Illinois Medical District Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ₩234,741 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Illinois Medical District

Find the best Illinois Medical District areas and neighborhoods for the activities you enjoy most. Learn more about Illinois Medical District
Downtown Chicago showing a city

Downtown Chicago

5 out of top 10 points of interest in this area

The heart of the Midwest’s glittering metropolis has many offerings, from shopping and dining to parks, museums and exciting contemporary public art.

Find hotels in Downtown Chicago

Illinois Medical District Hotel Deals

Hampton Inn & Suites Chicago Medical District UIC

Hampton Inn & Suites Chicago Medical District UIC

2.5 out of 5
710 S Seeley Avenue Chicago IL
Fully refundableReserve now, pay when you stay
The price is ₩127,526 per night from Dec 7 to Dec 8
₩127,526
₩149,703 total
Dec 7 - Dec 8
includes taxes & fees
9.6/10 Exceptional! (348 reviews)
Room was very clean and comfortable. Would have appreciated a disposable bathroom glass for use when brushing teeth or taking a pill. Had to take a cup from the coffee station.

Reviewed on Nov 26, 2025

Hampton Inn & Suites Chicago Medical District UIC
Palmer House a Hilton Hotel

Palmer House a Hilton Hotel

4 out of 5
17 E Monroe St Chicago IL
Fully refundableReserve now, pay when you stay
The price is ₩160,166 per night from Dec 28 to Dec 29
₩160,166
₩224,732 total
Dec 28 - Dec 29
includes taxes & fees
8.4/10 Very Good! (2,102 reviews)
Excellent check in experience and follow up from Ella. The lobby bar area was beautiful with the Christmas trees and other decorations.

Reviewed on Nov 27, 2025

Palmer House a Hilton Hotel
Embassy Suites by Hilton Chicago Downtown River North

Embassy Suites by Hilton Chicago Downtown River North

4 out of 5
600 N State St Chicago IL
Fully refundableReserve now, pay when you stay
The price is ₩134,546 per night from Dec 7 to Dec 8
₩134,546
₩157,946 total
Dec 7 - Dec 8
includes taxes & fees
8.4/10 Very Good! (5,291 reviews)
All above.

Reviewed on Nov 24, 2025

Embassy Suites by Hilton Chicago Downtown River North
See all 4,806 properties in Illinois Medical District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Illinois Medical District vacation package cost?
Starting from just , a vacation package is your portal to affordable travel. Custom make your Illinois Medical District trip by picking from our great range of airfares, hotels and rental cars.
How do I get a cheap travel package to Illinois Medical District?
By bundling. Hotels, rental cars and flights — combine whatever you need into an Illinois Medical District vacation package to save loads of cash. Score even more deals when you add extras such as activities or tours to your booking. But that's not the only impressive part. You have the freedom to tailor your vacation your way. We offer more than 550 partner airlines and 1,000,000 hotel options globally, so that everyone has a chance to travel and live out those vacation fantasies.
Where should I stay in Illinois Medical District?
Most travelers who visit Illinois Medical District put both University of Illinois Chicago and United Center on their sightseeing itineraries. Why not choose a hotel that's close to these great attractions?
What are the top hotels in Illinois Medical District?
Reserve a room at Hyatt Place Chicago Medical/University District. It's one of the area's most in-demand hotels. Another great option in Illinois Medical District is Hyatt House Chicago Medical/University District.
How far in advance should I book my Illinois Medical District vacation?
Browse Expedia to compare international flights as soon as possible. In most cases, you can purchase a seat up to 12 months in advance. If you can't find your preferred air carrier, or you've left things to the last moment, don't worry. The lowest prices to Illinois Medical District sometimes occur just weeks before the date of departure.
What does an Expedia Illinois Medical District travel package include?
That depends on what kind of trip you're contemplating. Illinois Medical District vacation deals can include hotels, car rentals and flights. You can mix and match to create the package that suits your budget and style. You can also add on activities and experiences after you've booked to pick up even bigger discounts.
What should I know before booking an Illinois Medical District travel package?
A travel package can be easier on the wallet than separately booking everything you need for your getaway. For example, combine your hotels, flights and rental cars and save a packet. Whatever type of vacation you have in mind, there's bound to be a package that's perfect for you.
Can I choose my airline with an Illinois Medical District Expedia vacation package?
Most definitely. We offer more than 550 airlines around the world, so you can design your Illinois Medical District trip according to your budget and style.
If I'm not able to travel, can I cancel my Illinois Medical District vacation package?
Certainly, and we're here to help. You may be able to change or cancel your Illinois Medical District vacation package for free if you booked in the last 24 hours. But you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, look up our Customer Service Portal for more information.

Discover the most popular places to visit in Illinois Medical District

Navy Pier featuring a sunset and rides

Navy Pier

A ferris wheel, shopping, restaurants and more can be found in this waterfront entertainment district.

Navy Pier
Millennium Park featuring a city, modern architecture and fall colors

Millennium Park

A landmark gathering place for locals and visitors who come to admire the unique art, architecture and landscape.

Millennium Park
Grant Park showing a garden and night scenes

Grant Park

Chicago’s front yard is a pretty landscaped park, which is home to public art displays, museums, themed gardens and international music festivals.

Grant Park
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.