Lodging Image

Find hotels in Southeast Missouri, MO from ₩87,492

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Sep 1 - Sep 2
Tomorrow
Sep 2 - Sep 3
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
Perryville
United States
David
₩132,657
₩151,859 total
includes taxes & fees
Sep 6 - Sep 7
Holiday Inn Express & Suites Perryville by IHG

2. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
₩136,746
₩154,268 total
includes taxes & fees
Sep 6 - Sep 7
Drury Plaza Hotel Cape Girardeau Conference Center

3. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
United States
Scott Andrew
₩129,362
₩148,735 total
includes taxes & fees
Sep 14 - Sep 15
Drury Inn & Suites Sikeston, MO

4. Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi
Potosi
United States
Ross
₩79,622
₩86,967 total
includes taxes & fees
Sep 6 - Sep 7
Super 8 by Wyndham Potosi

5. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
Canada
Raidas
₩98,454
₩111,069 total
includes taxes & fees
Sep 6 - Sep 7
Pear Tree Inn Cape Girardeau West

6. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Lori
₩119,679
₩130,729 total
includes taxes & fees
Sep 11 - Sep 12
Madison Inn Lodge

7. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
₩138,128
₩156,396 total
includes taxes & fees
Sep 13 - Sep 14
Fairfield Inn & Suites by Marriott Sikeston

8. Perryville RV Resort

Perryville RV Resort
Perryville
United States
Von
₩90,809
₩103,953 total
includes taxes & fees
Sep 2 - Sep 3
Perryville RV Resort

9. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
United States
Kristin
₩171,087
₩193,866 total
includes taxes & fees
Sep 13 - Sep 14
Courtyard by Marriott Cape Girardeau Downtown

10. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
Susan
₩149,957
₩163,228 total
includes taxes & fees
Sep 2 - Sep 3
Crown Pointe Lodge, BW Signature Collection

11. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
United States
ELAINE
₩138,128
₩157,209 total
includes taxes & fees
Sep 7 - Sep 8
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

12. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
₩156,316
₩176,346 total
includes taxes & fees
Sep 2 - Sep 3
The Riverview

13. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Jamie
₩114,222
₩120,761 total
includes taxes & fees
Sep 21 - Sep 22
Drury Inn & Suites Jackson MO

14. Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
Perryville
United States
Elizabeth
₩96,484
₩110,450 total
includes taxes & fees
Sep 9 - Sep 10
Super 8 by Wyndham Perryville

15. Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
Mountain View
United States
JOAQUIN
₩135,392
₩146,784 total
includes taxes & fees
Sep 5 - Sep 6
Honeysuckle Inn - Mountain View

16. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United States
ILUNGA
₩80,378
₩87,492 total
includes taxes & fees
Sep 13 - Sep 14
Baymont Inn and Suites by Wyndham Farmington, MO

17. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Arsenia
₩138,333
₩156,283 total
includes taxes & fees
Sep 13 - Sep 14
Fairfield Inn & Suites by Marriott Poplar Bluff

18. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
Sikeston
United States
Kevin
₩119,460
₩136,155 total
includes taxes & fees
Sep 2 - Sep 3
Best Western Plus Sikeston I-55

19. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Shawn
₩126,708
₩137,130 total
includes taxes & fees
Sep 2 - Sep 3
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

20. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
United States
Rebekah
₩144,665
₩163,203 total
includes taxes & fees
Sep 13 - Sep 14
Hampton Inn Cape Girardeau I 55 East
View all properties

Vacation Rentals in Southeast Missouri

Cabin

Sam A Baker State Park

Sam A Baker State Park
Patterson
"Pet friendly, great staff. "
Sam A Baker State Park
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
"I really enjoyed my time at the stay !"
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Cabin

Lake Wappapello

Lake Wappapello
Williamsville
"Pet friendly. Family-friendly "
Lake Wappapello
Cottage

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Ironton
"Stroller, pack n play and high chair. This was amazing "
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Aparthotel

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
Perryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
The Atrium - A Boutique Hotel
Vacation Home

Tiny Houses of French Village

Tiny Houses of French Village
French Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Tiny Houses of French Village
Aparthotel

Urban Lofts

Urban Lofts
Perryville
"Beautiful place and staff was amazing!"
Urban Lofts
Cottage

Walk to Current River: Ozarks Adventure Home!

Walk to Current River: Ozarks Adventure Home!
Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Walk to Current River: Ozarks Adventure Home!
Cottage

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cozy Belgrade Cottage w/ Wood-burning Stove!
Belgrade
Cozy Belgrade Cottage w/ Wood-burning Stove!
See all vacation rentals
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties
A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties
A waterfall, a river, and a red building in a forested area.

Current River State Park

9.2/10 (20 reviews)
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
See properties

Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Century Casino Caruthersville

7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
See properties

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Clearwater Lake.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"Front desk was welcoming and nice. Room was cleaned, beds were comfy. Very spacious. Quiet as well."
Tristan 1-night trip
Posted 1 hour ago
Days Inn and Suites by Wyndham Sikeston
The Riverview

The Riverview

10/10 Excellent
"My stay was wonderful and the food was good"
taryn 1-night trip
Posted 17 hours ago
The Riverview
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

8/10 Good
"Everything was good, the only issue I had. Was served the wrong breakfast . Then charged $18.00 for the difference. But the restaurant was busy. So I paid and never said anything. Including the ham I got that I don’t eat."
Carolyn 1-night trip
Posted 18 hours ago
Holiday Inn Poplar Bluff by IHG
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

8/10 Good
"Had a very nice stay for one night while traveling. Room was clean and comfortable."
Patricia 1-night trip
Posted 1 day ago
Drury Inn & Suites Sikeston, MO
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"Nice customer service. I liked the access to washer and dryer, as well as cookies being served in the evening. I like the indoor pool and the gym. Is closed to many restaurants and showing mall."
Elvira 3-night trip
Posted 2 days ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"The room was clean and the bed was comfortable. It was also quiet making it easy to get some sleep before getting back on the road."
Mark 1-night trip
Posted 2 days ago
Motel 6 Poplar Bluff, MO

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
₩80,378
₩87,492 total
Sep 13 - Sep 14
includes taxes & fees
Baymont Inn and Suites by Wyndham Farmington, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
₩89,509
₩102,018 total
Sep 3 - Sep 4
includes taxes & fees
7.2/10 Good! (1,003 reviews)
Days Inn and Suites by Wyndham Sikeston
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO
₩92,067
₩107,581 total
Sep 21 - Sep 22
includes taxes & fees
Comfort Inn Festus - St Louis South
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
₩108,040
₩120,991 total
Sep 2 - Sep 3
includes taxes & fees
8/10 Very Good! (1,002 reviews)
Motel 6 Poplar Bluff, MO
The Farmstead Hotel

The Farmstead Hotel

778 E 3rd St Caruthersville MO
₩129,922
₩147,754 total
Sep 2 - Sep 3
includes taxes & fees
The Farmstead Hotel
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO
₩138,128
₩157,209 total
Sep 7 - Sep 8
includes taxes & fees
9.4/10 Exceptional! (1,002 reviews)
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hotels in Southeast Missouri with star-rating

Explore a world of travel with Expedia