Find hotels in East Prairie, MO from ₩86,484

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Our top choices for East Prairie hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,001 reviews)
"Great place. Friendly staff clean"
United States
Jeff
The price is ₩130,805
₩150,384 total
includes taxes & fees
Jan 13 - Jan 14
Drury Inn & Suites Sikeston, MO

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (329 reviews)
"The rooms are big and the property is spotless!"
United States
debbie
The price is ₩116,429
₩138,260 total
includes taxes & fees
Jan 15 - Jan 16
Sleep Inn at Discovery Park of America

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,008 reviews)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is ₩97,591
₩111,230 total
includes taxes & fees
Jan 18 - Jan 19
Best Western Plus Sikeston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (728 reviews)
"Clean room and easy access to room"
United States
Anne
The price is ₩80,657
₩91,930 total
includes taxes & fees
Jan 11 - Jan 12
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (550 reviews)
"Roaches!"
United States
Teresa
The price is ₩91,559
₩108,725 total
includes taxes & fees
Jan 11 - Jan 12
Country Hearth Inn & Suites Union City

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (310 reviews)
"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is ₩145,355
₩172,609 total
includes taxes & fees
Feb 7 - Feb 8
Holiday Inn Express & Suites Union City by IHG

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1,001 reviews)
"Very clean, very friendly! We will be staying again. "
United States
Beth
The price is ₩109,002
₩125,311 total
includes taxes & fees
Jan 13 - Jan 14
Pear Tree Inn Sikeston

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (734 reviews)
"Friendly sta"
United States
Melissa
New Orleans Inn Portageville

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (460 reviews)
"Very clean and super friendly staff!"
United States
Katherine
The price is ₩145,500
₩164,741 total
includes taxes & fees
Jan 25 - Jan 26
Hampton Inn Sikeston

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very Good, (490 reviews)
"Nice room"
Mexico
José Ricardo
The price is ₩97,606
₩115,907 total
includes taxes & fees
Feb 1 - Feb 2
Quality Inn Union City US 51

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very Good, (43 reviews)
"Great hotel, great staff"
United States
Dmitry
The price is ₩81,108
₩92,647 total
includes taxes & fees
Jan 20 - Jan 21
Super 8 By Wyndham Marston

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (275 reviews)
"The quality was not what I expected for a "Quality Inn". It felt more light a Motel 6. I was not satisfied at all."
United States
ReShena
The price is ₩103,420
₩114,775 total
includes taxes & fees
Jan 17 - Jan 18
Quality Inn Cairo I-57

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (284 reviews)
"The hotel was very clean, beds were comfortable, and staff was friendly and helpful."
United States
aileen
The price is ₩128,494
₩146,451 total
includes taxes & fees
Jan 14 - Jan 15
Comfort Inn & Suites Sikeston I-55

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.2 out of 10, Wonderful, (48 reviews)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is ₩146,809
₩166,225 total
includes taxes & fees
Jan 16 - Jan 17
Fairfield Inn & Suites by Marriott Sikeston

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (618 reviews)
"Staff was great! Room was nice. "
United States
Lana
The price is ₩90,265
₩100,164 total
includes taxes & fees
Jan 11 - Jan 12
Super 8 by Wyndham Charleston/Sikeston East MO

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (445 reviews)
"Stay was excellent "
United States
Kourtney
The price is ₩135,180
₩153,059 total
includes taxes & fees
Jan 25 - Jan 26
Holiday Inn Express & Suites Sikeston Southwest by IHG

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,002 reviews)
"A great stay in every aspect. "
United States
Gertrude
The price is ₩91,428
₩104,203 total
includes taxes & fees
Jan 12 - Jan 13
Days Inn and Suites by Wyndham Sikeston

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (42 reviews)
"Very clean room, friendly staff! I would highly recommend this place! "
United States
Lydia
The price is ₩129,366
₩153,626 total
includes taxes & fees
Jan 11 - Jan 12
MainStay Suites Union City, TN

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (168 reviews)
"Staff was great. Room was ready and clean. "
United States
Robert
The price is ₩157,754
₩187,332 total
includes taxes & fees
Jan 25 - Jan 26
Hampton Inn Union City

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.0 out of 10, Good, (464 reviews)
"I had a decent stay near Reelfoot Lake — definitely about a 2-star hotel. I appreciated that the room had tile floors instead of carpet, though they weren’t very clean or well-kept. The door barely locked, which was a bit concerning, and there were dogs barking throughout the night, making it hard to rest. That said, I was thankful to find a place at the last minute, and it served its purpose for a quick overnight stay."
United States
Allison
The price is ₩75,367
₩86,484 total
includes taxes & fees
Jan 29 - Jan 30
Reelfoot Lake Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

More cheap stays in East Prairie

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Hampton Inn Sikeston and Best Western Plus Sikeston. See all available top hotels, or vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
Where can I learn more about changing or cancelling my trip to East Prairie?
To access more information about rescheduling or cancelling your trip to East Prairie, click here.
What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?
Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.
What's it like to stay in East Prairie?
Visitors are sure to enjoy all that East Prairie has to offer. There are 32 hotels and other accommodations in the surrounding area. Find out more about East Prairie.
What should I do while I'm visiting East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Sikeston Depot Museum and New Madrid Historical Museum in the area. Check out what more to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.