Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Check availability on Southeast Missouri Resorts & Hotels with Spas

Tonight
Apr 1 - Apr 2
Tomorrow
Apr 2 - Apr 3
This weekend
Apr 3 - Apr 5
Next weekend
Apr 10 - Apr 12

Our top choices for Southeast Missouri hotels with a spa

Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"This was probably the cleanest hotel we have ever stayed in. The beds were also very comfortable. Staff was also friendly and helpful."
United States
Amber
The price is ₩159,381
₩179,804 total
includes taxes & fees
Apr 12 - Apr 13
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Southeast Missouri

Pool
Breakfast included

Top Southeast Missouri Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Parking was available for my handicap son ,breakfast was great,very clean room and friendly staff "
Edith 1-night trip
Posted 15 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center