A modern building with a unique triangular roof and a central spire.

Find hotels in Santa Lucia, Syracuse

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Lucia hotels

A historic building with ornate balconies, a grand entrance, and flags of the European Union and Italy.

1. Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (702 reviews)
"We enjoyed our stay"
United States
Anna
The price is ₩115,779
₩131,990 total
includes taxes & fees
Nov 1 - Nov 2
Grande Albergo Alfeo
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.

2. Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.4 out of 10, Exceptional, (299 reviews)
"Staff was very friendly and helpful"
Canada
Dena
The price is ₩243,233
₩282,847 total
includes taxes & fees
Oct 29 - Oct 30
Caportigia Boutique Hotel
A balcony with wicker chairs and a glass table overlooking a marina with boats.

3. Fortaleza Charme House

Fortaleza Charme House
Santa Lucia
10.0 out of 10, Exceptional, (43 reviews)
"Beautiful accomodation, perfect location close to restauranys and attractions, clean room/all renovated with style, friendly personnel, nice view of the port"
Canada
Martine
The price is ₩229,610
₩261,763 total
includes taxes & fees
Nov 1 - Nov 2
Fortaleza Charme House
A modern hotel room with a flat-screen TV mounted on a dark wall, a white desk with a remote control, a bed with a black and white patterned bedspread, and a window with curtains.

4. Nostos rooms & Apartments

Nostos rooms & Apartments
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (292 reviews)
"A really nice room, the bed was extremely comfortable and the staff were very friendly."
United Kingdom
Michael
The price is ₩108,413
₩123,596 total
includes taxes & fees
Oct 27 - Oct 28
Nostos rooms & Apartments
A hotel room with a large bed, a chair, a small table, and a chandelier.

5. Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri
4.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (46 reviews)
"Good central location & nice breakfast selection "
Australia
Alan
The price is ₩139,321
₩158,833 total
includes taxes & fees
Nov 1 - Nov 2
Hotel Palazzo Cavalieri
A neatly made bed with a dark quilt, white pillows, and a beige headboard. There are two bedside lamps on either side of the bed.

6. Melody rooms

Melody rooms
Santa Lucia
10.0 out of 10, Exceptional, (1 review)
The price is ₩53,251
₩60,701 total
includes taxes & fees
Oct 12 - Oct 13
Melody rooms
A room with a table and chairs, a view of a harbor with boats and buildings, and a clear sky.

7. Lakkios

Lakkios
3.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (78 reviews)
"The location of this place is amazing and that balcony view iconic. Staff super helpful too."
Canada
Marsel
The price is ₩131,348
₩149,740 total
includes taxes & fees
Oct 27 - Oct 28
Lakkios
A woman in a black swimsuit sitting in a hot tub overlooking a beach with a clear sky and the sun shining.

8. Re Dionisio Luxury Suites

Re Dionisio Luxury Suites
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (58 reviews)
"Wonderful property, excellent staff and the most amazing view from the apartment"
Australia
Anthony
The price is ₩342,919
₩392,591 total
includes taxes & fees
Oct 4 - Oct 5
Re Dionisio Luxury Suites
A hot tub with a view of a marina.

9. Casa Miranda Boutique

Casa Miranda Boutique
Santa Lucia
8.8 out of 10, Excellent, (3 reviews)
"This was one of the best hotel stays I’ve ever had. Simply, you won’t be disappointed from location, excellent service and the most helpful and welcoming staffs. Highly recommended"
United States
Hossein
The price is ₩406,542
₩462,486 total
includes taxes & fees
Oct 16 - Oct 17
Casa Miranda Boutique
An open balcony with a table and chairs, potted plants, and a view of a building with balconies and windows.

10. Calafatari B&B

Calafatari B&B
3.0 star property
Santa Lucia
9.8 out of 10, Exceptional, (18 reviews)
"Clean, very convenient for exploring Ortigia. Nice continental breakfast."
United States
Mary
The price is ₩184,219
₩210,010 total
includes taxes & fees
Nov 2 - Nov 3
Calafatari B&B
A terrace with white tables and chairs, white umbrellas, and a view of the sea.

11. Giuggiulena Villa

Giuggiulena Villa
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (132 reviews)
"We had an amazing time. Sabrina and Claudia were wonderful. The place is top notch in everything they do. The food was so fresh and delicious . I was sad when i had to leave them. High praise for this hotel. The views breath taking."
United States
Duane
The price is ₩299,560
₩344,897 total
includes taxes & fees
Oct 6 - Oct 7
Giuggiulena Villa
A modern dining area with a white table, green chairs, and a potted plant.

12. San Nicola Rooms Siracusa

San Nicola Rooms Siracusa
Santa Lucia
9.4 out of 10, Exceptional, (11 reviews)
"The breakfast was great! The hosts were super friendly and helpful!"
United States
Lin
The price is ₩160,113
₩182,530 total
includes taxes & fees
Oct 16 - Oct 17
San Nicola Rooms Siracusa
A balcony with a table set for two, a chair, and a view of a building with multiple windows and balconies.

13. B&B Nike

B&B Nike
Santa Lucia
9.0 out of 10, Wonderful, (92 reviews)
"Great location and comfortable stay!"
United States
Rosa
The price is ₩109,881
₩125,257 total
includes taxes & fees
Nov 1 - Nov 2
B&B Nike
A balcony with potted plants and a metal railing.

14. Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (387 reviews)
"Fantastic breakfast, great cakes and good coffee. The rooms were comfortable and the location is great for all the important places to be in Siracusa. It was quiet and peaceful and the staff were helpful and friendly."
United Kingdom
Richard
The price is ₩73,805
₩84,136 total
includes taxes & fees
Oct 29 - Oct 30
Piccolo Hotel Casa Mia
A modern bedroom with a bed, bedside table, and a unique feature of a table with a fire effect.

15. B&B IL MORO

B&B IL MORO
Santa Lucia
4.0 out of 10, (1 review)
"Personne sur place pour nous aider. La carte de la chambre était défectueuse dès l'arrivée. Par la suite l'électricité a manqué à 21h, nous avons du contacter les propriétaires via What's App dans le noir. Nous apprécions faire affaire avec des humains et non des applications impersonnelles et des vidéos. Le lit était petit et inconfortable. Pas d'oreiller d'extra ni de boîte de mouchoirs. Le quartier est lugubre."
Canada
Celine B. La
The price is ₩100,907
₩115,034 total
includes taxes & fees
Nov 2 - Nov 3
B&B IL MORO
A table with two wine glasses and a decorative item, viewed through a window overlooking a parking area with cars and greenery.

16. Gymnasium

Gymnasium
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (43 reviews)
"Nice kitchen area, centrally located."
United States
Richard
The price is ₩78,808
₩89,839 total
includes taxes & fees
Oct 11 - Oct 12
Gymnasium
A bedroom with a stone wall, a bed with a wooden headboard, a tray with a plant, and a window with curtains.

17. B&B Siracusa

B&B Siracusa
Santa Lucia
9.0 out of 10, Wonderful, (60 reviews)
"Good location, very modern clean accommodation."
Canada
Malcolm
The price is ₩105,632
₩120,417 total
includes taxes & fees
Nov 2 - Nov 3
B&B Siracusa
A marina with numerous boats docked, a clear sky, and a building with outdoor seating.

18. Regina Margherita

Regina Margherita
Santa Lucia
7.6 out of 10, Good, (20 reviews)
"The area is so close to the Ortigia Island where the beautiful cathedral and Doumo are. Lovely walk around the entire island and areas to go in the water If you like. Many dining options and shopping too. Wonderful area!"
United States
Laura
The price is ₩104,486
₩119,118 total
includes taxes & fees
Oct 7 - Oct 8
Regina Margherita
A bedroom with a bed, a desk, a chair, a television, and a mirror.

19. Fortuna Guest House

Fortuna Guest House
1.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (20 reviews)
"Hotel was perfect for our 5 day stay,great location within walking distance to supermarkets and city centre. Antonino was a great host and provided clear communication for checking in and any questions about the place. Would highly recommend and visit again in the future."
Italy
Nello
The price is ₩152,269
₩173,587 total
includes taxes & fees
Oct 7 - Oct 8
Fortuna Guest House
A hotel room with a bed, a view of the sea, and a small table with a chair.

20. Eos Sea View Apartment

Eos Sea View Apartment
Santa Lucia
10.0 out of 10, Exceptional, (2 reviews)
"Great location and clean apartment."
United States
Siarhei
The price is ₩258,081
₩294,209 total
includes taxes & fees
Nov 1 - Nov 2
Eos Sea View Apartment
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Lucia

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.
Caportigia Boutique Hotel
5.0 star property
9.4
Exceptional
299 reviews
View
A room with a table and chairs, a view of a harbor with boats and buildings, and a clear sky.
Lakkios
3.0 star property
9.2
Wonderful
78 reviews
View
A modern hotel room with a flat-screen TV mounted on a dark wall, a white desk with a remote control, a bed with a black and white patterned bedspread, and a window with curtains.
Nostos rooms & Apartments
3.0 star property
9.0
Wonderful
292 reviews
View
A hotel room with a large bed, a chair, a small table, and a chandelier.
Hotel Palazzo Cavalieri
4.0 star property
9.0
Wonderful
46 reviews
View
A table with two wine glasses and a decorative item, viewed through a window overlooking a parking area with cars and greenery.
Gymnasium
3.0 star property
8.8
Excellent
43 reviews
View

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most.
A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Travelers come to Ortigia for its seaside views, and you can see top attractions like Cathedral of Syracuse and Piazza del Duomo while you're in town.

A natural rock arch over a body of water with people paddling in kayaks.
Photo by Salvo Cannizzaro
Open Photo by Salvo Cannizzaro

Grottasanta

Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

Ancient ruins with a large amphitheater surrounded by trees.
Photo by William Keller
Open Photo by William Keller

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.

An aerial view of a coastal city with a prominent fortified structure and a densely built urban area in the background.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Top Santa Lucia Hotel Reviews

Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri

10/10 Excellent
"Very responsive staff that helped me organize transportation to and from the airport, accommodation for my baby, and a surprise welcome for my wife’s birthday. Amazing location just outside Ortigia, I honestly preferred staying there than on the island. Highly recommended."
Diego 4-night trip
Posted 8 hours ago
Hotel Palazzo Cavalieri

Frequently asked questions

What is Santa Lucia like?
Santa Lucia is a neighborhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Be sure to check out Porto Piccolo and Ionian Sea while you're in the neighborhood.
Where is the best place to stay in Santa Lucia?
Based on our traveler data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel offers free breakfast and a restaurant. Other good choices for your stay in the area include Nostos rooms & Apartments and Caportigia Boutique Hotel.
How many hotels can I expect to find in Santa Lucia?
Expedia has 313 hotels and other accommodations in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.
If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best options available in Santa Lucia.
Where can I learn more about changing or cancelling my trip to Santa Lucia?
For more details about changing or cancelling your trip to Santa Lucia, click here.
What are the top things to see and do in Santa Lucia?
Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops to visit in the neighborhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica, and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.