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Compare 275 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Santa Cruz hotels

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 star property
9.2 out of 10, Wonderful, (248)
"Nice hotel "
The price is ₩131,005
₩131,005 total
Aug 31 - Sep 1
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Sun Hotel

3.5 star property
8.2 out of 10, Very Good, (313)
"Todo excelente "
The price is ₩135,464
₩135,464 total
Aug 29 - Aug 30
Sun Hotel

TRYP by Wyndham Santa Cruz

4.0 star property
9.2 out of 10, Wonderful, (131)
"Nice stay with good service "
The price is ₩151,910
₩151,910 total
Aug 29 - Aug 30
TRYP by Wyndham Santa Cruz

Hotel LP Santa Cruz Centro

3.0 star property
8.0 out of 10, Very Good, (280)
"Clean, friendly staff"
The price is ₩61,685
₩61,685 total
Sep 6 - Sep 7
Hotel LP Santa Cruz Centro

Terranova Suites

3.5 star property
8.0 out of 10, Very Good, (90)
"The pictures of the property have to be from a decade ago. This place it is dirty and in poor shape. "
The price is ₩67,945
₩67,945 total
Sep 1 - Sep 2
Terranova Suites

Novotel Santa Cruz De La Sierra

5.0 star property
9.2 out of 10, Wonderful, (95)
"Nice hotel, modern, with pool, good restaurant. Would stay here again without no doubt. "
The price is ₩146,335
₩146,335 total
Sep 26 - Sep 27
Novotel Santa Cruz De La Sierra

Hotel Continental Park

3.0 star property
8.6 out of 10, Excellent, (24)
The price is ₩95,954
₩95,954 total
Aug 29 - Aug 30
Hotel Continental Park

Cosmopolitano Hotel Boutique

3.5 star property
9.2 out of 10, Wonderful, (121)
"Top class and 5 Stars. Attentive , caring staff and wonderful food ! A great location, only 10 minutes from 24 Septiembre plaza. Thoroughly recommend."
The price is ₩108,710
₩108,710 total
Aug 29 - Aug 30
Cosmopolitano Hotel Boutique

Hotel G

3.5 star property
7.8 out of 10, Good, (104)
"Excelente Hotel "
The price is ₩67,227
₩67,227 total
Aug 29 - Aug 30
Hotel G

Alfonsina Hotel Boutique by Inboccaluppo

3.5 star property
9.4 out of 10, Exceptional, (38)
"Love it. Will stay again!!"
The price is ₩186,577
₩186,577 total
Aug 29 - Aug 30
Alfonsina Hotel Boutique by Inboccaluppo

Premium Suites Deluxe Aparthotel Equipetrol

3.5 star property
9.0 out of 10, Wonderful, (73)
"Good price, great hotel!"
The price is ₩66,855
₩66,855 total
Aug 29 - Aug 30
Premium Suites Deluxe Aparthotel Equipetrol

Swissôtel Santa Cruz De La Sierra

4.5 star property
9.2 out of 10, Wonderful, (77)
"Beautiful hotel"
The price is ₩206,263
₩206,263 total
Sep 11 - Sep 12
Swissôtel Santa Cruz De La Sierra

Apart Hotel Premium Suites Santa Cruz

3.5 star property
8.6 out of 10, Excellent, (91)
"Come and go easily, intellectual and kind owners who are working hard to make the property improvements that will bring this hotel up to the next level. A family friendly environment with easy walking distance to everything you need. Bed was not the best, but I know they are upgrading so I appreciate the ongoing process. For a few nights stay, the deals are very fair prices. "
The price is ₩37,629
₩37,629 total
Aug 29 - Aug 30
Apart Hotel Premium Suites Santa Cruz

Casa Vida

3.5 star property
9.0 out of 10, Wonderful, (2)
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"
The price is ₩131,701
₩131,701 total
Aug 29 - Aug 30
Casa Vida

Buganvillas Hotel Suites & Spa

4.0 star property
7.4 out of 10, Good, (92)
"Gammelt og veldig slitt og skittent. Det var et fint hotell for 20 år siden. Men ikke vedlikeholdt. "
The price is ₩62,716
₩62,716 total
Aug 29 - Aug 30
Buganvillas Hotel Suites & Spa

Hotel Arenal

3.5 star property
7.6 out of 10, Good, (58)
"Perfect hotel in a central location!"
The price is ₩87,676
₩87,676 total
Aug 29 - Aug 30
Hotel Arenal

Equipetrol Suites Apart Hotel

2.5 star property
8.4 out of 10, Very Good, (7)
"Perfect hotel"
The price is ₩56,443
₩56,443 total
Aug 30 - Aug 31
Equipetrol Suites Apart Hotel

Chairú Eco Hotel

3.5 star property
9.4 out of 10, Exceptional, (39)
"Nice and clean hotel "
The price is ₩71,245
₩71,245 total
Aug 29 - Aug 30
Chairú Eco Hotel

Camino Real Hotel

4.5 star property
8.8 out of 10, Excellent, (397)
"Great Hotel, had a great time ."
The price is ₩193,999
₩193,999 total
Aug 31 - Sep 1
Camino Real Hotel

Hotel LP Equipetrol

3.5 star property
8.2 out of 10, Very Good, (199)
"Nice place to stay"
The price is ₩67,138
₩67,138 total
Sep 3 - Sep 4
Hotel LP Equipetrol
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most.

Hamacas

While Hamacas isn't home to many top sights, Santa Cruz Zoo and Las Brisas Shopping Center are some notable places to visit nearby.

Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

San Lorenzo Cathedral showing a garden

Top Santa Cruz Hotel Reviews

More cheap stays in Santa Cruz

More cheap stays in Santa Cruz

Frequently asked questions

What's the best place for a stay in Santa Cruz?

Ibis Santa Cruz DE LA Sierra is a favorite with Expedia customers. This hotel offers a restaurant and free parking. Reviews from our site also recommend Chairú Eco Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel as top options for your trip. See all available top hotels, or vacation rentals in Santa Cruz.

What's the top vacation rental that Santa Cruz has to offer?

Casa Vida: Visitors give good reviews to this Santa Cruz vacation home rental, which is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a full-sized fridge, a stovetop, and a microwave. Kick off your shoes and enjoy yourself with a private yard and a selection of games. See all vacation rentals in Santa Cruz.

If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?

Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.

Where can I learn more about changing or cancelling my trip to Santa Cruz?

To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.

What's the best budget-friendly accommodation in Santa Cruz?

Based on our traveler reviews, residencial francia - Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include Urubo Suite - Hostel and Residencial Ikandire II. View all budget hotels in Santa Cruz.

What's the best accommodation for a family trip to Santa Cruz?

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a hotel with 2 restaurants and free parking, and it's a top choice on Expedia for families. Other choices for your stay with the kids include Marriott Santa Cruz de la Sierra Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia. Attractions like Santa Cruz Zoo and Play Land Amusement Park are also fun for kids of all ages. Find more child-friendly accommodations in Santa Cruz.

What is the top LGBTQ-friendly accommodation in Santa Cruz?

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santa Cruz.

What's the best pet-friendly hotel in Santa Cruz?

Ibis Santa Cruz DE LA Sierra is a top hotel for people traveling with their pets, and offers a restaurant and free WiFi for its human guests. Other good options for you and your pet's trip include Hotel LP Santa Cruz Centro and Hotel LP Equipetrol. See more pet-friendly hotel accommodations in Santa Cruz.

Where is the best place to stay close to Plaza 24 de Septiembre?

Adjacent to Plaza 24 de Septiembre, Nomad Hostel is one of the top choices for your stay based on our traveler data, and this property offers a restaurant and a bar. Other good options close by include Senses Centro and Cosmopolitano Hotel Boutique.

What about the best place to stay near Ventura Mall?

One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and a restaurant. Los Tajibos Hotel And Convention Center and Marriott Santa Cruz de la Sierra Hotel are two other good choices in the immediate area.

What's the best luxury accommodation in Santa Cruz?

Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia and Camino Real Hotel are other upscale choices for your vacation. Find more luxury hotels in Santa Cruz.

What are some accommodations with pools in Santa Cruz?

Sun Hotel is a top hotel with a children's pool, an outdoor pool, and free buffet breakfast. A couple of other options that offer an onsite pool include Buganvillas Hotel Suites & Spa and Yotau All Suites Hotel. View all hotels with pools in Santa Cruz.

What is the best spa hotel in Santa Cruz?

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a top spa hotel featuring a fitness center, a hair salon, and a bar. Enjoy a facial, body scrub, or hydrotherapy at Los Tajibos Club Spa. Other popular spa hotels in Santa Cruz include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. See all spa hotels in Santa Cruz.

What's the best hotel for staying near Viru Viru International Airport (VVI)?

Sun Hotel is a popular 3.5-star hotel featuring free breakfast and a restaurant. It's located a short 1.3 mi (2.1 km) from Viru Viru Intl. Airport.

How is it to stay in Santa Cruz?

Visitors to Santa Cruz are sure to enjoy the shopping. Tourists can also enjoy the city's cafes, zoo, and cathedral. In Santa Cruz, there are 269 hotels and other accommodations to choose from. Find out more about Santa Cruz.

What should I do while I'm visiting Santa Cruz?

Cultural venues include Cine Center, Sacred Art Museum, and Franco Aleman Cultural Center. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre, and Catedral de Santa Cruz might be worth a visit. The picturesque setting of Guembe Biocenter and Lomas de Arena Regional Park exemplify the area's natural beauty. Check out what more to see and do in Expedia's Santa Cruz guide.

How should I get around Santa Cruz?

To see more of the larger area, ride aboard one of the trains from Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.

What's the weather like in Santa Cruz?

The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.