Photo by Southernmost Illinois Tourism Bureau

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Top Adventure Southwest Illinois Hotels

SureStay Hotel by Best Western Whittington Rend Lake

13277 Freeway Lane Whittington IL

1 hour drive from Southern Illinois University

Book a stay at this business-friendly hotel in Whittington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

8.8/10 Excellent! (933 reviews)

Friendly service clean comfortable rooms nice stay and excellent price.

Reviewed on Feb 24, 2026

Hampton Inn Carbondale

2175 Reed Station Pkwy Carbondale IL

10 min drive from Southern Illinois University

Book a stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

8.4/10 Very Good! (625 reviews)

Clean Room, Friendly Staff

Reviewed on Mar 4, 2026

Days Inn & Suites by Wyndham Caseyville

2423 Old Country Inn Drive Caseyville IL

3 hours drive from Southern Illinois University

Book a stay at this business-friendly hotel in Caseyville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pleasant Ridge Park and Cahokia ...

4/10 (342 reviews)

No hot water, no blankets, no towels, no tv reception. Just an overall bad experience for a Days Inn. Will not return

Reviewed on Mar 9, 2026

See all 746 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.