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Discover 4,825 Central San Mateo hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Holiday Inn Hotel & Suites San Mateo-San Francisco SFO by IHG
Holiday Inn Hotel & Suites San Mateo-San Francisco SFO by IHG

Bay Landing San Francisco Airport Hotel
Bay Landing San Francisco Airport Hotel

The Ameswell Hotel
The Ameswell Hotel

Hotel Avante - JDV by Hyatt
Hotel Avante - JDV by Hyatt

Castle Inn
Castle Inn

Hotel G San Francisco
Hotel G San Francisco
Where to stay in Central San Mateo

Fisherman's Wharf
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

Union Square
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Downtown San Francisco
Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

South of Market
From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill
Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.
Recent reviews of Central San Mateo hotels
Recent reviews of Central San Mateo hotels

Chancellor Hotel on Union Square
Explore a world of travel with Expedia
Explore a world of travel with Expedia
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More Accommodation Types in Central San Mateo
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