop.
A modern kitchen with white cabinetry, dark blue walls, and a patterned floor.

11. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A modern kitchen with stainless steel appliances, a dining area with a table and chairs, and a TV mounted on a wooden cabinet.
A modern living room with a flat-screen TV, two leather chairs, a wooden dining table, and a potted plant.
A modern kitchen with stainless steel appliances, dark wooden cabinets, a dining table with chairs, and a potted plant.

12. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.
A spacious living area with a high ceiling, wooden beams, a grey sofa, a brown leather chair, and a dining table with a plant.
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.

13. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!
An indoor swimming pool with clear lanes, a covered roof, and a bench area.
Interior
Interior
A two-story yellow house with a front porch, surrounded by greenery and a driveway.

14. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
Salem
Wooded Keowee Key Retreat Near Golf & Trails
A swimming pool with a view of the lake and docked boats.
A marina with boats docked, surrounded by greenery and trees.
A spacious living area with a high ceiling, a large window with a view of trees, a kitchen with a bar, and a comfortable seating area with a sofa and ottomans.
A modern living room with a large window, a flat-screen TV, a leather sofa, a coffee table, and a bookshelf.

15. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
Interior
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a sink.
A marina with boats docked, a wooden pier, and a clear sky.
A hallway with a wooden bench, a chandelier, a door, and a wall with a sign.

16. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
Lake Keowee Condo w/ Balcony & Resort Amenities!
A wooden gazebo with a roof and a table and chairs inside, surrounded by trees and overlooking a lake.
A modern kitchen with a stainless steel sink, pendant lighting, and a view to a living area with a sofa and a staircase.
A modern living room with a sofa, a coffee table, and a fireplace.
A modern building with a prominent wooden entrance canopy, stone pillars, and a clear sky.

17. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A spacious dining area with a wooden table, chairs, and a chandelier. A cozy seating area with a sofa and chairs is visible in the background.
A multi-story hotel with a parking lot and a view of a lake.
An indoor swimming pool with clear lanes, a covered roof, and a bench area.

18. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
Lake Keowee Condo: Resort Pools & Lake Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A spacious living room with a fireplace, a television, and a staircase leading to an upper level.
A dining area with a wooden table and chairs, a kitchen with white cabinets, and a staircase with a white railing.
A marina with boats docked, surrounded by greenery and trees.

19. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.
An aerial view of a residential area with houses, a golf course, and a lake in the background.
A sandy beach with a calm lake surrounded by trees.

20. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
An aerial view of a park with a winding path, trees in autumn colors, and a bridge.
Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent
"The room was very clean and comfortable. Staff was helpful and friendly. The lobby is to die for with the displays of Native American art and jewelry. A fun place e to stay with convenient location."
ALICE 1-night trip
Posted 8 hours ago
Grand Bohemian Lodge Greenville, Autograph Collection
Hotel Hartness

Hotel Hartness

10/10 Excellent
"Great property"
Kenneth 2-night trip
Posted 2 days ago
Hotel Hartness

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.
  • Search for the lowest price from ₩171,456
What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.

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