Find hotels near Mayo Clinic, Rochester from ₩109,943

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Our top choices for Mayo Clinic hotels

Property amenity
TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area
3.0 star property
Downtown Rochester, 0.4 km from Mayo Clinic
9.6 out of 10, Exceptional, (481)
"Room was large, clean, beds were comfortable. Downstairs cafe and seating areas were very comfortable."
United States
Ann
The price is ₩174,201
₩200,549 total
includes taxes & fees
Dec 26 - Dec 27
TownePlace Suites by Marriott Rochester Mayo Clinic Area
Lobby
Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
3.5 star property
Downtown Rochester, 0.3 km from Mayo Clinic
9.6 out of 10, Exceptional, (545)
"Very courteous staff, loved the valet guy!"
United States
Jean
The price is ₩253,005
₩291,272 total
includes taxes & fees
Dec 26 - Dec 27
Hilton Rochester Mayo Clinic Area
View from property
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
2.5 star property
Kutzky Park, 1.8 km from Mayo Clinic
9.6 out of 10, Exceptional, (677)
"Good place to stay when traveling to Mayo apots"
United States
Carolyn
The price is ₩131,389
₩151,261 total
includes taxes & fees
Dec 25 - Dec 26
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
Terrace/patio
The Berkman

The Berkman

The Berkman
3.0 star property
Folwell, 1.4 km from Mayo Clinic
9.6 out of 10, Exceptional, (371)
"Staff was great, as was the room."
United States
Scott
The price is ₩205,941
₩239,467 total
includes taxes & fees
Dec 24 - Dec 25
The Berkman
Terrace/patio
Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
3.0 star property
2.6 km from Mayo Clinic
9.6 out of 10, Exceptional, (881)
"Great stay,clean and friendly"
United States
Janet
The price is ₩168,266
₩193,716 total
includes taxes & fees
Dec 26 - Dec 27
Home2 Suites by Hilton Rochester Mayo Clinic Area
BBQ/picnic area
Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South
3.0 star property
2.6 km from Mayo Clinic
9.6 out of 10, Exceptional, (249)
"Very nice motel "
United States
Jim
The price is ₩188,964
₩217,545 total
includes taxes & fees
Dec 24 - Dec 25
Residence Inn by Marriott Rochester Mayo Clinic Area South
Courtyard
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park, 1 km from Mayo Clinic
9.4 out of 10, Exceptional, (962)
"Rooms are comfortable and staff was was so professional and helpful."
United States
William
The price is ₩143,169
₩167,779 total
includes taxes & fees
Dec 21 - Dec 22
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Courtyard
Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG
3.0 star property
Kutzky Park, 1 km from Mayo Clinic
9.4 out of 10, Exceptional, (421)
"Early check in was definitely a plus since I flew from out of town. "
United States
Humberto
The price is ₩162,007
₩189,465 total
includes taxes & fees
Dec 21 - Dec 22
Staybridge Suites Rochester - Mayo Clinic Area by IHG
Terrace/patio
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester, 0.5 km from Mayo Clinic
9.2 out of 10, Wonderful, (1003)
"Quick and easy check-in, walkable area and nice breakfast and accomodations. Would stay again!"
United States
Elizabeth
The price is ₩190,440
₩219,244 total
includes taxes & fees
Dec 23 - Dec 24
Hyatt House Rochester/Mayo Clinic Area
Fridge, microwave, oven, stovetop
Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham
3.0 star property
Downtown Rochester, 0.3 km from Mayo Clinic
9.2 out of 10, Wonderful, (167)
"Great staff, clean room, spacious kitchen and living room."
United States
silvia
The price is ₩211,256
₩243,208 total
includes taxes & fees
Dec 26 - Dec 27
Broadway Plaza, Trademark Collection by Wyndham
Exterior
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park, 1.4 km from Mayo Clinic
9.2 out of 10, Wonderful, (769)
"Clean room and housekeeping service was excellent"
United States
Dawn
The price is ₩124,008
₩142,764 total
includes taxes & fees
Dec 24 - Dec 25
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Terrace/patio
Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
3.0 star property
Kutzky Park, 1.4 km from Mayo Clinic
9.2 out of 10, Wonderful, (477)
"Clean room, breakfast selection"
United States
Sonya
The price is ₩144,055
₩165,843 total
includes taxes & fees
Dec 28 - Dec 29
Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
Exterior
Candlewood Suites Rochester Mayo Clinic Area by IHG

Candlewood Suites Rochester Mayo Clinic Area by IHG

Candlewood Suites Rochester Mayo Clinic Area by IHG
2.5 star property
2.6 km from Mayo Clinic
9.2 out of 10, Wonderful, (452)
"The staff checking in and out were helpful and friendly. The room was clean, comfortable, and quiet. "
United States
Allison
The price is ₩143,199
₩164,858 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Candlewood Suites Rochester Mayo Clinic Area by IHG
Front of property
Aspen Suites

Aspen Suites

Aspen Suites
3.0 star property
1.2 km from Mayo Clinic
9.0 out of 10, Wonderful, (693)
"Room was clean and inviting and staff always willing to help"
United States
Maria del Carmen
The price is ₩236,190
₩285,513 total
includes taxes & fees
Jan 16 - Jan 17, 2026
Aspen Suites
Terrace/patio
Hampton Inn Rochester-South

Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
2.9 km from Mayo Clinic
9.0 out of 10, Wonderful, (1007)
"We had a wonderful stay!"
United States
Sarah
The price is ₩121,542
₩139,925 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn Rochester-South
Free daily full breakfast
Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
3 km from Mayo Clinic
9.0 out of 10, Wonderful, (897)
"Good breakfast..shuttle service is excellent..super nice staff.."
United States
DALE K
The price is ₩97,065
₩111,746 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Econo Lodge Mayo Clinic Area
Exterior
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester, 0.3 km from Mayo Clinic
8.8 out of 10, Excellent, (891)
"Room was clean and comfortable Staff courteous Comfortable beds Great restaurant"
United States
Matney
The price is ₩118,102
₩135,965 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Desk, iron/ironing board, free WiFi, bed sheets
Brentwood Inn & Suites

Brentwood Inn & Suites

Brentwood Inn & Suites
2.5 star property
Downtown Rochester, 0.3 km from Mayo Clinic
8.8 out of 10, Excellent, (1003)
"Convenient, clean location and friendly staff"
United States
Kaushika
The price is ₩166,082
₩191,194 total
includes taxes & fees
Dec 21 - Dec 22
Brentwood Inn & Suites
Breakfast served
Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester, 0.3 km from Mayo Clinic
8.8 out of 10, Excellent, (853)
"Everything was wonderful! Helpful, friendly staff, great location, nice amenities."
United States
kristi
The price is ₩158,006
₩181,904 total
includes taxes & fees
Dec 26 - Dec 27
Hilton Garden Inn Rochester Downtown, MN
Free daily full breakfast
Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area
2.5 star property
2.6 km from Mayo Clinic
8.8 out of 10, Excellent, (830)
"Very clean and so helpful "
United States
Mark
The price is ₩94,113
₩109,943 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Quality Inn & Suites Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mayo Clinic Hotel Reviews

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent
"Very clean and fresh "
Joan 1-night trip
Posted 3 days ago
EVEN Hotel Rochester - Mayo Clinic Area by IHG

Hotels near other Mayo Clinic attractions

Soldiers Field Veterans Memorial

4.5/5 (30 reviews)
You can learn about the history of Rochester with a visit to Soldiers Field Veterans Memorial. Attend a sporting event or simply visit the area's shops.
See properties

Plummer Building

You can find out about the history of Rochester when you stop by Plummer Building.
See properties

Frequently asked questions

What's the area like around Mayo Clinic?
Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 157 hotels and other accommodations you'll find within a mile.
What's the best place to stay close to Mayo Clinic?
Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Hyatt House Rochester/Mayo Clinic Area.
How many hotels will I be able to find near Mayo Clinic?
Expedia has 157 hotels and other accommodations within a mile from Mayo Clinic.
If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?
Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near Mayo Clinic.
Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?
For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.
What can I see and do near Mayo Clinic?
You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Assisi Heights and Plummer House. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.