The Best Hotels Closest to Mayo Clinic in Rochester for 2026

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Our top choices for Mayo Clinic hotels

A modern living room with a flat-screen TV, a fireplace, comfortable seating, and a large window with a city view.

A modern hotel lobby with a curved staircase, seating areas, and large windows.

A modern hotel entrance with a glass facade, illuminated signage, and a covered walkway.

A spacious lobby with modern furniture, a spiral staircase, and large windows offering views of the outdoors.

1. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Raymond

₩246,698

₩284,011 total

includes taxes & fees

Oct 17 - Oct 18

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel room with a bed, bedside table, and a window with curtains.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

2. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Hafsa

₩185,676

₩213,760 total

includes taxes & fees

Oct 23 - Oct 24

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern lounge area with a sofa, chairs, and tables.

A modern hotel room with a bed, desk, and kitchenette.

3. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

Vickie

₩167,474

₩192,805 total

includes taxes & fees

Oct 24 - Oct 25

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A modern interior with a large dining table, sofas, and a kitchen area.

An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

4. The Berkman

Folwell, 1.4 km from Mayo Clinic

Kathleen

₩231,202

₩268,815 total

includes taxes & fees

Sep 25 - Sep 26

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern lounge area with seating, a fireplace, and a bar area.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Chee

₩181,335

₩208,762 total

includes taxes & fees

Oct 2 - Oct 3

A modern indoor patio with a fire feature, seating, and large windows.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Brooke

₩159,925

₩202,427 total

includes taxes & fees

Oct 23 - Oct 24

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

A hotel room with a kitchenette, a bed, a sofa, a small table, and a window with curtains.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

matthew

₩152,486

₩178,297 total

includes taxes & fees

Oct 2 - Oct 3

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

A person at a checkout counter in a store, with various snack items and a sign indicating a price of $1.50.

A sign instructing to clean up after dogs and dispose of waste, with a Poopy Pouch attached.

An outdoor patio with a stone wall, a grill, and seating.

8. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Sean

₩159,355

₩183,457 total

includes taxes & fees

Sep 25 - Sep 26

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A conference room with a long table, multiple chairs, and decorative wall art.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

A modern living room with a sofa, a round coffee table, and a side table. There are large windows with a view of the outside.

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

MATTHEW

₩177,214

₩204,030 total

includes taxes & fees

Sep 26 - Sep 27

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

An indoor swimming pool with a clock on the wall, lounge chairs, and a lifeguard warning sign.

A multi-story building with the sign 'Broadway Plaza' indicating a commercial or hotel property.

10. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 0.3 km from Mayo Clinic

Anita

₩229,249

₩263,923 total

includes taxes & fees

Oct 17 - Oct 18

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

A conference room with multiple tables and chairs, ceiling fans, and artwork on the walls.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

A modern hotel lobby with a stone wall fireplace, comfortable seating, and a chandelier.

11. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

Lin

₩154,477

₩177,842 total

includes taxes & fees

Oct 3 - Oct 4

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern bar area with seating and a counter.

A modern indoor pool area with lounge chairs and a pool.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

12. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Kathy

₩159,925

₩184,115 total

includes taxes & fees

Oct 17 - Oct 18

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

13. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

dennis

₩143,364

₩165,047 total

includes taxes & fees

Oct 18 - Oct 19

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

14. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

Ashley

₩102,190

₩117,645 total

includes taxes & fees

Oct 18 - Oct 19

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A reception area with a curved counter, ceiling lights, and a potted plant.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

15. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Daniel

₩127,059

₩146,277 total

includes taxes & fees

Sep 25 - Sep 26

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

An outdoor patio area with brick walls, a large arched window, and outdoor seating.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

A hotel entrance with a prominent Aspen sign, a large brick building in the background, and a clear sky.

16. Aspen Suites

1.2 km from Mayo Clinic

Dana

₩194,564

₩235,200 total

includes taxes & fees

Oct 2 - Oct 3

An outdoor dining area with wooden beams, tables, and chairs.

A hotel room with a bed, a desk, a chair, a television, and artwork on the walls.

A hotel room with a bed, a desk, a chair, a TV, and artwork on the walls.

A modern kitchen with a built-in microwave, refrigerator, and dark cabinetry.

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

thomas

₩139,596

₩160,710 total

includes taxes & fees

Oct 24 - Oct 25

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A spacious lobby with a large seating area, a fireplace, and large windows providing natural light.

18. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

John

₩154,477

₩177,842 total

includes taxes & fees

Oct 23 - Oct 24

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

19. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

Edward

₩103,680

₩120,826 total

includes taxes & fees

Oct 18 - Oct 19

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A garden with a water feature, rocks, and yellow umbrellas.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A restaurant interior with wooden tables, chairs, and a stone wall.

20. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest, 0.6 km from Mayo Clinic

Carrie

₩146,178

₩168,288 total

includes taxes & fees

Oct 6 - Oct 7

View all properties

Compare popular hotels close to Mayo Clinic

Property	Property class	Guest rating
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 647 reviews	View
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 562 reviews	View
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,004 reviews	View
The Berkman	9.6 Exceptional 439 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 309 reviews	View

Top Mayo Clinic Hotel Reviews

Med City Inn & Suites - Mayo Clinic Area

8/10 Good

"Staff very good"

AmericInn by Wyndham Rochester Near Mayo Clinic

10/10 Excellent

"Easy shuttle access to Mayo, At. Mary's appointments"

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"We enjoyed our stay. The breakfast was wonderful. We were disappointed the hot tub only ran for the first evening though and was down for maintenance after. And the exercise room was a bit grimy"

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Enjoyed my stay Will return"

Hilton Garden Inn Rochester Downtown, MN

8/10 Good

"The staff are very friendly and helpful! They have valet parking and shuttle buses to both Mayo Clinic and St Mary’s, so I only needed to pay for valet while I went to both locations. This service was even available at 4 am, when I needed a ride back from the ER at St Mary’s! Otherwise, they put my room facing the parking lot so it was quieter. Also, I overslept the check out time, so the cleaning staff gave me extra time to get ready and the front desk didn’t charge me extra for the late checkout. I’d recommend this place for the staff alone, but the hotel and room were great, too! Clean, access to the skyway system, close to Mayo Clinic, and a hot breakfast with pancakes to order! The room had what I needed to work remotely, pillows that didn’t trigger an allergic reaction, and panel-controlled heat/AC."

Brentwood Inn & Suites

8/10 Good

"Easy shuttle service to Mayo Clinic."

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Very nice hotel and well maintained!"

TownePlace Suites by Marriott Rochester Mayo Clinic Area

8/10 Good

"Lovely spot and spaces. Rooms large and more than adequate, Only negative was that the rooms smelled a little "moldy.""

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

10/10 Excellent

"Was there for a surgery at the Mayo and they were so helpful and accommodating. Very grateful for the facility and the staff"

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 153 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels will I be able to find near Mayo Clinic?

Expedia has 153 hotels and other accommodations within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near Mayo Clinic.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?

For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Plummer House and Assisi Heights. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Find hotels near Mayo Clinic, Rochester from ₩117,645

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Our top choices for Mayo Clinic hotels

1. Hilton Rochester Mayo Clinic Area

2. TownePlace Suites by Marriott Rochester Mayo Clinic Area

3. Home2 Suites by Hilton Rochester Mayo Clinic Area

4. The Berkman

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

8. Candlewood Suites Rochester Mayo Clinic Area by IHG

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

10. Broadway Plaza, Trademark Collection by Wyndham

11. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

12. Hyatt House Rochester/Mayo Clinic Area

13. Hampton Inn Rochester-South

14. Econo Lodge Mayo Clinic Area

15. Brentwood Inn & Suites

16. Aspen Suites

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

18. Hilton Garden Inn Rochester Downtown, MN

19. Quality Inn & Suites Mayo Clinic Area

20. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

Med City Inn & Suites - Mayo Clinic Area

AmericInn by Wyndham Rochester Near Mayo Clinic

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Hyatt House Rochester/Mayo Clinic Area

Hilton Garden Inn Rochester Downtown, MN

Brentwood Inn & Suites

Staybridge Suites Rochester - Mayo Clinic Area by IHG

TownePlace Suites by Marriott Rochester Mayo Clinic Area

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Frequently asked questions