Find hotels in Santa Ana, Antigua Guatemala from ₩60,951

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Ana hotels

Casa Buho B&B

Casa Buho B&B
3.0 star property
Santa Ana
9.2 out of 10, Wonderful, (48)
"Great place !!"
United States
Abner Israel Polanco
The price is ₩76,130
₩92,879 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Casa Buho B&B

Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
8.6 out of 10, Excellent, (12)
"Space was clean and had a cozy vibe."
United States
Evelin
Villas Santa Ana-Ricardo

Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (21)
"Nice clean affordable accomodations and very accomodating and amicable hosts."
United States
Feng
The price is ₩69,918
₩85,300 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hostal Casa Buho

Casa Quetzalli Los Nazarenos

Casa Quetzalli Los Nazarenos
2.0 star property
2.2 km from Santa Ana
9.4 out of 10, Exceptional, (24)
"The room was very clean and large. I stayed in room 1 and the car noises were very present but after a day of hiking it was not hard to fall asleep."
United States
Tina
The price is ₩49,960
₩60,951 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Casa Quetzalli Los Nazarenos

Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.6 out of 10, Excellent, (1002)
"Great room"
United States
Elvin
Hotel Soleil La Antigua

Good Hotel Guatemala City

Good Hotel Guatemala City
3.0 star property
23.9 km from Santa Ana
9.4 out of 10, Exceptional, (243)
"Great place to stay in the city"
United States
Cesar
The price is ₩141,056
₩172,089 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Good Hotel Guatemala City

Barceló Guatemala City

Barceló Guatemala City
4.5 star property
22.7 km from Santa Ana
9.2 out of 10, Wonderful, (3118)
"Friendly staff , wonderful beds. Breakfast was great and large variety of foods. "
United States
Parker
The price is ₩109,855
₩134,023 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Barceló Guatemala City

Why Not Hotel

Why Not Hotel
3.0 star property
Historic Center, 1.5 km from Santa Ana
8.4 out of 10, Very Good, (147)
"Great hotel! Absolutely recommend it. "
United States
Jorge
The price is ₩57,509
₩70,161 total
includes taxes & fees
Dec 18 - Dec 19
Why Not Hotel

Naif Boutique Hotel

Naif Boutique Hotel
3.0 star property
Historic Center, 1.4 km from Santa Ana
9.0 out of 10, Wonderful, (372)
"Well located, friendly staff. Would stay again."
United States
Cristian Paolo
The price is ₩171,057
₩208,690 total
includes taxes & fees
Dec 23 - Dec 24
Naif Boutique Hotel

Hotel La Sin Ventura

Hotel La Sin Ventura
2.0 star property
Historic Center, 1.3 km from Santa Ana
8.8 out of 10, Excellent, (143)
"Really glad we stayed here. This hotel has the best staff ever. Perfect location. "
United States
Greg
Hotel La Sin Ventura

Hotel Panchoy

Hotel Panchoy
3.0 star property
Historic Center, 1.1 km from Santa Ana
8.4 out of 10, Very Good, (274)
"Nice staff and good location "
United States
Luis
The price is ₩85,175
₩103,914 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hotel Panchoy

Kawilal Hotel

Kawilal Hotel
3.5 star property
13.7 km from Santa Ana
9.0 out of 10, Wonderful, (132)
"Beautiful pool and spa with thermal water! Only hotel guests are allowed to have use of the installations. The massage was amazing! I would love to go back "
United States
Ana
The price is ₩158,603
₩193,495 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Kawilal Hotel

Casa Santa Rosa Hotel Boutique

Casa Santa Rosa Hotel Boutique
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.6 out of 10, Exceptional, (319)
"Excellent hotel. The property is incredible, with lush gardens and very quiet. Staff is friendly. Room were clean and comfortable. So would stay again."
United States
Alejandro
The price is ₩196,496
₩239,726 total
includes taxes & fees
Dec 18 - Dec 19
Casa Santa Rosa Hotel Boutique

Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (647)
"Friendly staff, clean rooms the location was excellent. "
United States
Elias
The price is ₩236,583
₩324,464 total
includes taxes & fees
Dec 27 - Dec 28
Hotel Posada de Don Rodrigo Antigua

Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center
4.5 star property
20.2 km from Santa Ana
9.0 out of 10, Wonderful, (1007)
"Very nice hotel"
United States
Jeudy
The price is ₩157,429
₩192,063 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Tikal Futura Hotel & Convention Center

Hilton Guatemala City

Hilton Guatemala City
4.5 star property
25.9 km from Santa Ana
8.6 out of 10, Excellent, (680)
"Great stay and amazing property "
United States
Hugo
The price is ₩151,995
₩185,433 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hilton Guatemala City

Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1003)
"Great place to stay. "
United States
tania
The price is ₩242,122
₩304,200 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Los Pasos Boutique Hotel & Spa

Ole España

Ole España
2.5 star property
20.8 km from Santa Ana
9.4 out of 10, Exceptional, (27)
"Very nice hotel , just couldn’t walk anywhere, but great staff "
United States
John
The price is ₩87,232
₩106,423 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Ole España

La Inmaculada Hotel

La Inmaculada Hotel
3.5 star property
23.7 km from Santa Ana
9.2 out of 10, Wonderful, (610)
"Everything was perfect, the room was perfectly cleaned every day, the restaurant is amazing, the people that wirks there amazing!!"
United States
Claudia
La Inmaculada Hotel

Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1006)
"Amazing hotel with beautiful gardens, great rooms, helpful staff and the top breakfast in Antigua. "
United States
Audrey
The price is ₩301,053
₩396,449 total
includes taxes & fees
Dec 18 - Dec 19
Hotel Camino Real Antigua
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on Expedia customer reviews, Casa Buho B&B is the highest ranked property in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 17 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.