Southeast Missouri Pet-friendly Vacations

Book a Pet-friendly Hotel + Flight or Car together to unlock savings

Photo by JG Morris
  • Plan, book, travel with confidence

  • Better together

    Save up to ₩1,660,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Top Pet-friendly Southeast Missouri Hotels

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
  • 2 hours drive from Johnson's Shut-ins State Park
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,003 reviews)
"Room was clean, staff were friendly. The bench in the gazebo was broke but we didn't use that area I just saw it. There were some loud guests with kids running around at midnight but that can happen at any hotel. My recommendation would be more than two pillows per bed. This is our second year staying ..."

Reviewed on Jun 27, 2026

Motel 6 Poplar Bluff, MO
Microtel Inn & Suites by Wyndham Sainte Genevieve

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 out of 5
21958 Hwy 32 Ste Genevieve MO
  • 3 hours drive from Johnson's Shut-ins State Park
Book a stay at this business-friendly hotel in Ste Genevieve. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
8.8/10 Excellent! (648 reviews)
"There were absolutely No ammenties. Bed was not a king. And very uncomfortable"

Reviewed on Jun 29, 2026

Microtel Inn & Suites by Wyndham Sainte Genevieve
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
  • 2 hours drive from Johnson's Shut-ins State Park
This hotel is pet-friendly, allowing dogs and cats with an additional fee. If you're going for a walk during your stay, swing by nearby Jorkerst Memorial ...
7.8/10 Good! (1,005 reviews)
"The elevator broke and we were on the 3rd floor, the bathrooms were dirty and poorly kept, the rooms smelled moldy, when asked if they had any soda for sale the guest service lady said if there’s any in the machine that all we have. The holiday Inn Express is right across the bridge and we stayed ..."

Reviewed on Jun 27, 2026

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.