A nighttime pedestrian bridge with illuminated railings and a rainbow-colored light projection on the floor.

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Oct 23 - Oct 25
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Our top choices for Greater South Side hotels

A spacious hotel lobby with a central bar, seating area, and a ceiling fan.

1. Hampton Inn Des Moines-Airport

Hampton Inn Des Moines-Airport
2.5 star property
Greater South Side
8.8 out of 10, Excellent, (1,002 reviews)
"Great place to stay and is real close to the airport"
United States
Jayson
The price is ₩127,663
₩142,984 total
includes taxes & fees
Oct 24 - Oct 25
Hampton Inn Des Moines-Airport
A hotel room with a large bed, a nightstand, a wall-mounted TV, and a window with curtains.

2. Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport
2.0 star property
Greater South Side
8.6 out of 10, Excellent, (1,820 reviews)
"The pool was warm, the staff was great, clean room, hot water, breakfast was decent. Great price, great stay."
United States
Amanda
The price is ₩88,461
₩99,076 total
includes taxes & fees
Nov 8 - Nov 9
Days Inn & Suites by Wyndham Des Moines Airport
Breakfast area

3. Quality Inn & Suites Des Moines Airport

Quality Inn & Suites Des Moines Airport
2.5 star property
Greater South Side
7.6 out of 10, Good, (1,002 reviews)
"Reasonable price close to airport"
United States
Barbara
The price is ₩87,380
₩97,866 total
includes taxes & fees
Nov 16 - Nov 17
Quality Inn & Suites Des Moines Airport
A reception desk with a sign reading "AmericInn" and a clock on the wall.

4. AmericInn by Wyndham Des Moines Airport

AmericInn by Wyndham Des Moines Airport
3.0 star property
Greater South Side
8.0 out of 10, Very good, (1,000 reviews)
"Clean, well stocked, plenty of parking, and good breakfast included."
United States
Daisy
The price is ₩85,058
₩95,265 total
includes taxes & fees
Nov 8 - Nov 9
AmericInn by Wyndham Des Moines Airport
A spacious indoor area with multiple levels, featuring a central open space with tables and chairs, surrounded by balconies and a large, colorful ceiling structure.

5. Holiday Inn Des Moines-Airport/Conf Center by IHG

Holiday Inn Des Moines-Airport/Conf Center by IHG
3.0 star property
Greater South Side
8.4 out of 10, Very good, (733 reviews)
"Nice location, clean facility."
United States
sandeep
The price is ₩152,105
₩170,357 total
includes taxes & fees
Oct 26 - Oct 27
Holiday Inn Des Moines-Airport/Conf Center by IHG
A luxurious living room with a stone fireplace, a large mirror, and two blue armchairs.

6. Des Lux Hotel

Des Lux Hotel
3.5 star property
Court District, 3.9 km from Greater South Side
9.8 out of 10, Exceptional, (1,107 reviews)
"Friendly staff and rooms are cozy."
United States
Bobbi
The price is ₩202,939
₩227,302 total
includes taxes & fees
Oct 18 - Oct 19
Des Lux Hotel
A spacious lobby with high ceilings, large windows, and a chandelier.

7. Hotel Fort Des Moines, Curio Collection by Hilton

Hotel Fort Des Moines, Curio Collection by Hilton
4.5 star property
Western Gateway, 3.7 km from Greater South Side
9.6 out of 10, Exceptional, (1,378 reviews)
"Beautiful hotel! Enjoyable stay!"
United States
Karen
The price is ₩166,301
₩186,257 total
includes taxes & fees
Nov 15 - Nov 16
Hotel Fort Des Moines, Curio Collection by Hilton
A spacious lobby with a bar area, seating arrangements, and a high ceiling with recessed lighting.

8. Des Moines Marriott Downtown

Des Moines Marriott Downtown
3.5 star property
Downtown Des Moines, 4.1 km from Greater South Side
8.8 out of 10, Excellent, (1,002 reviews)
"Hotel was clean and enjoyed our stay."
United States
Nancy
The price is ₩180,124
₩201,738 total
includes taxes & fees
Nov 8 - Nov 9
Des Moines Marriott Downtown
A Holiday Inn Express building with a brick facade, multiple windows, and a covered entrance.

9. Holiday Inn Express & Suites Des Moines Downtown by IHG

Holiday Inn Express & Suites Des Moines Downtown by IHG
2.5 star property
Downtown Des Moines, 3.2 km from Greater South Side
9.2 out of 10, Wonderful, (1,003 reviews)
"The staff is super friendly and supportive. Some amenities (pool) were closed due to construction. Property was clean and breakfast is always great."
United States
Joe
The price is ₩132,091
₩147,942 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express & Suites Des Moines Downtown by IHG
A modern kitchen with dark cabinets, stainless steel appliances, and a tiled backsplash.

10. Staybridge Suites Des Moines Downtown by IHG

Staybridge Suites Des Moines Downtown by IHG
3.0 star property
Historic East Village, 4.5 km from Greater South Side
9.2 out of 10, Wonderful, (1,001 reviews)
"Clean great stay!!!"
United States
Emily
The price is ₩152,874
₩171,219 total
includes taxes & fees
Oct 25 - Oct 26
Staybridge Suites Des Moines Downtown by IHG
An outdoor seating area with a circular fire pit, wicker furniture, and string lights.

11. Residence Inn Des Moines Downtown

Residence Inn Des Moines Downtown
3.0 star property
Court District, 3.9 km from Greater South Side
8.8 out of 10, Excellent, (689 reviews)
"This place was great! Perfect location for walking to all the things! The staff were amazing, the lady at the front desk was so welcoming and kind. Breakfast was very good! Room was clean, spacious and bed was comfy!"
United States
Nicole
The price is ₩151,464
₩169,640 total
includes taxes & fees
Nov 15 - Nov 16
Residence Inn Des Moines Downtown
A modern bar with wooden shelves and a long counter.

12. Surety Hotel, Autograph Collection

Surety Hotel, Autograph Collection
4.0 star property
Court District, 3.8 km from Greater South Side
9.4 out of 10, Exceptional, (1,000 reviews)
"Conveniently located well appointed property. Staff were very helpful."
Australia
Brett
The price is ₩225,488
₩252,546 total
includes taxes & fees
Nov 15 - Nov 16
Surety Hotel, Autograph Collection
An outdoor patio area with tables and chairs, a fire pit, and string lights.

13. Fairfield Inn & Suites by Marriott Des Moines Downtown

Fairfield Inn & Suites by Marriott Des Moines Downtown
4.0 star property
Downtown Des Moines, 4.8 km from Greater South Side
9.0 out of 10, Wonderful, (535 reviews)
"Great location to all of downtown"
United States
CINDY
The price is ₩127,981
₩143,339 total
includes taxes & fees
Nov 8 - Nov 9
Fairfield Inn & Suites by Marriott Des Moines Downtown
A table set with white flowers, candles, and silverware, suggesting a formal dining setting.

14. Hilton Des Moines Downtown

Hilton Des Moines Downtown
3.5 star property
Downtown Des Moines, 4.5 km from Greater South Side
9.0 out of 10, Wonderful, (1,000 reviews)
"Great stay! The bartenders were amazing!"
United States
Sweta
The price is ₩184,900
₩213,306 total
includes taxes & fees
Nov 10 - Nov 11
Hilton Des Moines Downtown
A spacious hotel lobby with a blue sofa, a grey armchair, and a flat-screen TV mounted on a textured wall.

15. Comfort Inn & Suites Event Center

Comfort Inn & Suites Event Center
2.5 star property
Downtown Des Moines, 4.9 km from Greater South Side
8.8 out of 10, Excellent, (1,001 reviews)
"Another great stay as usual!"
United States
Thomas
The price is ₩123,618
₩138,453 total
includes taxes & fees
Nov 9 - Nov 10
Comfort Inn & Suites Event Center
A multi-level hotel atrium with balconies, artwork, and indoor plants.

16. Embassy Suites Hotel Des Moines Downtown

Embassy Suites Hotel Des Moines Downtown
3.5 star property
Historic East Village, 4.4 km from Greater South Side
8.4 out of 10, Very good, (1,001 reviews)
"We love the rooms with the 2 rooms! We love the breakfast because a chef makes made to order omelets!! We love this beautiful hotel! It’s where we stay in Des Moines!"
United States
Candy
The price is ₩173,960
₩194,835 total
includes taxes & fees
Nov 5 - Nov 6
Embassy Suites Hotel Des Moines Downtown
A modern dining area with a large island table, multiple chairs, and a chandelier.

17. Hampton Inn & Suites Des Moines Downtown

Hampton Inn & Suites Des Moines Downtown
2.5 star property
Court District, 3.9 km from Greater South Side
8.6 out of 10, Excellent, (1,003 reviews)
"I needed an early check in and conjoined rooms. Staff was more than willing to accommodate my requests!"
United States
April
The price is ₩141,137
₩158,074 total
includes taxes & fees
Nov 8 - Nov 9
Hampton Inn & Suites Des Moines Downtown
An outdoor seating area with yellow chairs and a colorful sofa, a fire pit, and a wooden ceiling with hanging lights.

18. Home2 Suites by Hilton Des Moines at Drake University

Home2 Suites by Hilton Des Moines at Drake University
3.0 star property
Drake, 5.6 km from Greater South Side
9.4 out of 10, Exceptional, (1,006 reviews)
"Super comfy bed breakfast wasnt bad lots of options"
United States
Cassandra
The price is ₩123,618
₩138,452 total
includes taxes & fees
Nov 16 - Nov 17
Home2 Suites by Hilton Des Moines at Drake University
A multi-story hotel with a classic brick facade, large windows, and a prominent Liberty Building sign.

19. Hyatt Place Des Moines/Downtown

Hyatt Place Des Moines/Downtown
3.0 star property
Downtown Des Moines, 4.1 km from Greater South Side
8.2 out of 10, Very good, (1,001 reviews)
"Very nice hotel will stay there again"
United States
Felicia
The price is ₩146,768
₩164,381 total
includes taxes & fees
Nov 6 - Nov 7
Hyatt Place Des Moines/Downtown
A modern hotel lobby with a round coffee table, sofas, and a TV mounted on the wall.

20. Homewood Suites by Hilton Des Moines Airport

Homewood Suites by Hilton Des Moines Airport
3.0 star property
3.7 km from Greater South Side
9.4 out of 10, Exceptional, (693 reviews)
"Clean hotel, breakfast was good, room was very comfortable. Nice hotel, enjoyed our stay"
United States
nola
The price is ₩142,271
₩159,344 total
includes taxes & fees
Nov 16 - Nov 17
Homewood Suites by Hilton Des Moines Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Greater South Side

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A spacious hotel lobby with a central bar, seating area, and a ceiling fan.
Hampton Inn Des Moines-Airport
2.5 star property
8.8
Excellent
1,002 reviews
View
A hotel room with a large bed, a nightstand, a wall-mounted TV, and a window with curtains.
Days Inn & Suites by Wyndham Des Moines Airport
2.0 star property
8.6
Excellent
1,820 reviews
View
A spacious indoor area with multiple levels, featuring a central open space with tables and chairs, surrounded by balconies and a large, colorful ceiling structure.
Holiday Inn Des Moines-Airport/Conf Center by IHG
3.0 star property
8.4
Very good
733 reviews
View
A reception desk with a sign reading "AmericInn" and a clock on the wall.
AmericInn by Wyndham Des Moines Airport
3.0 star property
8.0
Very good
1,000 reviews
View
Breakfast area
Quality Inn & Suites Des Moines Airport
2.5 star property
7.6
Good
1,002 reviews
View

Where to stay in Greater South Side

Find the best Greater South Side areas and neighborhoods for the activities you enjoy most.
The entrance to the Greater Des Moines Botanical Garden with a large dome structure in the background.

Downtown Des Moines

Downtown Des Moines boasts corporate campuses, fine dining, and unique retail destinations. Explore the Pappajohn Sculpture Park, and enjoy easy access to DART transit and skywalk connections.

A sign reading "Historic East Village" with a clear blue sky and clouds in the background.

Historic East Village

Directly east of Downtown Des Moines, this nationally recognized historic district boasts the Iowa State Capitol complex, State of Iowa Historical Museum, and Des Moines Botanical Gardens. Explore eateries, boutique shops, and loft-style housing in its charming structures.

A city skyline at night with illuminated buildings and a prominent tower.
Photo by Ryan Brohm
Open Photo by Ryan Brohm

Court District

Court District is known for its ample dining options, and you can make a stop by Science Center of Iowa and Principal Park while in the area.

The exterior and interior of Mars Cafe, featuring a brick facade, large windows, and a red interior with hanging lights and artwork.
Photo by Eric Mondres
Open Photo by Eric Mondres

Drake

If you're spending some time in Drake, Knapp Center and Des Moines Community Playhouse are top sights worth seeing.

A city skyline at sunset with illuminated buildings and domed structures.

Woodland Heights

While Woodland Heights might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Hoyt Sherman Place and John and Mary Pappajohn Sculpture Park.

Top Greater South Side Hotel Reviews

La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA

La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA

8/10 Good
"Hotel is Clean, New, nice constant fan (block noise), good water pressure in shower. Good breakfast, too."
Rory 1-night trip
Posted 4 hours ago
La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA

Frequently asked questions

What's it like in Greater South Side?
Travelers are sure to enjoy a stay in Des Moines's Greater South Side neighborhood. Consider a visit to Gray's Lake Park as part of your Greater South Side travel plans.
What's a favorite place to stay in Greater South Side?
Based on our traveler data, Days Inn & Suites by Wyndham Des Moines Airport is one of the top choices for your stay in Greater South Side. This hotel offers free breakfast and an indoor pool. Other good options for your stay in the neighborhood include Hampton Inn Des Moines-Airport and AmericInn by Wyndham Des Moines Airport.
How many hotels will I be able to find in Greater South Side?
With 17 Expedia hotels and other accommodations in Greater South Side to choose from, this is a good starting point for exploring the greater Des Moines area.
If I need to cancel my hotel reservation in Greater South Side, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable if cancelled before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get top deals in Greater South Side.
Where can I learn more about changing or cancelling my trip to Greater South Side?
For more information about changing or cancelling your trip to Greater South Side, head over to our customer service page.
What is there to do around this Des Moines neighborhood?
Gray's Lake Park is an attraction you might want to check out while you're in Greater South Side. While you're out sightseeing, Air Lanes Bowling Center and Lauridsen Amphitheater are a couple of additional sights to visit in Des Moines.