A bench, a bicycle, and a lake surrounded by trees.

Upstate South Carolina 4 Stars Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Upstate South Carolina 4 Star Hotels

Tonight
Oct 15 - Oct 16
Tomorrow
Oct 16 - Oct 17
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Our top choices for Upstate South Carolina 4-star hotels

A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.
A modern interior with a fireplace, plush seating, and a stone accent wall.
An outdoor dining area with multiple tables and chairs, large windows, and a view of greenery.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
colleen
₩469,928
₩532,430 total
includes taxes & fees
Nov 15 - Nov 16
Grand Bohemian Lodge Greenville, Autograph Collection
A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A bar with multiple shelves of liquor bottles and glasses hanging above.
A modern living room with a fireplace, seating area, and a bar with shelves of bottles.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.

2. Hotel Hartness

Hotel Hartness
Greenville
United States
Kodjo
₩231,426
₩306,549 total
includes taxes & fees
Oct 21 - Oct 22
Hotel Hartness
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A banquet hall with round tables, chandeliers, and ornate windows.
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.
A lobby with patterned flooring, a grand staircase, and elegant furniture.

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Karen
₩226,908
₩261,116 total
includes taxes & fees
Nov 8 - Nov 9
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Gregory
₩163,132
₩179,444 total
includes taxes & fees
Oct 29 - Oct 30
Mint House Greenville Downtown by Kasa
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

5. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Amy
₩228,385
₩253,508 total
includes taxes & fees
Nov 1 - Nov 2
The Abernathy of Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
₩280,614
₩311,481 total
includes taxes & fees
Oct 26 - Oct 27
The Shepherd Hotel Downtown Clemson
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A well-furnished living room with a chandelier, wooden furniture, and a view through a window.
A modern building with a large illuminated logo reading "TOPGOLF" on the facade.
A banquet hall with round tables set for dining, large windows, and a stage with curtains.

7. Greenville Marriott

Greenville Marriott
Greenville
United States
John
₩153,062
₩173,419 total
includes taxes & fees
Nov 8 - Nov 9
Greenville Marriott
A white, two-story house with a front porch, surrounded by trees and shrubs.
A dining area with round tables, black chairs, and white tablecloths.
A two-story building with a white exterior, a front door, and a balcony.
A bedroom with two beds, a TV, and a fireplace.

8. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
United States
Christine
₩122,660
₩136,153 total
includes taxes & fees
Oct 20 - Oct 21
Liberty Hall Bed and Breakfast
A modern building with outdoor seating and a garden.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.
A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.

9. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveler
₩346,014
₩491,383 total
includes taxes & fees
Nov 15 - Nov 16
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A swimming pool with lounge chairs and a building with balconies.
A bar with a large window view of mountains and a chandelier.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.

10. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
₩562,570
₩618,827 total
includes taxes & fees
Nov 15 - Nov 16
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A multi-story residential building with balconies, a stone archway entrance, and a sign indicating it is part of Century Park at Taft Community.
A modern kitchen with white cabinetry, dark blue walls, and a patterned floor.
A modern kitchen with dark wood cabinets, a black refrigerator, a microwave, and a stainless steel sink. There are two bar stools at the island, and a flat-screen TV mounted on the wall.

11. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A modern kitchen with stainless steel appliances, dark wooden cabinets, a dining table with chairs, and a potted plant.
A modern living room with a flat-screen TV, two leather chairs, a wooden dining table, and a potted plant.
A modern kitchen with stainless steel appliances, a dining area with a table and chairs, and a TV mounted on a wooden cabinet.

12. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A spacious living area with a high ceiling, wooden beams, a grey sofa, a brown leather chair, and a dining table with a plant.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.

13. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!
An indoor swimming pool with clear lanes, a covered roof, and a bench area.
Interior
Interior
A two-story yellow house with a front porch, a small garden, and a pathway leading to the entrance.

14. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
Salem
Wooded Keowee Key Retreat Near Golf & Trails
Interior
A multi-story hotel with a parking lot and a view of a lake.
A hallway with a wooden bench, a chandelier, a door, and a wall with a sign.
A marina with boats docked, a wooden pier, and a clear sky.

15. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
United States
Kathleen
Lake Keowee Condo w/ Balcony & Resort Amenities!
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A sandy beach with a calm lake surrounded by trees.
An indoor swimming pool with clear lanes, a covered roof, and a bench area.
A multi-story hotel with a parking lot and a view of a lake.

16. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
United States
Shawn
Lake Keowee Condo: Resort Pools & Lake Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A spacious living room with a fireplace, a television, and a staircase leading to an upper level.
A swimming pool with a view of a lake and docked boats.
A marina with boats docked, surrounded by greenery and trees.

17. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
An aerial view of a residential area with houses, a golf course, and a lake in the background.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.
A sandy beach with a calm lake surrounded by trees.

18. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
A wooden gazebo with a roof and a table and chairs inside, surrounded by trees and overlooking a lake.
A spacious hotel lobby with a bar area, seating arrangements, and large windows offering views.
A modern living room with a sofa, a coffee table, and a fireplace.
A modern building with a prominent wooden entrance canopy, stone pillars, and a clear sky.

19. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
A swimming pool with a view of the lake and docked boats.
A modern kitchen with a central island, stainless steel appliances, wooden cabinets, and a window providing natural light.
A spacious living area with a high ceiling, a large window with a view of trees, a kitchen with a bar, and a comfortable seating area with a sofa and ottomans.
A marina with boats docked, surrounded by greenery and trees.

20. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
An aerial view of a park with a winding path, trees in autumn colors, and a bridge.
Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa

10/10 Excellent
"Great location."
Anonymous traveler 1-night trip
Posted 10 hours ago
Mint House Greenville Downtown by Kasa
Hotel Hartness

Hotel Hartness

10/10 Excellent
"Beautiful property and very friendly staff! Highly recommend!"
Nicole 1-night trip
Posted 12 hours ago
Hotel Hartness

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.
  • Search for the lowest price from ₩136,153
What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.

Explore a world of travel with Expedia