Find All Southwest Illinois Hotels
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Find All Southwest Illinois Hotels
We have found 680 Southwest Illinois Hotels
- Tru By Hilton Cape Girardeau
- Drury Inn & Suites Sikeston, MO
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Pear Tree Inn Cape Girardeau West
- MainStay Suites St. Louis - Galleria
- Super 8 by Wyndham Staunton
- The Great Rivers, Ascend Hotel Collection
- Microtel Inn & Suites by Wyndham Sainte Genevieve
- Cobblestone Inn & Suites - Altamont
- Harrah's Metropolis Hotel & Casino
- Holiday Inn Express and Suites Alton St Louis Area by IHG
- Economy Inn & Suites
- BEST WAY INN
- Pear Tree Inn Sikeston
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Drury Inn & Suites Cape Girardeau
- Motel 6 Metropolis, IL
- The Last Hotel
- Quality Inn Litchfield Route 66
- Motel 6 Litchfield, IL
- Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
- Historic Red Rooster Inn
Let Expedia take you to the best Hotels in Southwest Illinois. You'll find the largest selection of hotel deals, discount prices, and cheap hotel rates on reservations anywhere in the world. Expedia, the leader in world travel, gives you customer reviews, maps, and the best selection of hotels near landmarks and attractions.