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Top Pet-friendly Southeast Missouri Hotels

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

3 hours drive from Mark Twain National Forest

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...

7.8/10 Good! (1,001 reviews)

Clean room and helpful staff

Reviewed on Oct 29, 2025

Microtel Inn & Suites by Wyndham Sainte Genevieve

21958 Hwy 32, Ste Genevieve, MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Ste Genevieve. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

8.6/10 Excellent! (603 reviews)

Good stay

Reviewed on Oct 31, 2025

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

1001 Veterans Blvd, Festus, MO

3 hours drive from Mark Twain National Forest

This hotel is pet-friendly, allowing dogs and cats with an additional fee. If you're going for a walk during your stay, swing by nearby Jorkerst Memorial ...

7.8/10 Good! (872 reviews)

The room was very clean. Front desk was accommodating to my last minute check-in and request for a 1st floor room. Upon getting breakfast the gentlemen greeting me while cleaning the tables made polite conversation. Every time you entered the lobby someone was greeting you or cleaning something. ...

Reviewed on Nov 3, 2025

See all 605 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.