Our top choices for Upstate South Carolina hotels

Premium bedding, in-room safe, individually furnished, laptop workspace

Carolina Camp Cedar

Pickens

Julie

₩287,706 total

includes taxes & fees

Feb 24 - Feb 25

Inn on the Square, an Ascend Collection Hotel

Uptown Greenwood

Tracy

₩165,592 total

includes taxes & fees

Mar 22 - Mar 23

Desk, laptop workspace, blackout drapes, iron/ironing board

Baymont by Wyndham Greenwood

Greenwood

Patricia

₩114,300 total

includes taxes & fees

Mar 1 - Mar 2

Holiday Inn Express & Suites Greenwood Mall by IHG

Greenwood

Mark

₩172,092 total

includes taxes & fees

Mar 1 - Mar 2

Hampton Inn Easley

Easley

Thomas

₩214,571 total

includes taxes & fees

Mar 1 - Mar 2

Quality Inn Clinton - Laurens I-26

Clinton

Kimberly

₩121,892 total

includes taxes & fees

Mar 8 - Mar 9

Standard Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout drapes, iron/ironing board

Best Western Seneca-Clemson

Seneca

Tabatha

₩141,987 total

includes taxes & fees

Mar 1 - Mar 2

Inn @ Clemson

Clemson

Keren

Tru by Hilton Seneca Clemson

Seneca

Cindy

₩169,827 total

includes taxes & fees

Mar 3 - Mar 4

Woodspring Suites Greenville Airport

Greenville

Makiya

₩125,679 total

includes taxes & fees

Feb 24 - Feb 25

Lakeside Lodge Clemson

Seneca

Jeffrey

₩195,695 total

includes taxes & fees

Feb 24 - Feb 25

The Inn at Patrick Square

Clemson

Joyce

₩239,198 total

includes taxes & fees

Feb 24 - Feb 25

Home2 Suites by Hilton Duncan

Duncan

Elizabeth

₩185,420 total

includes taxes & fees

Mar 19 - Mar 20

Hampton Inn Greer Greenville, SC

Greer

Tyler

₩219,125 total

includes taxes & fees

Mar 1 - Mar 2

Clemson University's James F. Martin Inn

Clemson

Paige

₩239,198 total

includes taxes & fees

Feb 26 - Feb 27

Quality Inn Seneca Clemson Area US-123

Downtown

Susan

₩132,686 total

includes taxes & fees

Mar 2 - Mar 3

Four Points by Sheraton Spartanburg

Spartanburg

Ashley

₩191,037 total

includes taxes & fees

Mar 8 - Mar 9

The Abernathy of Clemson

Clemson

Megan

Comfort Suites Greenville Airport

Greenville

Reva

₩154,375 total

includes taxes & fees

Mar 15 - Mar 16

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Annisha

₩184,704 total

includes taxes & fees

Mar 1 - Mar 2

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Vacation Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Excellent stay."

Cottage

Lake Access & Boat Slip: Greenwood Cottage!

Greenwood

"Outstanding little cottage for my mom and daughter weekend! Super clean and comfortable. "

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Spotless wonderful stay"

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Room was very clean and welcoming. The only staff we met was Mark, and he was absolutely wonderful and friendly. "

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Lake "

Cottage

Wooded Cottage - 3 Mi to Clemson University

Clemson

Vacation Home

Family House, 4 Bedrooms, Patio, Courtyard View | Private kitchen | Fridge, microwave, oven, stovetop

Belvedere

Anderson

"Bring everything. Including hangers for your clothes, salt and pepper, etc. it is like staying at a place that has one purpose, to rent out. Beds are uncomfortable. Nice big closets with one wire hanger. Why??? "

Cottage

Stunning Lakefront Retreat w/ Dock Access!

Greenwood

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

Cottage

Waterfront Lake Hartwell Vacation Rental w/ Dock!

Townville

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

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Stay near popular Southeastern United States attractions

Clemson University

4.7/5 (738 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Falls Park on the Reedy

4.7/5 (1,399 reviews)

Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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Learn more about Upstate South Carolina

Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.

See all hotels in Upstate South Carolina

It is only a 1 mile hike to this beauty. View a video about it here: https://www.hdcarolina.com/episode/riley-moore-falls

#Waterfall

Top Upstate South Carolina Hotel Reviews

Hotel Hartness

10/10 Excellent

"The room was really clean, staff very helpful and friendly. The hotel itself was really beautiful. Fitness center had nice equipment (only wish they also had a fan!) but it was well air-conditioned. Illy coffee/espresso in the room - was a plus! Really nice looking restaurant within a quick stroll from restaurant that we would have loved to check out if we had more time. Would stay again in a heartbeat and have recommended to family/friends already! "