Top Santa Lucia Hotels

A modern building with a unique triangular roof and a central spire.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Compare popular hotels in Santa Lucia

Property	Property class	Guest rating
Giuggiulena Villa	3.0 star property	10.0 Exceptional 133 reviews	View
Lakkios	3.0 star property	9.2 Wonderful 80 reviews	View
Caportigia Boutique Hotel	5.0 star property	9.2 Wonderful 300 reviews	View
Nostos rooms & Apartments	3.0 star property	9.0 Wonderful 295 reviews	View
Hotel Palazzo Cavalieri	4.0 star property	9.0 Wonderful 48 reviews	View

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most.

A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Travelers come to Ortigia for its seaside views, and you can see top attractions like Cathedral of Syracuse and Piazza del Duomo while you're in town.

See properties

Ancient ruins with a large amphitheater surrounded by trees.

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

See properties

A natural rock arch over a body of water with people paddling in kayaks.

Grottasanta

Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

See properties

An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.

See properties

An aerial view of a coastal city with a prominent fortified structure and a densely built urban area in the background.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

See properties

Top Santa Lucia Hotel Reviews

Fortaleza Charme House

10/10 Excellent

"The hotel is quite cool - looks unimpressive from the outside but inside the rooms are very modern and clean. We had 2 rooms on the top floor with skylights which had remote-controlled shades. We were given code access to get in - which was perfect as we arrived early and dropped our bags off. We were lucky to fin street parking just across the street from the hotel. The location was awesome. Right next to the bridge to Ortigia. Plenty of coffee shops and restaurants near by. The staff provided helpful recommendations and was very accommodating. We would highly recommend the hotel."

Algila' Ortigia Charme Hotel

8/10 Good

"It's a cute and cosy hotel right next to the ocean. Gorgeous views day and night. Breakfast was very impressive and with lots of varieties to choose. I enjoyed the breakfast a lot. Not sure about the rest of the hotel, the room I stayed, the shower needed some maintenance work. The draining was slow and the doors couldn't closed with complete seal so the water goes out. Be prepared for the small size of the single room, but it was enough for me, especially when I didn't stay in the room during the day. Staff friendliness was mixed. Some were extremely friendly, some were not helpful, but would say 90% of the staff were very friendly, kind, respectful, and willing to help."

Grand Hotel Villa Politi

8/10 Good

"Large older hotel, built in 1862 but renovated. Quiet. Situated in an historic park. Many bus tours stay here. Rooms are clean, fairly large and adequately equipped. Bed needs to be upgraded, mattress is hard and uncomfortable. Shower is in the bathtub, you need to step over the bathtub to access. Limited views from rooms. Convenient city bus stop not far from the main gate to access downtown and Ortigia. Free parking for those with rental cars. Breakfast is okay, typical large group buffet-style with chaotic frenzy to grab fresh items in limited quantities. Restaurant for dinner is okay but overpriced. Much better dining options in town."

Maniace Boutique Hotel Ortigia UNA Esperienze

10/10 Excellent

"We arrived feeling stressed after the drive to the hotel! The lovely young lady on the front desk welcomed us with a warm Smile and arranged for the bartender to bring us a drink outside so we could soak up the afternoon sun and relax. We were served a delicious aperol. The decor throughout the hotel is very tasteful even the corridors to the room. Clean white walls but a hint of original brickwork showing. Comfy beds, crisp white linen. Lovely toiletries in the bathroom. Everywhere was spotless. Great breakfast and amazing service. Lovely location just opposite the pretty pebbly beach and around the corner from the lovely streets full of restaurants, shops and wonderful architecture. Would definitely return."

Frequently asked questions

What is Santa Lucia like?

Santa Lucia is a neighborhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Be sure to check out Porto Piccolo and Ionian Sea while you're in the neighborhood.

Where is the best place to stay in Santa Lucia?

Based on our traveler data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel offers free breakfast and a restaurant. Other good choices for your stay in the area include Nostos rooms & Apartments and Caportigia Boutique Hotel.

How many hotels can I expect to find in Santa Lucia?

Expedia has 313 hotels and other accommodations in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.

If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best options available in Santa Lucia.

Where can I learn more about changing or cancelling my trip to Santa Lucia?

For more details about changing or cancelling your trip to Santa Lucia, click here.

What are the top things to see and do in Santa Lucia?

Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops to visit in the neighborhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica, and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.

Explore a world of travel with Expedia

Car rentals near Piazza del Duomo

Book Hotels in Santa Lucia on Expedia.it

Find hotels in Santa Lucia, Syracuse

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Lucia hotels

1. Grande Albergo Alfeo

2. Caportigia Boutique Hotel

3. Nostos rooms & Apartments

4. Fortaleza Charme House

5. Hotel Palazzo Cavalieri

6. Lakkios

7. Melody rooms

8. B&B Nike

9. Giuggiulena Villa

10. Casa Miranda Boutique

11. Calafatari B&B

12. Piccolo Hotel Casa Mia

13. Regina Margherita

14. Residence Agatocle

15. Syraka Design Rooms & Suites

16. Eos Sea View Apartment

17. San Nicola Rooms Siracusa

18. Re Dionisio Luxury Suites

19. Fortuna Guest House

20. Gymnasium

Compare popular hotels in Santa Lucia

Where to stay in Santa Lucia

Ortigia

Neapolis

Grottasanta

Tiche

Acradina

Top Santa Lucia Hotel Reviews

Fortaleza Charme House

Frequently asked questions

Explore a world of travel with Expedia