A nighttime pedestrian bridge with illuminated railings and a rainbow-colored light projection on the floor.

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Nov 6 - Nov 8
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Our top choices for Greater South Side hotels

A spacious hotel lobby with a central bar, seating area, and a ceiling fan.

1. Hampton Inn Des Moines-Airport

Hampton Inn Des Moines-Airport
2.5 star property
Greater South Side
8.8 out of 10, Excellent, (1,002 reviews)
"Good place to stay"
United States
Tom
The price is ₩136,102
₩152,434 total
includes taxes & fees
Nov 27 - Nov 28
Hampton Inn Des Moines-Airport
A hotel room with a large bed, a nightstand, a wall-mounted TV, and a window with curtains.

2. Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport
2.0 star property
Greater South Side
8.6 out of 10, Excellent, (1,835 reviews)
"Great place to stay"
United States
Abdifatah
The price is ₩86,923
₩97,354 total
includes taxes & fees
Nov 24 - Nov 25
Days Inn & Suites by Wyndham Des Moines Airport
Breakfast area

3. Quality Inn & Suites Des Moines Airport

Quality Inn & Suites Des Moines Airport
2.5 star property
Greater South Side
7.6 out of 10, Good, (1,003 reviews)
"Our room was clean, quiet, and staff was awesome. The price was very reasonable."
United States
Jennifer
The price is ₩85,779
₩96,073 total
includes taxes & fees
Nov 24 - Nov 25
Quality Inn & Suites Des Moines Airport
A reception desk with a sign reading "AmericInn" and a clock on the wall.

4. AmericInn by Wyndham Des Moines Airport

AmericInn by Wyndham Des Moines Airport
3.0 star property
Greater South Side
8.0 out of 10, Very good, (1,006 reviews)
"Clean, well stocked, plenty of parking, and good breakfast included."
United States
Daisy
The price is ₩85,041
₩95,246 total
includes taxes & fees
Nov 16 - Nov 17
AmericInn by Wyndham Des Moines Airport
A multi-level indoor atrium with a central pool, surrounded by seating areas and potted plants.

5. Holiday Inn Des Moines-Airport/Conf Center by IHG

Holiday Inn Des Moines-Airport/Conf Center by IHG
3.0 star property
Greater South Side
8.4 out of 10, Very good, (738 reviews)
"Nice location, clean facility."
United States
sandeep
The price is ₩154,738
₩173,307 total
includes taxes & fees
Nov 21 - Nov 22
Holiday Inn Des Moines-Airport/Conf Center by IHG
A luxurious living room with a stone fireplace, a large mirror, and two blue armchairs.

6. Des Lux Hotel

Des Lux Hotel
3.5 star property
Court District, 3.9 km from Greater South Side
9.6 out of 10, Exceptional, (1,115 reviews)
"Great place to stay!"
United States
Bryan
The price is ₩216,768
₩242,791 total
includes taxes & fees
Nov 10 - Nov 11
Des Lux Hotel
A spacious lobby with high ceilings, large windows, and a chandelier.

7. Hotel Fort Des Moines, Curio Collection by Hilton

Hotel Fort Des Moines, Curio Collection by Hilton
4.5 star property
Western Gateway, 3.7 km from Greater South Side
9.6 out of 10, Exceptional, (1,407 reviews)
"Love the Bar and Restaurant also the Rooms were perfect with great staff in all locations."
United States
Christopher
The price is ₩166,267
₩186,219 total
includes taxes & fees
Nov 15 - Nov 16
Hotel Fort Des Moines, Curio Collection by Hilton
An indoor swimming pool with clear water, a no diving sign, and a pool ladder.

8. Holiday Inn Express & Suites Des Moines Downtown by IHG

Holiday Inn Express & Suites Des Moines Downtown by IHG
2.5 star property
Downtown Des Moines, 3.2 km from Greater South Side
9.2 out of 10, Wonderful, (1,003 reviews)
"Very nice hotel. Staff was very friendly. And the room was very clean and comfy."
United States
CaSandra
The price is ₩138,592
₩155,222 total
includes taxes & fees
Dec 1 - Dec 2
Holiday Inn Express & Suites Des Moines Downtown by IHG
A spacious lobby with a bar area, seating arrangements, and a high ceiling with recessed lighting.

9. Des Moines Marriott Downtown

Des Moines Marriott Downtown
3.5 star property
Downtown Des Moines, 4.1 km from Greater South Side
8.8 out of 10, Excellent, (1,001 reviews)
"Hotel was clean and enjoyed our stay."
United States
Nancy
The price is ₩180,087
₩201,698 total
includes taxes & fees
Nov 9 - Nov 10
Des Moines Marriott Downtown
A modern building with a sign that reads 'Staybridge Suites.' It features a mix of glass and brick facades, large windows, and a flat roof.

10. Staybridge Suites Des Moines Downtown by IHG

Staybridge Suites Des Moines Downtown by IHG
3.0 star property
Historic East Village, 4.5 km from Greater South Side
9.2 out of 10, Wonderful, (1,003 reviews)
"Clean great stay!!!"
United States
Emily
The price is ₩152,074
₩170,323 total
includes taxes & fees
Nov 15 - Nov 16
Staybridge Suites Des Moines Downtown by IHG
An outdoor seating area with a circular fire pit, wicker furniture, and string lights.

11. Residence Inn Des Moines Downtown

Residence Inn Des Moines Downtown
3.0 star property
Court District, 3.9 km from Greater South Side
8.8 out of 10, Excellent, (694 reviews)
"Good location"
United States
Jill
The price is ₩140,906
₩157,815 total
includes taxes & fees
Nov 30 - Dec 1
Residence Inn Des Moines Downtown
A modern bar with wooden shelves and a long counter.

12. Surety Hotel, Autograph Collection

Surety Hotel, Autograph Collection
4.0 star property
Court District, 3.8 km from Greater South Side
9.4 out of 10, Exceptional, (1,000 reviews)
"Conveniently located well appointed property. Staff were very helpful."
Australia
Brett
The price is ₩204,524
₩229,067 total
includes taxes & fees
Nov 26 - Nov 27
Surety Hotel, Autograph Collection
A modern lobby with a central bar area, seating arrangements, and a distinctive ceiling design.

13. Hilton Des Moines Downtown

Hilton Des Moines Downtown
3.5 star property
Downtown Des Moines, 4.5 km from Greater South Side
9.0 out of 10, Wonderful, (1,002 reviews)
"Best location for any event at the Casey’s center. Walking distance to great food. Easy walk to events. Hotel is great"
United States
Brent
The price is ₩177,206
₩204,434 total
includes taxes & fees
Nov 15 - Nov 16
Hilton Des Moines Downtown
A spacious hotel lobby with a blue sofa, a grey armchair, and a flat-screen TV mounted on a textured wall.

14. Comfort Inn & Suites Event Center

Comfort Inn & Suites Event Center
2.5 star property
Downtown Des Moines, 4.9 km from Greater South Side
8.8 out of 10, Excellent, (1,008 reviews)
"One of the nicest comfort inns I’ve stayed at it was very quiet for being in a busy spot of town"
United States
Ana
The price is ₩124,665
₩139,624 total
includes taxes & fees
Nov 9 - Nov 10
Comfort Inn & Suites Event Center
An outdoor patio area with tables and chairs, a fire pit, and string lights.

15. Fairfield Inn & Suites by Marriott Des Moines Downtown

Fairfield Inn & Suites by Marriott Des Moines Downtown
4.0 star property
Downtown Des Moines, 4.8 km from Greater South Side
9.0 out of 10, Wonderful, (541 reviews)
"Great location to all of downtown"
United States
CINDY
The price is ₩157,303
₩176,179 total
includes taxes & fees
Nov 9 - Nov 10
Fairfield Inn & Suites by Marriott Des Moines Downtown
An outdoor dining area with a table set for two, a city skyline in the background, and a Ferris wheel illuminated against the evening sky.

16. Embassy Suites by Hilton Des Moines Downtown

Embassy Suites by Hilton Des Moines Downtown
3.5 star property
Historic East Village, 4.4 km from Greater South Side
8.4 out of 10, Very good, (1,000 reviews)
"First time at this hotel in Des Moines downtown. Entire experience was wonderful. The morning breakfast was the best we have ever had from a hotel stay. Within walking distance of everything we wanted to do downtown."
United States
Patty
The price is ₩173,924
₩194,794 total
includes taxes & fees
Nov 15 - Nov 16
Embassy Suites by Hilton Des Moines Downtown
An outdoor seating area with yellow chairs and a colorful sofa, a fire pit, and a wooden ceiling with hanging lights.

17. Home2 Suites by Hilton Des Moines at Drake University

Home2 Suites by Hilton Des Moines at Drake University
3.0 star property
Drake, 5.6 km from Greater South Side
9.4 out of 10, Exceptional, (1,010 reviews)
"Super comfy bed breakfast wasnt bad lots of options"
United States
Cassandra
The price is ₩123,593
₩138,424 total
includes taxes & fees
Nov 24 - Nov 25
Home2 Suites by Hilton Des Moines at Drake University
A modern dining area with a large island table, multiple chairs, and a chandelier.

18. Hampton Inn & Suites Des Moines Downtown

Hampton Inn & Suites Des Moines Downtown
2.5 star property
Court District, 3.9 km from Greater South Side
8.6 out of 10, Excellent, (1,003 reviews)
"Friendly staff and decent breakfast."
United States
Kristy
The price is ₩141,108
₩158,040 total
includes taxes & fees
Nov 29 - Nov 30
Hampton Inn & Suites Des Moines Downtown
A multi-story hotel with a classic brick facade, large windows, and a prominent Liberty Building sign.

19. Hyatt Place Des Moines/Downtown

Hyatt Place Des Moines/Downtown
3.0 star property
Downtown Des Moines, 4.1 km from Greater South Side
8.2 out of 10, Very good, (1,004 reviews)
"The breakfast was very good and so were the bed and linens. Very nice fitness center and pool very friendly staff!"
United States
dinah
The price is ₩147,540
₩165,245 total
includes taxes & fees
Nov 17 - Nov 18
Hyatt Place Des Moines/Downtown
A modern hotel lobby with a round coffee table, sofas, and a TV mounted on the wall.

20. Homewood Suites by Hilton Des Moines Airport

Homewood Suites by Hilton Des Moines Airport
3.0 star property
3.7 km from Greater South Side
9.4 out of 10, Exceptional, (706 reviews)
"Perfect stay!!"
United States
Larry
The price is ₩140,126
₩156,942 total
includes taxes & fees
Nov 27 - Nov 28
Homewood Suites by Hilton Des Moines Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Greater South Side

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A spacious hotel lobby with a central bar, seating area, and a ceiling fan.
Hampton Inn Des Moines-Airport
2.5 star property
8.8
Excellent
1,002 reviews
View
A hotel room with a large bed, a nightstand, a wall-mounted TV, and a window with curtains.
Days Inn & Suites by Wyndham Des Moines Airport
2.0 star property
8.6
Excellent
1,835 reviews
View
A multi-level indoor atrium with a central pool, surrounded by seating areas and potted plants.
Holiday Inn Des Moines-Airport/Conf Center by IHG
3.0 star property
8.4
Very good
738 reviews
View
A reception desk with a sign reading "AmericInn" and a clock on the wall.
AmericInn by Wyndham Des Moines Airport
3.0 star property
8.0
Very good
1,006 reviews
View
Breakfast area
Quality Inn & Suites Des Moines Airport
2.5 star property
7.6
Good
1,003 reviews
View

Where to stay in Greater South Side

Find the best Greater South Side areas and neighborhoods for the activities you enjoy most.
The entrance to the Greater Des Moines Botanical Garden with a large dome structure in the background.

Downtown Des Moines

Downtown Des Moines boasts corporate campuses, fine dining, and unique retail destinations. Explore the Pappajohn Sculpture Park, and enjoy easy access to DART transit and skywalk connections.

A sign reading "Historic East Village" with a clear blue sky and clouds in the background.

Historic East Village

Directly east of Downtown Des Moines, this nationally recognized historic district boasts the Iowa State Capitol complex, State of Iowa Historical Museum, and Des Moines Botanical Gardens. Explore eateries, boutique shops, and loft-style housing in its charming structures.

A city skyline at night with illuminated buildings and a prominent tower.
Photo by Ryan Brohm
Open Photo by Ryan Brohm

Court District

Court District is known for its ample dining options, and you can make a stop by Science Center of Iowa and Principal Park while in the area.

The exterior and interior of Mars Cafe, featuring a brick facade, large windows, and a red interior with hanging lights and artwork.
Photo by Eric Mondres
Open Photo by Eric Mondres

Drake

If you're spending some time in Drake, Knapp Center and Des Moines Community Playhouse are top sights worth seeing.

A city skyline at dusk with illuminated buildings, a bridge, and a river.

Beaverdale

If you're looking for some top things to see and do in Beaverdale and surrounding area, you can visit Merle Hay Mall and Knapp Center.

Top Greater South Side Hotel Reviews

Hampton Inn Des Moines-Airport

Hampton Inn Des Moines-Airport

10/10 Excellent
"You will love staying here!"
Sheryl 1-night trip
Posted 2 hours ago
Hampton Inn Des Moines-Airport

Frequently asked questions

What's it like in Greater South Side?
Travelers are sure to enjoy a stay in Des Moines's Greater South Side neighborhood. Consider a visit to Gray's Lake Park as part of your Greater South Side travel plans.
What's a favorite place to stay in Greater South Side?
Based on our traveler data, Days Inn & Suites by Wyndham Des Moines Airport is one of the top choices for your stay in Greater South Side. This hotel offers free breakfast and an indoor pool. Other good options for your stay in the neighborhood include Hampton Inn Des Moines-Airport and AmericInn by Wyndham Des Moines Airport.
How many hotels will I be able to find in Greater South Side?
With 17 Expedia hotels and other accommodations in Greater South Side to choose from, this is a good starting point for exploring the greater Des Moines area.
If I need to cancel my hotel reservation in Greater South Side, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable if cancelled before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get top deals in Greater South Side.
Where can I learn more about changing or cancelling my trip to Greater South Side?
For more information about changing or cancelling your trip to Greater South Side, head over to our customer service page.
What is there to do around this Des Moines neighborhood?
Gray's Lake Park is an attraction you might want to check out while you're in Greater South Side. While you're out sightseeing, Air Lanes Bowling Center and Lauridsen Amphitheater are a couple of additional sights to visit in Des Moines.