Photo by Sara Crotts

Plan, book, travel with confidence
Better together
Save up to ₩234,741 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Pet-friendly Southeast Minnesota Hotels

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

4353 Canal Pl SE Rochester MN

11 min drive from Mayo Clinic

Make it a pet-friendly trip and bring along your four-legged friend. Dogs are welcome (fees apply) at this suburban hotel.

7.2/10 Good! (1,020 reviews)

I have stayed here a couple times in the past. The renovations are spot on. The cleanliness was superb. The staff were very friendly. The roll in shower and hearing impaired room worked out great for my health issues. It was an easy check in online.

Reviewed on Dec 8, 2025

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Dogs are welcome to join you (fees apply) for a pet-friendly getaway at this family-friendly, city-center motel.

7.8/10 Good! (1,009 reviews)

I arrived late at night and the young man checking me in was most helpful and friendly (don't always see this at 11 pm!) Very clean and comfortable room, even including a selection of different thicknesses of pillows! (A bonus for those of us who don't like sleeping with our head a foot up in the ...

Reviewed on Dec 7, 2025

Spark by Hilton Rochester South

4165 Maine Ave SE Rochester MN

10 min drive from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

9.2/10 Wonderful! (301 reviews)

Not quite what I expected with the excellent rating it had. Once again there were long hair strands on the counter, in the tub and on the floor. There is no in room coffee! When you come in to register you are greeted with a sign and a phone that says "dial zero for attendant", really makes you feel ...

Reviewed on Dec 6, 2025

See all 933 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.