Photo by Southernmost Illinois Tourism Bureau

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Top Adventure Southwest Illinois Hotels

SureStay Hotel by Best Western Whittington Rend Lake

13277 Freeway Lane Whittington IL

1 hour drive from Southern Illinois University

Book a stay at this business-friendly hotel in Whittington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

8.8/10 Excellent! (964 reviews)

"The lady at the counter was very nice and went over and above to get me something to eat during a tornado warning and pouring rain"

Reviewed on May 20, 2026

Hampton Inn Carbondale

2175 Reed Station Pkwy Carbondale IL

10 min drive from Southern Illinois University

Book a stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

8.4/10 Very Good! (642 reviews)

"The room was very clean. Very warm when we entered but was easily adjustable. Everyone on the staff was friendly and helpful. That says alot about the the community, city, and local university."

Reviewed on May 7, 2026

Days Inn & Suites by Wyndham Caseyville

2423 Old Country Inn Drive Caseyville IL

3 hours drive from Southern Illinois University

Book a stay at this business-friendly hotel in Caseyville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pleasant Ridge Park and Cahokia ...

4/10 (347 reviews)

"These folks are trying"

Reviewed on May 20, 2026

See all 764 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.