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Top Pet-friendly Southeast Missouri Hotels

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

2 hours drive from Johnson's Shut-ins State Park

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...

8/10 Very Good! (1,003 reviews)

"Room was clean, staff were friendly. The bench in the gazebo was broke but we didn't use that area I just saw it. There were some loud guests with kids running around at midnight but that can happen at any hotel. My recommendation would be more than two pillows per bed. This is our second year staying ..."

Reviewed on Jun 27, 2026

Microtel Inn & Suites by Wyndham Sainte Genevieve

21958 Hwy 32 Ste Genevieve MO

3 hours drive from Johnson's Shut-ins State Park

Book a stay at this business-friendly hotel in Ste Genevieve. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

8.8/10 Excellent! (648 reviews)

"There were absolutely No ammenties. Bed was not a king. And very uncomfortable"

Reviewed on Jun 29, 2026

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

1001 Veterans Blvd Festus MO

2 hours drive from Johnson's Shut-ins State Park

This hotel is pet-friendly, allowing dogs and cats with an additional fee. If you're going for a walk during your stay, swing by nearby Jorkerst Memorial ...

7.8/10 Good! (1,005 reviews)

"The elevator broke and we were on the 3rd floor, the bathrooms were dirty and poorly kept, the rooms smelled moldy, when asked if they had any soda for sale the guest service lady said if there’s any in the machine that all we have. The holiday Inn Express is right across the bridge and we stayed ..."

Reviewed on Jun 27, 2026

See all 672 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.