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Top Luxury Southeastern Indiana Hotels

21c Museum Hotel Louisville

700 W Main Street Louisville KY

9 min walk from KFC Yum Center

21c Museum Hotel Louisville is one of the Louisville luxury 4.5-star boutique properties where you can treat yourself to Champagne service, massage services, ...

9.4/10 Exceptional! (1,000 reviews)

Great staff and a wonderful lobby experience. Room was spacious and clean. Restaurant and bar were both very good.

Reviewed on Mar 19, 2026

The Brown Hotel

335 W Broadway Louisville KY

14 min walk from KFC Yum Center

The Brown Hotel is a Louisville luxury 4.5-star boutique property where you can pamper yourself with Egyptian cotton sheets, plush bedding, and more. The restaurant, ...

9.4/10 Exceptional! (1,182 reviews)

Luxurious historic hotel. Everything is top notch and updated. Even the elevator is incredibly fast. Beautiful rooms.

Reviewed on Mar 25, 2026

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

3 min walk from KFC Yum Center

Go for a luxurious stay at Galt House Hotel Trademark Collection by Wyndham, where you can enjoy amenities like massage services, premium channels, and more. ...

9/10 Wonderful! (4,091 reviews)

It was fine.

Reviewed on Mar 24, 2026

See all 1,165 properties in Southeastern Indiana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.