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Dec 19 - Dec 20
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Dec 20 - Dec 21
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Dec 19 - Dec 21
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Our top choices for Sikeston hotels

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"Great place and staff, very accommodating!"
United States
Megan
The price is ₩132,850
₩149,857 total
includes taxes & fees
Dec 24 - Dec 25
Drury Plaza Hotel Cape Girardeau Conference Center
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
"Clean room, great location and friendly staff"
United States
Mark
The price is ₩132,850
₩152,735 total
includes taxes & fees
Dec 23 - Dec 24
Drury Inn & Suites Sikeston, MO
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1003)
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is ₩102,882
₩117,259 total
includes taxes & fees
Dec 24 - Dec 25
Best Western Plus Sikeston
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1000)
"Great stay"
United States
Heather
The price is ₩103,325
₩116,567 total
includes taxes & fees
Dec 24 - Dec 25
Pear Tree Inn Cape Girardeau West
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ₩140,247
₩158,218 total
includes taxes & fees
Dec 25 - Dec 26
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (719)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is ₩81,919
₩93,368 total
includes taxes & fees
Dec 21 - Dec 22
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (672)
"Great place "
United States
GUY
The price is ₩124,229
₩134,445 total
includes taxes & fees
Dec 20 - Dec 21
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is ₩171,248
₩194,048 total
includes taxes & fees
Dec 29 - Dec 30
Courtyard by Marriott Cape Girardeau Downtown
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (474)
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is ₩142,166
₩160,383 total
includes taxes & fees
Dec 22 - Dec 23
The Riverview
Business center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"Very friendly staff and great breakfast"
United States
Ray
The price is ₩132,850
₩149,857 total
includes taxes & fees
Dec 24 - Dec 25
Drury Inn & Suites Cape Girardeau
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
"Everything was clean, staff was friendly "
United States
Matthew
The price is ₩110,706
₩127,270 total
includes taxes & fees
Dec 24 - Dec 25
Pear Tree Inn Sikeston
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1002)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ₩122,516
₩129,528 total
includes taxes & fees
Dec 21 - Dec 22
Drury Inn & Suites Jackson MO
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (140)
"Nice hotel, clean and comfortable "
United States
Laura
The price is ₩129,913
₩146,560 total
includes taxes & fees
Dec 28 - Dec 29
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is ₩103,325
₩116,567 total
includes taxes & fees
Dec 24 - Dec 25
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is ₩137,294
₩155,451 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Breakfast, lunch, dinner served; American cuisine
Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (386)
"Very nice"
United States
Dennis
The price is ₩109,614
₩123,092 total
includes taxes & fees
Dec 21 - Dec 22
Travelodge by Wyndham Dexter
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (446)
"Friendly staff clean rooms "
United States
Christopher
The price is ₩144,055
₩163,106 total
includes taxes & fees
Dec 28 - Dec 29
Hampton Inn Sikeston
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (882)
"Room was clean and spacious."
United States
George
The price is ₩113,674
₩136,360 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Candlewood Suites Cape Girardeau by IHG
Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.2 out of 10, Good, (685)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is ₩85,034
₩95,931 total
includes taxes & fees
Dec 25 - Dec 26
Quality Inn Cape Girardeau North
1 bedroom, desk, laptop workspace, blackout drapes
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1001)
"A great stay in every aspect. "
United States
Gertrude
The price is ₩92,858
₩105,834 total
includes taxes & fees
Dec 22 - Dec 23
Days Inn and Suites by Wyndham Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Sikeston attractions

City of Miner Convention Center

This versatile 16,000-square-foot venue in Miner, Missouri hosts conferences, weddings, and community gatherings. Modern meeting rooms and a commercial kitchen make it ideal for various events.
See properties

Central Park

3.8/5 (36 reviews)
Central Park offers a peaceful retreat with playgrounds and open spaces for Sikeston families. Bring a blanket for a relaxing picnic or watch children enjoy the recreational facilities.
See properties

Sikeston and related destinations

Home to Lambert's Café, the 'Home of Throwed Rolls,' where servers toss fresh bread across the room to hungry diners. Visit the historic Sikeston Depot or catch the annual rodeo where professional cowboys compete in thrilling events each August.

See all hotels in Sikeston
The best restaurant I have EVER been to! Hands down!!!
Photo by Ryan Coleman
Open Photo by Ryan Coleman

Top Sikeston Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Didn’t eat the breakfast but I’m sure it is wonderful. Everything from the Check in process to the condition of the rooms to the comfort of the stay was worth the money "
Corrie 1-night trip
Posted 2 days ago
Drury Plaza Hotel Cape Girardeau Conference Center

Frequently asked questions

Where is the best place to stay in Sikeston?
Pear Tree Inn Sikeston is ranked highly by Expedia customers. This hotel offers free breakfast and an outdoor pool. Other top choices based on reviews include Fairfield Inn & Suites by Marriott Sikeston and Drury Inn & Suites Sikeston, MO. See all available top hotels, or vacation rentals in Sikeston.
If I need to cancel my hotel reservation in Sikeston, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Sikeston.
Where can I learn more about changing or cancelling my trip to Sikeston?
For more details about changing or cancelling your trip to Sikeston, head over to our customer service page.
What's the best budget-friendly hotel in Sikeston?
Based on reviews, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) is a popular hotel for our travelers who want a more economical choice, and features free breakfast and free WiFi. View all budget hotels in Sikeston.
What's the best hotel for a family vacation in Sikeston?
Drury Inn & Suites Sikeston, MO is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Pear Tree Inn Sikeston is another good choice for your stay with the kids. Find more child-friendly accommodations in Sikeston.
What is the top LGBTQ-friendly hotel in Sikeston?
Drury Inn & Suites Sikeston, MO is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Pear Tree Inn Sikeston and Hampton Inn Sikeston are two other good options for your vacation. See all available hotels listed as LGBTQ-friendly in Sikeston.
What's the best pet-friendly accommodation in Sikeston?
Drury Inn & Suites Sikeston, MO is a top hotel for people traveling with their pets, and offers an indoor pool and free WiFi for its human guests. Other good options for you and your pet's trip include Days Inn and Suites by Wyndham Sikeston and Hampton Inn Sikeston. See more pet-friendly hotel accommodations in Sikeston.
Where is the best hotel to stay close to Central Park?
Hampton Inn Sikeston is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located just a short 1 mi (1.6 km) from Central Park. Another good option is Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel, located just 0.9 mi (1.5 km) away.
What about the best place to stay close to Sikeston Depot Museum?
One of the top choices for your stay is Pear Tree Inn Sikeston, located 3.1 mi (5 km) from Sikeston Depot Museum, and this hotel offers free breakfast and an outdoor pool. Hampton Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel are two other good options within a few miles.
What are some accommodations with pools in Sikeston?
Best Western Plus Sikeston is a top hotel with a pool, free full breakfast, and free parking. TownePlace Suites by Marriott Sikeston is one more option that features an onsite pool. View all hotels with pools in Sikeston.
What's the best place to stay near Barkley Regional Airport (PAH)?
Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.
What is staying in Sikeston like?
Families will find kid-friendly activities in Sikeston, and visitors give high marks for the top-notch restaurants and shopping. This welcoming city also attracts tourists with its riverfront and university setting. In Sikeston, there are 15 hotels and other accommodations to choose from. Find out more about Sikeston.
What are the top places to visit in Sikeston?
A couple of favorite places to visit are Central Park and Sikeston Depot Museum. You'll also find River Ridge Winery and Front Street Studio & Art Gallery in the area. Check out what more to see and do in Expedia's Sikeston guide.
What's the seasonal weather like in Sikeston?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.

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