Southeast Minnesota Vacations

Book a Hotel + Flight or Car together to unlock savings

Photo by Chad Johnson

  • Plan, book, travel with confidence

  • Better together

    Save up to ₩234,741 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Southeast Minnesota

Find the best Southeast Minnesota areas and neighborhoods for the activities you enjoy most. Learn more about Southeast Minnesota
Rochester showing skyline and a city

Downtown Rochester

2 out of top 10 points of interest in this area
4.5/5(250 area reviews)

If you're spending some time in Downtown Rochester, Mayo Civic Center and Rochester Civic Theater are top sights worth seeing.

Find hotels in Downtown Rochester

Find the Best Southeast Minnesota Vacation Packages

Southeast Minnesota Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
The price is ₩162,771 per night from Dec 12 to Dec 13
₩162,771
₩187,384 total
Dec 12 - Dec 13
includes taxes & fees
8.2/10 Very Good! (1,782 reviews)
Construction

Reviewed on Nov 27, 2025

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
The price is ₩158,676 per night from Dec 6 to Dec 7
₩158,676
₩182,675 total
Dec 6 - Dec 7
includes taxes & fees
7.8/10 Good! (1,519 reviews)
I was at Methodist Hospital and great for people that need to visit there. Convenient

Reviewed on Nov 27, 2025

Kahler Inn and Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
The price is ₩105,806 per night from Dec 21 to Dec 22
₩105,806
₩121,809 total
Dec 21 - Dec 22
includes taxes & fees
7.8/10 Good! (1,012 reviews)
Staff was super helpful, great breakfast, shirt drive to Mayo

Reviewed on Nov 24, 2025

Med City Inn & Suites - Mayo Clinic Area
See all 931 properties in Southeast Minnesota
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southeast Minnesota

Mayo Clinic Hospital - Saint Marys Campus

Though Mayo Clinic Hospital - Saint Marys Campus might be what brings you to town, perhaps you'll have a chance to explore more of Rochester while you are here.

Mayo Clinic Hospital - Saint Marys Campus

Frequently asked questions

Can I cancel my flight booking to Southeast Minnesota due to COVID-19?
Head to our Customer Service Portal for important info about changing your flights due to COVID-19. Make sure you also read through the terms and conditions of your chosen carrier before booking your seat.
What's the best way to find cheap flights to Southeast Minnesota that have flexible change policies?
It's as easy as counting to three with Expedia. Firstly, enter your preferred dates and destination and click on the "Search" button. Second step: Check "No change fee" below the "Flexible change policies" subheading on the left-hand side of your screen. Step 3. Snag a cheap and flexible ticket to Southeast Minnesota.
What are some of the general tips for travelers to Southeast Minnesota during the COVID-19 outbreak?
The COVID-19 pandemic has ushered in major changes to how we travel. If you're planning a trip to Southeast Minnesota, these tips will help you navigate this new traveling reality:
  • Investigate what, if any, rules or restrictions apply to both your origin and destination. You may not be able to travel depending on local circumstances, so don't forget to check before you lock something in.
  • Keep your face mask on during airport screening. A TSA officer will ask you to adjust your mask to verify your identity.
  • To reduce the potential of cross-contamination, place your boarding pass on the reader yourself and then hold it up for inspection. Do not hand your boarding pass directly to a TSA agent.
  • You are now allowed to take one container of hand sanitizer up to 12 oz (350 ml) in your hand luggage. You'll need to remove it for screening.
  • To reduce handling during screening, place items such as your phone, coins and keys into your carry-on instead of the bins.
  • If you want to take food on the plane, put it in a clear plastic bag and then into a scanning bin. This lessens the likelihood that a TSA officer will need to handle your food container or carry-on bag for closer inspection.

Which airlines fly to Southeast Minnesota?
Delta is a top carrier servicing Southeast Minnesota. Look up airfares to Minneapolis - St. Paul Intl. Airport (MSP) and you'll have 10082 Delta flights a month to select from.
How can I find cheap tickets to Southeast Minnesota?
In the last seven days, was the lowest price for a flight to Southeast Minnesota. For even greater savings, book in advance and be flexible with your dates. Search for your flight to Southeast Minnesota, then see prices for nearby days by clicking on our "flexible dates" link.
How much is a flight to Southeast Minnesota?
One-way flights from () sold for just in the last seven days. During this time, the cost of a return ticket to Southeast Minnesota varied between and . If you spot a deal, book fast — these fares don't wait around for long.
What are the most popular airports to fly into in Southeast Minnesota?
Jet into Minneapolis - St. Paul Intl. Airport (MSP) and experience everything that Southeast Minnesota has to offer. As the region's main point of entry, roughly 13006 flights touch down here each month.
When is the cheapest time to fly to Southeast Minnesota?
If you're not fixed on your travel dates to Southeast Minnesota, fly out early in the week. The most affordable day to take off is generally Tuesday, closely followed by Monday. Saturday is typically the priciest day, with a lot of people opting to take off on the weekend.
How much is a plane ticket to Southeast Minnesota?
Seats ranged from just to over the last seven days. When you're ready to book, we'll help you find the best deal to Southeast Minnesota.
Which airlines with flights to Southeast Minnesota employ COVID-19 cleanliness policies?
To help minimize contact between travelers and flight crew during the ongoing COVID-19 pandemic, airlines have taken social distancing and other preventive measures to the skies. An example of these are:
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.
  • Sun Country Airlines - this airline is known for electrostatic cleaning and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.