A city skyline with modern buildings and a waterfront.

Business Hotels in South America

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on South America Business Hotels

This weekend
Aug 7 - Aug 9
Next weekend
Aug 14 - Aug 16
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top South America Hotel Reviews

InterContinental São Paulo by IHG

InterContinental São Paulo by IHG

10/10 Excellent
"We ended up extending our stay to deal with emergency health issues. The hotel staff were tremendously kind and helpful. We’re so grateful to them for everything. Cannot recommend this place enough! Would come back in a minute if we could."
Suzanne 3-night trip
Posted 3 hours ago
InterContinental São Paulo by IHG

Explore a world of travel with Expedia

Frequently asked questions

Why book your business-friendly hotel in South America with Expedia?
Here at Expedia, our top task is to help you choose the perfect stay at the right price. From luxurious, corporate-friendly getaways to affordable hotels filled with handy amenities, you'll have your next work trip organized in just a few clicks.
How can I find cheap business-friendly hotels in South America?
When work takes you to South America, our "business friendly" filter will help you find the right hotel. From fast WiFi to meeting rooms and workspaces, they have the amenities you need to do your job. You can also narrow your search by your budget and preferred star rating to view the cheapest properties.