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Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.4/10 Exceptional! (1,005 reviews)

As always it was a perfect visit

Reviewed on Jan 19, 2026

Pear Tree Inn Sikeston

2602 E Malone Avenue Sikeston MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...

9.2/10 Wonderful! (1,001 reviews)

Clean room. Nice facilities. Pool is half inside half outside so even though it was heated it was still very cold

Reviewed on Jan 19, 2026

Best Western Plus Sikeston

120 S Interstate Drive Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...

8.2/10 Very Good! (1,002 reviews)

Clean and well-kept

Reviewed on Jan 19, 2026

See all 622 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.